College students were classified as either skilled or less skilled readers on the basis of reading comprehension scores and were then asked to judge whether high-frequency words, low-frequency words, orthographically legal nonwords, and orthographically illegal nonwords were words or nonwords. Skilled readers were significantly faster than less skilled readers on this task for all stimulus categories, but the largest differences between groups were found for low-frequency words and legal nonwords. Differences between the groups were larger for orthographically illegal nonwords than for high-frequency words. It was concluded that less skilled college readers do not use orthographic structure as an aid in lexical decisions as well as skilled readers and that their ability to decode even high-frequency words is not as automatic as that of the skilled readers.