Evaluation of corneal transparency in eyes treated with brimonidine

2021 ◽  
Vol 16 (3) ◽  
pp. 131
Author(s):  
Orhan Altunel ◽  
Saadet Gültekin Irgat ◽  
Fatih Özcura
Keyword(s):  
Corneal Transparency

The cellular basis of corneal transparency: evidence for ‘corneal crystallins’

1999 ◽  
Vol 112 (5) ◽  
pp. 613-622 ◽  
Author(s):  
J.V. Jester ◽  
T. Moller-Pedersen ◽  
J. Huang ◽  
C.M. Sax ◽  
W.T. Kays ◽  
...  
Keyword(s):  
Cellular Level ◽  
Soluble Proteins ◽  
Water Soluble ◽  
Corneal Tissue ◽  
Corneal Epithelial Cells ◽  
Corneal Epithelial ◽  
Corneal Transparency ◽  
Scattering Measurements ◽  
Class 1

In vivo corneal light scattering measurements using a novel confocal microscope demonstrated greatly increased backscatter from corneal stromal fibrocytes (keratocytes) in opaque compared to transparent corneal tissue in both humans and rabbits. Additionally, two water-soluble proteins, transketolase (TKT) and aldehyde dehydrogenase class 1 (ALDH1), isolated from rabbit keratocytes showed unexpectedly abundant expression (approximately 30% of the soluble protein) in transparent corneas and markedly reduced levels in opaque scleral fibroblasts or keratocytes from hazy, freeze injured regions of the cornea. Together these data suggest that the relatively high expressions of TKT and ALDH1 contribute to corneal transparency in the rabbit at the cellular level, reminiscent of enzyme-crystallins in the lens. We also note that ALDH1 accumulates in the rabbit corneal epithelial cells, rather than ALDH3 as seen in other mammals, consistent with the taxon-specificity observed among lens enzyme-crystallins. Our results suggest that corneal cells, like lens cells, may preferentially express water-soluble proteins, often enzymes, for controlling their optical properties.

Eye Development and the Appearance and Maintenance of Corneal Transparency

1992 ◽  
Vol 95 (1/2) ◽  
pp. 34 ◽  
Author(s):  
Gary W. Conrad ◽  
James L. Funderburgh
Keyword(s):  
Eye Development ◽  
Corneal Transparency

Effects of Ablation Diameter on Long-term Refractive Stability and Corneal Transparency after Photorefractive Keratectomy

Ophthalmology ◽  
2006 ◽  
Vol 113 (10) ◽  
pp. 1798-1806 ◽  
Author(s):  
Madhavan S. Rajan ◽  
David O’Brart ◽  
Philip Jaycock ◽  
John Marshall
Keyword(s):  
Photorefractive Keratectomy ◽  
Corneal Transparency

Objective and quantitative analysis of corneal transparency with clinical spectral-domain optical coherence tomography

2019 ◽  
Author(s):  
Romain Bocheux ◽  
Bathilde Rivière ◽  
Pascal Pernot ◽  
Cristina Georgeon ◽  
Vincent Borderie ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Quantitative Analysis ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Corneal Transparency

Corneal transparency: anatomical basis and evaluation methods

2017 ◽  
Vol 133 (5) ◽  
pp. 84
Author(s):  
S. E. Avetisov ◽  
M. N. Narbut
Keyword(s):  
Evaluation Methods ◽  
Corneal Transparency ◽  
Anatomical Basis

scholarly journals Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Cestmir Cejka ◽  
Jan Kossl ◽  
Barbora Hermankova ◽  
Vladimir Holan ◽  
Jitka Cejkova
Keyword(s):  
Oxidative Stress ◽  
Proinflammatory Cytokines ◽  
Molecular Hydrogen ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Rabbit Cornea ◽  
Corneal Transparency ◽  
Corneal Hydration ◽  
Alkali Injury ◽  
Phosphate Buffered Saline

The aim of this study was to examine the effect of molecular hydrogen (H2) on the healing of alkali-injured cornea. The effects of the solution of H2in phosphate buffered saline (PBS) or PBS alone topically applied on the alkali-injured rabbit cornea with 0.25 M NaOH were investigated using immunohistochemical and biochemical methods. Central corneal thickness taken as an index of corneal hydration was measured with an ultrasonic pachymeter. Results show that irrigation of the damaged eyes with H2solution immediately after the injury and then within next five days renewed corneal transparency lost after the injury and reduced corneal hydration increased after the injury to physiological levels within ten days after the injury. In contrast, in injured corneas treated with PBS, the transparency of damaged corneas remained lost and corneal hydration elevated. Later results—on day 20 after the injury—showed that in alkali-injured corneas treated with H2solution the expression of proinflammatory cytokines, peroxynitrite, detected by nitrotyrosine residues (NT), and malondialdehyde (MDA) expressions were very low or absent compared to PBS treated injured corneas, where NT and MDA expressions were present. In conclusion, H2solution favorably influenced corneal healing after alkali injury via suppression of oxidative stress.

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