Association of polymorphism in the serotonin transporter gene promote with the susceptibility to alcohol dependence in Yunnan Han Population

2011 ◽  
Vol 33 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Xue-Jing WANG ◽  
Shu-Rong ZHONG ◽  
Jian-Jun BAO ◽  
Shao-Jing DOU ◽  
Wen-Yu WU ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Han Population

scholarly journals Lack of Association Between Serotonin Transporter Gene (SLC6A4) Promoter Methylation and Amygdala Response During Negative Emotion Processing in Individuals With Alcohol Dependence

2019 ◽  
Vol 54 (3) ◽  
pp. 209-215 ◽  
Author(s):  
Christine Muench ◽  
Audrey Luo ◽  
Katrin Charlet ◽  
Jisoo Lee ◽  
Daniel B Rosoff ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Serotonin Transporter ◽  
Promoter Methylation ◽  
Promoter Region ◽  
Serotonin Transporter Gene ◽  
Matching Task ◽  
Transporter Gene ◽  
Healthy Individuals ◽  
Brain Functions ◽  
Amygdala Activation

Abstract Aims Differences in DNA methylation of the serotonin transporter gene (SLC6A4) have been shown to alter SLC6A4 expression and predict brain functions in healthy individuals. This study investigated the association between SLC6A4 promoter methylation and threat-related amygdala activation in individuals with alcohol dependence (AD). Methods Methylation of the SLC6A4 promoter region was assessed using peripheral blood DNA from 45 individuals with AD and 45 healthy controls (HCs). All participants completed an emotional face matching task in a 3-T magnetic resonance imaging (MRI) scanner. Results Results did not reveal any association between SLC6A4 promoter methylation variation and threat-related amygdala activation in HCs or individuals with AD. Furthermore, methylation in the promoter region of SLC6A4 did not significantly differ between the groups. Conclusions Our results do not replicate a previous finding that increased methylation in the promoter region of SLC6A4 is associated with threat-related amygdala activation in healthy individuals and further show that there is no such association in individuals with AD. Given that the number of imaging epigenetics studies on SLC6A4 is very limited to date, these inconsistent results indicate that future research is needed to clarify its association with amygdala reactivity in both healthy and clinical populations.

scholarly journals The serotonin transporter gene and risk for alcohol dependence: A meta-analytic review

2010 ◽  
Vol 108 (1-2) ◽  
pp. 1-6 ◽  
Author(s):  
R. Kathryn McHugh ◽  
Stefan G. Hofmann ◽  
Anu Asnaani ◽  
Alice T. Sawyer ◽  
Michael W. Otto
Keyword(s):  
Alcohol Dependence ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Analytic Review

Serotonin transporter gene polymorphism and personality traits in primary alcohol dependence

2004 ◽  
Vol 5 (1) ◽  
pp. 45-48 ◽  
Author(s):  
Gerhard A Wiesbeck ◽  
Heinz-gerd Weijers ◽  
Norbert Wodarz ◽  
Heike K Keller ◽  
Tanja M Michel ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Alcohol Dependence ◽  
Personality Traits ◽  
Serotonin Transporter ◽  
Primary Alcohol ◽  
Serotonin Transporter Gene ◽  
Transporter Gene

Serotonin transporter gene linked polymorphism (5-HTTLPR) determines progredience of alcohol dependence in Belarusian young males

2019 ◽  
Vol 64 (1) ◽  
pp. 169-173 ◽  
Author(s):  
Andrei Kapitau ◽  
Inessa Goloenko ◽  
Victor Obyedkov ◽  
Kirill Pavlov ◽  
Sławomir Dariusz Szajda ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Young Males

A Family-Based Analysis of Whether the Functional Promoter Alleles of the Serotonin Transporter Gene HTT Affect the Risk for Alcohol Dependence

1998 ◽  
Vol 22 (5) ◽  
pp. 1080-1085 ◽  
Author(s):  
Howard J. Edenberg ◽  
Jennifer Reynolds ◽  
Daniel L Koller ◽  
Henri Begleiter ◽  
Kathleen K. Bucholz ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Family Based

Support for Allelic Association of a Polymorphic Site in the Promoter Region of the Serotonin Transporter Gene With Risk for Alcohol Dependence

2000 ◽  
Vol 157 (12) ◽  
pp. 2045-2047 ◽  
Author(s):  
Dirk Lichtermann ◽  
Dubravka Hranilović ◽  
Màtyàs Trixler ◽  
Petra Franke ◽  
Branimir Jernej ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Serotonin Transporter ◽  
Promoter Region ◽  
Polymorphic Site ◽  
Serotonin Transporter Gene ◽  
Allelic Association ◽  
Transporter Gene
Sign in / Sign up

Export Citation Format

Share Document