scholarly journals Inhibitory effect of Nymphoides indica extract on α-MSH induced melanin synthesis

2017 ◽  
Vol 60 (4) ◽  
pp. 327-332 ◽  
Author(s):  
Dong-Hee Kim ◽  
You-Ah Kim ◽  
Jae-Myo Yu ◽  
Chae-Bin Park ◽  
Byoung-Jun Park ◽  
...  
2015 ◽  
Vol 81 ◽  
pp. 228-234 ◽  
Author(s):  
Hemachandran Hridya ◽  
Anantharaman Amrita ◽  
Mohan Sankari ◽  
C. George Priya Doss ◽  
Mohan Gopalakrishnan ◽  
...  

2019 ◽  
Vol 20 (3) ◽  
pp. 536 ◽  
Author(s):  
Ga-Young Seo ◽  
Yuna Ha ◽  
Ah-Hyun Park ◽  
Oh Kwon ◽  
Youn-Jung Kim

Leathesia difformis (L.) Areschoug (L. difformis) is a species of littoral brown algae of the class Phaeophyceae. Only a few studies on the apoptotic, antiviral, and antioxidant properties of L. difformis have been reported, and its inhibitory effect on melanin synthesis has not been studied. The aim of this study was to investigate the anti-melanogenic effect of L. difformis extract on α-melanocyte-stimulating hormone (α-MSH)-induced B16F10 melanocytes and its mechanism of action. L. difformis was extracted using 80% ethanol (LDE) and then fractioned between ethyl acetate (LDE-EA) and water (LDE-A). Our data demonstrated that LDE-EA significantly inhibited melanin level and cellular tyrosinase activity in α-MSH-stimulated B16 cells. In addition, the expression of genes associated with melanin synthesis, such as microphthalmia-associated transcription factor (Mitf), tyrosinase (Tyr), tyrosinase-related protein-1 (Trp-1), dopachrome tautomerase (Dct), and melanocortin 1 receptor (Mc1r) was down-regulated by LDE-EA treatment. Moreover, LDE-EA decreased p-CREB levels, which suggests that the inhibition of the cAMP/PKA/CREB pathways may be involved in the anti-melanogenic effect of LDE-EA. Thus, this study revealed that LDE-EA is an effective inhibitor of hyperpigmentation through inhibition of CREB pathways and may be considered as a potential therapeutic agent for hyperpigmentation disorders.


2016 ◽  
Vol 33 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Chang Taek Oh ◽  
Tae-Rin Kwon ◽  
Eun Ja Choi ◽  
Soon Re Kim ◽  
Joon Seok ◽  
...  

2007 ◽  
Vol 17 (11) ◽  
pp. 3105-3108 ◽  
Author(s):  
Yutaka Tokiwa ◽  
Masaru Kitagawa ◽  
Takao Raku ◽  
Shusaku Yanagitani ◽  
Kenji Yoshino

2018 ◽  
Vol 45 ◽  
pp. 199-205 ◽  
Author(s):  
Nam-Joo Jeon ◽  
Yon-Suk Kim ◽  
Eun-Kyung Kim ◽  
Xin Dong ◽  
Jae-Woong Lee ◽  
...  

2003 ◽  
Vol 12 (s2) ◽  
pp. 43-50 ◽  
Author(s):  
Akiko Usuki ◽  
Akiko Ohashi ◽  
Hirofumi Sato ◽  
Yasunobu Ochiai ◽  
Masamitsu Ichihashi ◽  
...  

2017 ◽  
Vol 38 (4) ◽  
pp. 62-81
Author(s):  
Jae-Song Choi ◽  
Jung-Hwan Park ◽  
Young-Mee Koh ◽  
Jin-young Kwak ◽  
Taek-Won Ahn

2014 ◽  
Vol 52 (1) ◽  
pp. 1-5
Author(s):  
In-Woo Kim ◽  
Joon Ha Lee ◽  
Yong-Nam Kwon ◽  
Sang-Hee Kim ◽  
Eun-Young Yun ◽  
...  

2013 ◽  
Vol 26 (5) ◽  
pp. 526-532 ◽  
Author(s):  
Youngsic Jeon ◽  
Yujung Jung ◽  
Jong-Kyung Youm ◽  
Yong Kee Kim ◽  
Su-Nam Kim

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