scholarly journals A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative

2010 ◽  
Vol 6 ◽  
pp. 1056-1060 ◽  
Author(s):  
Nimalini Devi Moirangthem ◽  
Warjeet Singh Laitonjam
Keyword(s):  
Ethyl Cyanoacetate ◽  
Pyrimidine Derivative ◽  
Synthetic Approach ◽  
Facile Synthesis ◽  
Benzenoid System ◽  
Active Methylene Compounds ◽  
Pyrimidine Moiety ◽  
Derivatives Of ◽  
Active Methylene

A new and facile synthesis of 2-thioxoquinazolin-4-ones by introducing a benzenoid system in the pyrimidine moiety by reacting ethoxymethylene derivatives of 1,3-diarylthiobarbituric acids (DTBA) with active methylene compounds, such as malononitrile and ethyl cyanoacetate, in presence of ZnCl2 has been developed.

Synthesis and chemical reactions of some conjugated heteroenoid compounds

1967 ◽  
Vol 45 (9) ◽  
pp. 1001-1006 ◽  
Author(s):  
R. F. Silver ◽  
K. Ann Kerr ◽  
Peggy D. Frandsen ◽  
Sheila J. Kelley ◽  
H. L. Holmes
Keyword(s):  
Chemical Reactions ◽  
Room Temperature ◽  
Cyano Group ◽  
Ethyl Cyanoacetate ◽  
Geometric Configuration ◽  
Cinnamic Acids ◽  
Active Methylene Compounds ◽  
Derivatives Of ◽  
Active Methylene

A series of 326 3-benzal-2,4-pentanediones, 2-benzal-1,3-indanediones, ethyl benzalaceto-acetates, diethyl benzalmalonates, ethyl benzalcyanoacetates, benzalmalononitriles, benzalcyanoacetamides, benzalcyanoacetanilides, benzalmalonamides, β-nitrostyrenes, β-nitropropenylbenzenes, β-nitrobutenylbenzenes, and derivatives of a number of cinnamic acids have been synthesized and their geometric configuration discussed. Aniline, p-toluidine, and n-butanethiol have been added to some of these compounds. The aniline adducts have also been prepared from benzylideneaniline and the active methylene compounds. The aniline adducts of those containing a cyano group are not stable and lose aniline at room temperature. The structure of the compound prepared from benzylideneaniline and ethyl cyanoacetate and melting at 140 °C has been established.

Polarographic half-wave potentials and ultraviolet absorption spectra of some conjugated heteroenoid compounds

1969 ◽  
Vol 47 (21) ◽  
pp. 4076-4083 ◽  
Author(s):  
H. L. Holmes ◽  
D. J. Currie
Keyword(s):  
Absorption Spectra ◽  
Functional Groups ◽  
Ultraviolet Absorption ◽  
Half Wave ◽  
Active Methylene Compounds ◽  
Derivatives Of ◽  
Active Methylene ◽  
Hammett Relationship

The half-wave potentials of phenyl substituted derivatives for each series of conjugated heteroenoid compounds studied follow a Hammett relationship. The effect of change in the functional groups and of increase in length of the conjugated system upon half-wave potentials and ultraviolet absorption maxima is briefly discussed. Terephthalylidene derivatives of active methylene compounds function like the cinnamylidene derivatives.

Amino Acid Derivatives in Organic Synthesis, Part 4 [1]: Facile Synthesis of Heterocycles Containing a Glycine Residue

2000 ◽  
Vol 55 (1) ◽  
pp. 104-108 ◽  
Author(s):  
Laila M. Chabaka ◽  
Yehia A. Allam ◽  
Galal A. M. Nawwar
Keyword(s):  
Amino Acid ◽  
Organic Synthesis ◽  
Acid Group ◽  
The Other ◽  
Amino Acid Derivatives ◽  
Carboxylic Acid Group ◽  
Facile Synthesis ◽  
Peptide Linkage ◽  
Active Methylene Compounds ◽  
Active Methylene

Pyridines, thiazolopyridines and pyrazolopyrans containing glycinate residue were prepared by reacting N-cyanoacryloglycinate ylidenes with active methylene compounds via a Michael addition - intracyclization synthetic pathway.Simple routes for the synthesis of heterocycles with an amino acid residue were previously reported [1-3] as the incorportation of these residues improves the pharmacokinetics and toxicity of active compounds [4,5]. However, trials to deesterify these residues for coupling purposes were unsuccessful. So, we tried herein new approaches for synthesizing heterocyles carrying one or two glycine moieties with free carboxylic acid group to facilitate further peptide linkage [6] on one hand and on the other one could be able to form metal chelates, a property having a significant output on the toxicological behaviour [7]

A Facile Synthesis of Fluorine-Containing 1,7-Phenanthrolines by the Cyclization of N-Propargyl-6,8-bis(trifluoroacetyl)quinolin-5-amine with Various Active Methylene Compounds

Heterocycles ◽  
2010 ◽  
Vol 82 (1) ◽  
pp. 803 ◽  
Author(s):  
Etsuji Okada ◽  
Dai Shibata ◽  
Ayaka Sakai ◽  
Mizuki Hatakenaka ◽  
Shohei Saikawa ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
Active Methylene Compounds ◽  
Active Methylene

Acylaminoacetyl derivatives of active methylene compounds.3.C-Acylation Reactionsviathe Hippuric Acid Azlactone

1994 ◽  
Vol 31 (5) ◽  
pp. 1145-1150 ◽  
Author(s):  
Stylianos Hamilakis ◽  
Demetrios Kontonassios ◽  
Constantine Sandris
Keyword(s):  
Hippuric Acid ◽  
Active Methylene Compounds ◽  
Derivatives Of ◽  
Active Methylene

scholarly journals Catalyst-free four-component domino synthetic approach toward versatile multicyclic spirooxindole pyran scaffolds

RSC Advances ◽  
2019 ◽  
Vol 9 (29) ◽  
pp. 16525-16533 ◽  
Author(s):  
Aref Mohammadi ◽  
Mohammad Bayat ◽  
Shima Nasri
Keyword(s):  
Synthetic Approach ◽  
Catalyst Free ◽  
Active Methylene Compounds ◽  
Active Methylene

Synthesis of spirooxindole pyrans by a sequential four-component reaction of nitroketene dithioacetals, alkylamine/benzylamine, isatin, and active methylene compounds.

Reactions of ferrocenyl chalcones with hydrazines and active methylene compounds

2016 ◽  
Vol 22 (2) ◽  
pp. 69-77 ◽  
Author(s):  
Marwa El-Hussieny ◽  
Hisham Abdallah A. Yosef ◽  
Mohamed R.H. Mahran ◽  
Nabila M. Ibrahim
Keyword(s):  
Hydrazine Hydrate ◽  
Reaction Mechanisms ◽  
Ethyl Acetoacetate ◽  
New Products ◽  
Ethyl Cyanoacetate ◽  
Spectroscopic Methods ◽  
Phenyl Hydrazine ◽  
Active Methylene Compounds ◽  
Ferrocenyl Chalcones ◽  
Active Methylene

AbstractClaisen-Schmidt condensation of ferrocenecarboxaldehyde (2b) with 2-acetylfuran (4) yielded (E)-3-ferrocenyl-1-(2-furyl)prop-2-en-1-one (E-5) together with 1,5-di(2-furyl)-3-ferrocenylpentane-1,5-dione (6). Reactions of the ferrocenyl chalcones 3a,b and 5 with hydrazine hydrate, phenyl hydrazine, ethyl acetoacetate, ethyl cyanoacetate and malononitrile, were also studied. Possible reaction mechanisms were discussed and structures of the new products were unambiguously characterized by common analytical and spectroscopic methods.

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