scholarly journals A preformulation strategy for the selection of controlled-release components to simulate a subcutaneous implant

Author(s):  
Kaining Zhi ◽  
◽  
David B. Lebo ◽  
1993 ◽  
Vol 86 (2) ◽  
pp. 208-214 ◽  
Author(s):  
RENÉE J. GOLDBERG ARNOLD ◽  
DIANA J. KANIECKI

Weed Science ◽  
1978 ◽  
Vol 26 (6) ◽  
pp. 679-686 ◽  
Author(s):  
M. M. Schreiber ◽  
B. S. Shasha ◽  
M. A. Ross ◽  
P. L. Orwick ◽  
D. W. Edgecomb

Four starch-encapsulated formulations of EPTC(S-ethyl dipropylthiocarbamate) and of butylate(S-ethyl diisobutylthiocarbamate) were prepared and evaluated by comparison with their respective emulsifiable concentrate formulations for their slow-release capabilities and efficacies. Chemical and biological evaluation indicated that difference in controlled-release could be achieved by the selection of the starch xanthate and oxidant used in the formualtion process. EPTC and butylate released slower when formulated as starch-encapsulated granules than when formulated as emulsifiable concentrates under soil conditions that favored rapid release. The initial release was adequate for weed control and slow enough for desired residual activity. Repeated seeding and harvesting the treated soils and bioassays of treated soils generally produced release rate anticipated from short term dry and wet chemical tests.


2013 ◽  
Vol 441 (1-2) ◽  
pp. 468-475 ◽  
Author(s):  
Marco Bragagni ◽  
Cristina Beneitez ◽  
Cristina Martín ◽  
Dolores Hernán Pérez de la Ossa ◽  
Paola Angela Mura ◽  
...  

SLEEP ◽  
2019 ◽  
Vol 42 (Supplement_1) ◽  
pp. A242-A243 ◽  
Author(s):  
David Monteith ◽  
Julien Grassot ◽  
Charlotte Castellan ◽  
Thomas Roth

2021 ◽  
Vol 14 (5) ◽  
pp. 442
Author(s):  
Vesela Kostova ◽  
Patrice Désos ◽  
Jérôme-Benoît Starck ◽  
Andras Kotschy

Combining the selective targeting of tumor cells through antigen-directed recognition and potent cell-killing by cytotoxic payloads, antibody-drug conjugates (ADCs) have emerged in recent years as an efficient therapeutic approach for the treatment of various cancers. Besides a number of approved drugs already on the market, there is a formidable follow-up of ADC candidates in clinical development. While selection of the appropriate antibody (A) and drug payload (D) is dictated by the pharmacology of the targeted disease, one has a broader choice of the conjugating linker (C). In the present paper, we review the chemistry of ADCs with a particular emphasis on the medicinal chemistry perspective, focusing on the chemical methods that enable the efficient assembly of the ADC from its three components and the controlled release of the drug payload.


2000 ◽  
Vol 25 (4) ◽  
pp. 402-404 ◽  
Author(s):  
Shigeru TASHIMA ◽  
Shinji SHIMADA ◽  
Motomu NIIKAWA ◽  
Kohei MATSUMOTO ◽  
Reiji TAKEDA ◽  
...  

2015 ◽  
Vol 494 (1) ◽  
pp. 288-295 ◽  
Author(s):  
Marta Casas ◽  
Ángela Aguilar-de-Leyva ◽  
Isidoro Caraballo

2019 ◽  
Vol 42 ◽  
Author(s):  
Gian Domenico Iannetti ◽  
Giorgio Vallortigara

Abstract Some of the foundations of Heyes’ radical reasoning seem to be based on a fractional selection of available evidence. Using an ethological perspective, we argue against Heyes’ rapid dismissal of innate cognitive instincts. Heyes’ use of fMRI studies of literacy to claim that culture assembles pieces of mental technology seems an example of incorrect reverse inferences and overlap theories pervasive in cognitive neuroscience.


1975 ◽  
Vol 26 ◽  
pp. 395-407
Author(s):  
S. Henriksen

The first question to be answered, in seeking coordinate systems for geodynamics, is: what is geodynamics? The answer is, of course, that geodynamics is that part of geophysics which is concerned with movements of the Earth, as opposed to geostatics which is the physics of the stationary Earth. But as far as we know, there is no stationary Earth – epur sic monere. So geodynamics is actually coextensive with geophysics, and coordinate systems suitable for the one should be suitable for the other. At the present time, there are not many coordinate systems, if any, that can be identified with a static Earth. Certainly the only coordinate of aeronomic (atmospheric) interest is the height, and this is usually either as geodynamic height or as pressure. In oceanology, the most important coordinate is depth, and this, like heights in the atmosphere, is expressed as metric depth from mean sea level, as geodynamic depth, or as pressure. Only for the earth do we find “static” systems in use, ana even here there is real question as to whether the systems are dynamic or static. So it would seem that our answer to the question, of what kind, of coordinate systems are we seeking, must be that we are looking for the same systems as are used in geophysics, and these systems are dynamic in nature already – that is, their definition involvestime.


1978 ◽  
Vol 48 ◽  
pp. 515-521
Author(s):  
W. Nicholson

SummaryA routine has been developed for the processing of the 5820 plates of the survey. The plates are measured on the automatic measuring machine, GALAXY, and the measures are subsequently processed by computer, to edit and then refer them to the SAO catalogue. A start has been made on measuring the plates, but the final selection of stars to be made is still a matter for discussion.


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