Th1/Th2 cytokine profiles differentiating tuberculous from malignant pleural effusions: A systematic review and meta-analysis

Review question / Objective: To clarify which one has a different predominance of Th1 and Th2 immune responses in malignant and tuberculous pleural effusions. We did a meta-analysis of the results published previously to assess the levels of Th1/Th2 cytokines in two types of pleural effusion and evaluated its ability to distinguish TPE from MPE. Condition being studied: Malignant and tuberculous pleural effusions are the two most common types of exudative pleural effusions, both of which can be seen with the typical accumulation of lymphocytes. Immune responses mediated by either the Th1 or Th2 subset dominate, depending on different types of pleural effusion. Thus, we performed a meta-analysis of all available studies to quantitatively evaluate the levels of Th1/Th2 cytokine profiles in TPE and MPE, as well as to assess the potential diagnostic value of these cytokines in discriminating TPE from MPE.

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Novel aggregate structure adjuvants modulate lymphocyte proliferation and Th1 and Th2 cytokine profiles in ovalbumin immunized mice

Vaccine ◽

10.1016/s0264-410x(99)00213-3 ◽

1999 ◽

Vol 18 (1-2) ◽

pp. 140-152 ◽

Cited By ~ 36

Author(s):

Palasingam Rajananthanan ◽

George S Attard ◽

Nadeem A Sheikh ◽

W.John W Morrow

Keyword(s):

Lymphocyte Proliferation ◽

Aggregate Structure ◽

Cytokine Profiles ◽

Th2 Cytokine ◽

Th1 And Th2

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Th1 and Th2 Cytokine Profiles in Successful Pregnancy and Unexplained Recurrent Abortions

Reproductive Immunology ◽

10.1007/978-94-011-4197-0_14 ◽

1999 ◽

pp. 149-158 ◽

Cited By ~ 3

Author(s):

R. Raghupathy ◽

M. Makhseed ◽

F. Azizieh ◽

M. M. K. Al-Azemi ◽

N. A. Hassan ◽

...

Keyword(s):

Successful Pregnancy ◽

Cytokine Profiles ◽

Th2 Cytokine ◽

Recurrent Abortions ◽

Th1 And Th2

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Diagnostic value of pleural effusion for the detection of EGFR in NSCLC: a meta-analysis

10.1183/13993003.congress-2019.pa3063 ◽

2019 ◽

Author(s):

Lan Yang ◽

Panwen Tian ◽

Weimin Li

Keyword(s):

Pleural Effusion ◽

Meta Analysis ◽

Diagnostic Value

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Diagnostic value of interleukins for tuberculous pleural effusion: a systematic review and meta-analysis

BMC Pulmonary Medicine ◽

10.1186/s12890-017-0530-3 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 6

Author(s):

Ni Zeng ◽

Chun Wan ◽

Jiangyu Qin ◽

Yanqiu Wu ◽

Ting Yang ◽

...

Keyword(s):

Systematic Review ◽

Pleural Effusion ◽

Meta Analysis ◽

Diagnostic Value ◽

Tuberculous Pleural Effusion

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Th1 and Th2 cytokine profiles in recurrent aborters may merely reflect the progesterone status

Human Reproduction ◽

10.1093/humrep/17.6.1669 ◽

2002 ◽

Vol 17 (6) ◽

pp. 1669-1670 ◽

Cited By ~ 3

Author(s):

Jerome H. Check

Keyword(s):

Cytokine Profiles ◽

Th2 Cytokine ◽

Th1 And Th2

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Assessment of the diagnostic value of CEA, CA125, and CRP and their cut-off point for discrimination of exudative pleural effusions

Bionatura ◽

10.21931/rb/2021.06.03.10 ◽

2021 ◽

Vol 3 (3) ◽

pp. 1944-1947

Author(s):

Hanie Raji ◽

Seyed Hamid Borsi ◽

Mehrdad Dargahi MalAmir ◽

Ahmad Reza Asadollah Salmanpour

Keyword(s):

Pleural Effusion ◽

Tumor Marker ◽

Pleural Fluid ◽

Tumor Markers ◽

Low Cost ◽

High Specificity ◽

Diagnostic Value ◽

Pleural Effusions ◽

Cross Sectional ◽

The Mean

Pleural effusion is divided into exudative and transudative effusion, and the distinction between exudate and transudate requires multiple investigations of biochemical parameters and their comparison in pleural fluid and serum. This study aimed to assess the diagnostic value of CEA, CA125, and CRP and their cut-off point for discrimination of exudative pleural effusions. This epidemiological and cross-sectional study was performed on 50 patients aged between 18 to 90 years with the diagnosis of exudative pleural effusion referred to Imam Khomeini Hospital in Ahvaz in 2018 and 2019. Demographic and clinical information of patients were collected. The pleural effusion was diagnosed based on physical examination and chest radiography. Pleural effusion was confirmed by thoracentesis. A pleural fluid sample was taken from all patients, and the levels of CEA, CA125, and CRP markers were measured in the pleural fluid. Differentiation of transudate and exudate pleural effusions was performed using Light criteria. The mean CEA and CA125 level of pleural fluid were significantly higher, and the mean CRP level of pleural fluid was significantly lower in patients with malignant diagnoses (P <0.05). Cut-off value with highest sensitivity and specificity in differentiating types of exudative pleural effusions was obtained for CEA tumor marker (greater than 49.8), CA125 tumor marker (greater than 814.02), and CRP marker (less than 7.56). Also, in differentiating types of exudative pleural effusions, CEA tumor marker had sensitivity (89.03%) and specificity (78.42%); CA125 tumor marker had sensitivity (53.18%) and specificity (62.44%), and CRP marker had sensitivity (82.16%), and specificity (89.05%) were. Although the tumor markers had high specificity in the present study, the low sensitivity of some of these tumor markers reduced their diagnostic value. On the other hand, given the numerous advantages of tumor markers, such as low cost and non-invasive, combining them with another can increase the diagnostic value and accuracy.

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Determination of tissue polypeptide-specific antigen in pleural fluid and serum from patients with pleural effusion

The International Journal of Biological Markers ◽

10.1177/172460089501000306 ◽

1995 ◽

Vol 10 (3) ◽

pp. 161-165 ◽

Cited By ~ 1

Author(s):

V. Villena ◽

J. Echave-Sustaeta ◽

A. Lopez-Encuentra ◽

P. Martin-Escribano ◽

J. Estenoz-Alfaro ◽

...

Keyword(s):

Pleural Effusion ◽

Pleural Fluid ◽

Sensitivity And Specificity ◽

Specific Antigen ◽

Diagnostic Value ◽

Pleural Effusions ◽

Malignant Pleural Effusions ◽

Cytologic Analysis

As a tool for differentiating malignant and benign pleural effusions, we evaluated the diagnostic value of the assay of tissue polypeptide-specific antigen (TPS) in pleural fluid and serum, and of the pleural fluid TPS/serum TPS ratio in patients with pleural effusion. We studied prospectively 147 consecutive patients who had pleural effusions: 43 malignant pleural effusions and 104 benign pleural effusions. TPS levels were measured by RIA. The sensitivity and specificity of these measurements were: TPS in pleural fluid (cutoff 20,000 U/L): 0.21 and 0.98; TPS in serum (cutoff 300 U/L): 0.31 and 0.96; pleural fluid TPSI serum TPS ratio (cutoff 1200): 0.07 and 0.99. All these values enhanced the sensitivity of cytologic analysis of pleural fluid. However, we conclude that TPS assay in pleural fluid and serum, and the pleural fluid TPSI serum TPS ratio have limited diagnostic value in patients with pleural effusion.

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