scholarly journals Chronic hepatitis C virus infection and atherosclerosis risk

2016 ◽  
Vol 11 (2) ◽  
pp. 127-131
Author(s):  
Eliza ACATRINEI ◽  
◽  
Petre CALISTRU ◽  
◽  
◽  
...  

Chronic hepatitis C virus infection (HCV) and cardiovascular disease (CVD) are both diseases with significant global impact through increased prevalence in the general population, and the increased mortality rates. Accumulating evidence suggests the role of HCV infection as an independent risk factor for cardiovascular disease and especially for atherosclerosis, being described multiple pathogenic mechanisms that correlates the two affections. Based on these observations we consider essential the screening for atherosclerosis and cardiovascular risk assessment in patients chronically infected HCV.

Hepatology ◽  
2000 ◽  
Vol 31 (4) ◽  
pp. 997-1004 ◽  
Author(s):  
Lucia De Franceschi ◽  
Giovanna Fattovich ◽  
Franco Turrini ◽  
Kodjo Ayi ◽  
Carlo Brugnara ◽  
...  

2011 ◽  
Vol 140 (5) ◽  
pp. S-934
Author(s):  
Fasiha Kanwal ◽  
Tuyen Hoang ◽  
Jennifer R. Kramer ◽  
Timothy Chrusciel ◽  
Steven M. Asch ◽  
...  

2004 ◽  
Vol 78 (4) ◽  
pp. 2152-2157 ◽  
Author(s):  
Christel Gremion ◽  
Benno Grabscheid ◽  
Benno Wölk ◽  
Darius Moradpour ◽  
Jürg Reichen ◽  
...  

ABSTRACT The role of Fas-mediated lysis of hepatocytes in hepatitis C virus (HCV)-induced injury is frequently discussed. We therefore analyzed the effect of the number of HCV antigen-expressing cells, the mode of antigen presentation, and the number of cytotoxic T lymphocytes in a coculture system mimicking cellular components of the liver. Here, we show that endogenously processed HCV proteins are capable of inducing bystander killing. We further demonstrate that 0.8 to 1.5% of cells presenting HCV antigens suffice to induce lysis of 10 to 29% of bystander cells, suggesting that the mechanism may be operative at low fractions of infected versus uninfected hepatocytes in vivo. Our data underscore the role of the Fas pathway in HCV-related liver injury and support the exploration of Fas-based treatment strategies for patients with chronic hepatitis C virus infection.


2008 ◽  
Vol 14 (47) ◽  
pp. 7149 ◽  
Author(s):  
Juan R Larrubia ◽  
Selma Benito-Martínez ◽  
Miryam Calvino ◽  
Eduardo Sanz-de-Villalobos ◽  
Trinidad Parra-Cid

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