Dihydropyrimidine Dehydrogenase Deficiency, a Pharmacogenetic Syndrome Associated with Potentially Life-Threatening Toxicity Following 5-Fluorouracil Administration

2004 ◽  
Vol 4 (3) ◽  
pp. 181-189 ◽  
Author(s):  
Hany Ezzeldin ◽  
Robert Diasio
Keyword(s):  
Dehydrogenase Deficiency ◽  
Dihydropyrimidine Dehydrogenase ◽  
Life Threatening ◽  
Dihydropyrimidine Dehydrogenase Deficiency

Successful use of uridine triacetate (Vistogard) three weeks after capecitabine in a patient with homozygous dihydropyrimidine dehydrogenase mutation: A case report and review of the literature

2017 ◽  
Vol 25 (1) ◽  
pp. 234-238 ◽  
Author(s):  
Mira Zurayk ◽  
Yi-Kong Keung ◽  
David Yu ◽  
Eddie HL Hu
Keyword(s):  
Dehydrogenase Deficiency ◽  
Dihydropyrimidine Dehydrogenase ◽  
Female Breast Cancer ◽  
Chemotherapeutic Agents ◽  
Review Of The Literature ◽  
Female Breast ◽  
Solid Malignancies ◽  
Life Threatening ◽  
Dihydropyrimidine Dehydrogenase Deficiency ◽  
Increased Susceptibility

5-fluorouracil and capecitabine are chemotherapeutic agents commonly used to treat solid malignancies. Increased susceptibility to 5-fluorouracil or capecitabine, caused by impaired clearance, dihydropyrimidine dehydrogenase deficiency, or other genetic mutations in the enzymes that metabolize 5-fluorouracil can lead to severe life-threatening toxicities and are typically manifested by an early onset of symptoms. We report and discuss the management and outcome of capecitabine toxicity with the recently FDA approved antidote, uridine triacetate (Vistogard), in a 57-year-old female breast cancer patient with homozygous dihydropyrimidine dehydrogenase deficiency who received treatment beyond the recommended 96 h window from the last dose of capecitabine.

Dihydropyrimidine Dehydrogenase Deficiency Caused by a Novel Genomic Deletion c.505_513del ofDPYD

2010 ◽  
Vol 29 (4-6) ◽  
pp. 509-514 ◽  
Author(s):  
A. B. P. van Kuilenburg ◽  
J. Meijer ◽  
G. Gökcay ◽  
T. Baykal ◽  
M. E. Rubio-Gozalbo ◽  
...  
Keyword(s):  
Dehydrogenase Deficiency ◽  
Dihydropyrimidine Dehydrogenase ◽  
Genomic Deletion ◽  
Dihydropyrimidine Dehydrogenase Deficiency

Dihydropyrimidine Dehydrogenase Deficiency

2009 ◽  
pp. 534-535
Author(s):  
Dieter Metze ◽  
Tam Nguyen ◽  
Birgit Haack ◽  
Alexander K. C. Leung ◽  
Noriko Miyake ◽  
...  
Keyword(s):  
Dehydrogenase Deficiency ◽  
Dihydropyrimidine Dehydrogenase ◽  
Dihydropyrimidine Dehydrogenase Deficiency
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