scholarly journals Detection, Isolation and Characterization of Principal Synthetic Route Indicative Impurities in Verapamil Hydrochloride

2011 ◽  
Vol 79 (3) ◽  
pp. 555-568 ◽  
Author(s):  
Viswanathan SRINIVASAN
Keyword(s):  
Synthetic Route ◽  
Verapamil Hydrochloride ◽  
Isolation And Characterization

scholarly journals Detection, Isolation and Characterization of Principal Synthetic Route Indicative Impurity in Lansoprazole

2010 ◽  
Vol 7 (3) ◽  
pp. 844-848 ◽  
Author(s):  
K. S. V Srinivas ◽  
K. Mukkanti ◽  
R. Buchi Reddy ◽  
P. Srinivasulu
Keyword(s):  
Thermal Degradation ◽  
Limit Of Detection ◽  
Catalytic Degradation ◽  
Stress Conditions ◽  
Preparative Hplc ◽  
Synthetic Route ◽  
Limit Of Quantification ◽  
Isolation And Characterization

An unknown impurity in lansoprazole (2-[[[3-methyl-4-(2, 2, 2-trifluoroethoxy)-2-pyridyl] methyl] sulfinyl] benzimidazole) was detected by HPLC and was identified as des-(trifluoroethoxy) lansoprazole, an principal synthetic route indicative impurity of lansoprazole. Lansoprazole was subjected to different ICH prescribed stress conditions like hydrolysis, oxidation, photolysis and thermal degradation conditions to enrich the impurity. The impurity was enriched by using acid catalytic degradation, isolated by using preparative HPLC and characterized (FTIR, MS and NMR). Limit of Detection (LOD) and Limit of Quantification (LOQ) are found to be 0.014% and 0.035% respectively.

scholarly journals Highly Selective Synthesis of 6-Glyoxylamidoquinoline Derivatives via Palladium-Catalyzed Aminocarbonylation

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 4
Author(s):  
Sami Chniti ◽  
László Kollár ◽  
Attila Bényei ◽  
Attila Takács
Keyword(s):  
Selective Synthesis ◽  
Single Crystal Xrd ◽  
Atmospheric Conditions ◽  
Synthetic Route ◽  
Reaction Conditions ◽  
Isolation And Characterization ◽  
Xrd Study ◽  
Optimization Study ◽  
Palladium Catalyzed

The aminocarbonylation of 6-iodoquinoline has been investigated in the presence of large series of amine nucleophiles, providing an efficient synthetic route for producing various quinoline-6-carboxamide and quinoline-6-glyoxylamide derivatives. It was shown, after detailed optimization study, that the formation of amides and ketoamides is strongly influenced by the reaction conditions. Performing the reactions at 40 bar of carbon monoxide pressure in the presence of Pd(OAc)2/2 PPh3, the corresponding 2-ketocarboxamides were formed as major products (up to 63%). When the monodentate triphenylphosphine was replaced by the bidentate XantPhos, the quinoline-6-carboxamide derivatives were synthesized almost exclusively under atmospheric conditions (up to 98%). The isolation and characterization of the new carbonylated products of various structures were also accomplished. Furthermore, the structure of three new mono- and double-carbonylated compounds were unambiguously established by using a single-crystal XRD study.

scholarly journals Detection, isolation and characterization of principle synthetic route indicative impurity in telmisartan

2016 ◽  
Vol 9 ◽  
pp. S1516-S1522 ◽  
Author(s):  
V. Srinivasan ◽  
H. Sivaramakrishnan ◽  
B. Karthikeyan
Keyword(s):  
Synthetic Route ◽  
Isolation And Characterization

The isolation and characterization of 18 equine microsatellite loci, TKY272–TKY289

2000 ◽  
Vol 31 (2) ◽  
pp. 149-149 ◽  
Author(s):  
T Tozaki ◽  
H Kakoi ◽  
S Mashima ◽  
K Hirota ◽  
T Hasegawa ◽  
...  
Keyword(s):  
Microsatellite Loci ◽  
Isolation And Characterization

Isolation and characterization of new phenanthrenes from Juncus inflexus and their chemotaxonomic significance

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
B Tóth ◽  
N Kúsz ◽  
A Csorba ◽  
T Kurtán ◽  
J Hohmann ◽  
...  
Keyword(s):  
Isolation And Characterization

Isolation and characterization of acetylcholinesterase inhibitors from Piper longum Linn.

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
Z Khatami ◽  
P Sarkheil ◽  
HR Adhami
Keyword(s):  
Acetylcholinesterase Inhibitors ◽  
Piper Longum ◽  
Isolation And Characterization
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