Synthesis of fluorinated δ-lactams via cycloisomerization of gem-difluoropropargyl amides
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gem-Difluoro-1,7-enyne amides are suitable building blocks for the synthesis of difluorodihydropyridinones via a ring-closing metathesis reaction, and of 4,4-difluoro-3-oxoisoquinolines through a ring-closing metathesis–enyne metathesis tandem reaction. These products, in turn, undergo a Diels–Alder reaction to yield heterotricyclic systems in moderate to good yields.
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2020 ◽
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2017 ◽
Vol 139
(23)
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pp. 7713-7716
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2010 ◽
Vol 75
(12)
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pp. 4319-4322
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