scholarly journals Kai-Xin-San, a traditional Chinese medicine formulation, exerts antidepressive and neuroprotective effects by promoting pCREB upstream pathways

2016 ◽  
Vol 12 (5) ◽  
pp. 3308-3314 ◽  
Author(s):  
Xian-Zhe Dong ◽  
Dong-Xiao Wang ◽  
Bing-Ying Yu ◽  
Ping Liu ◽  
Yuan Hu
1999 ◽  
Vol 27 (01) ◽  
pp. 107-115 ◽  
Author(s):  
Eiko Minamil ◽  
Hiroki Shibata ◽  
Yoshiki Nunoura ◽  
Masahiro Nomoto ◽  
Takeo Fukuda

The anticonvulsant effects of Shitei- To and its components on maximal electroshock seizures and chemical convulsions were examined. Shitei-To significantly prolonged the latency to bicuculline (2.0 mg/kg, s.c.)-induced clonic convulsions. Repeated treatment with Shitei-To also significantly prolonged the latency to strychnine (1.5 mg/kg, i.p.)- and pentylenetetrazol (90 mg/kg, i.p.)-induced clonic convulsions. On the other hand, Shitei-To had no effect on maximal electroshock seizures. Of the components of Shitei-To, Shitei had almost the same effect as Shitei-To against the clonic convulsions induced by the three chemical agents tested. These findings suggest that Shitei-To has anticonvulsant effects.


2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Hong Meng ◽  
Jiarui Li ◽  
Yinmao Dong ◽  
Yifan He ◽  
Hankun Ren ◽  
...  

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