Efficacy of Shitei-To, a Traditional Chinese Medicine Formulation, Against Convulsions in Mice

1999 ◽  
Vol 27 (01) ◽  
pp. 107-115 ◽  
Author(s):  
Eiko Minamil ◽  
Hiroki Shibata ◽  
Yoshiki Nunoura ◽  
Masahiro Nomoto ◽  
Takeo Fukuda
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
The Other ◽  
Repeated Treatment ◽  
Maximal Electroshock ◽  
Chemical Agents ◽  
Clonic Convulsions ◽  
Traditional Chinese Medicine Formulation ◽  
Electroshock Seizures ◽  
Anticonvulsant Effects

The anticonvulsant effects of Shitei- To and its components on maximal electroshock seizures and chemical convulsions were examined. Shitei-To significantly prolonged the latency to bicuculline (2.0 mg/kg, s.c.)-induced clonic convulsions. Repeated treatment with Shitei-To also significantly prolonged the latency to strychnine (1.5 mg/kg, i.p.)- and pentylenetetrazol (90 mg/kg, i.p.)-induced clonic convulsions. On the other hand, Shitei-To had no effect on maximal electroshock seizures. Of the components of Shitei-To, Shitei had almost the same effect as Shitei-To against the clonic convulsions induced by the three chemical agents tested. These findings suggest that Shitei-To has anticonvulsant effects.

scholarly journals Bilateral Integrative Medicine, Obviously

2006 ◽  
Vol 3 (2) ◽  
pp. 279-282 ◽  
Author(s):  
Steven H. Stumpf ◽  
Simon J. Shapiro
Keyword(s):  
Medical Education ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Integrative Medicine ◽  
The Other ◽  
Educational Model ◽  
Profound Impact ◽  
Integrative Education ◽  
Education Model ◽  
New Generation

Unstated and unacknowledged bias has a profound impact on the nature and implementation of integrative education models. Integrative education is the process of training conventional biomedical and traditional Chinese medicine practitioners in each tradition such that patient care may be effectively coordinated. A bilateral education model ensures that students in each tradition are cross-taught by experts from the ‘other’ tradition, imparting knowledge and values in unison. Acculturation is foundational to bilateral integrative medical education and practice. Principles are discussed for an open-minded bilateral educational model that can result in a new generation of integrative medicine teachers.

scholarly journals Arsenic Bioaccessibility of Realgar Influenced by the Other Traditional Chinese Medicines in Niuhuang Jiedu Tablet and the Roles of Gut Microbiota

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Wenfeng Xu ◽  
Shuo Xu ◽  
Shanshan Zhang ◽  
Xuejun Wu ◽  
Pengfei Jin
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Gut Microbiota ◽  
Incubation Medium ◽  
Toxic Elements ◽  
The Other ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Scutellariae Radix

Niuhuang Jiedu tablet (NJT), a realgar (As2S2) containing Traditional Chinese Medicine (TCM), is a well-known formula. The safety of NJT is of growing concern since arsenic (As) is considered as one of the most toxic elements. NJT was demonstrated to be safer than realgar by our previous experiments and some other studies. The toxicity of realgar has been shown to be related to the amount of soluble or bioaccessible arsenic. In this study, the influences of the other TCMs in NJT on the bioaccessibility of arsenic from realgar, and the roles of gut microbiota during this process were investigated in vitro. Results showed that Dahuang (Rhei Radix et Rhizoma), Huangqin (Scutellariae Radix), Jiegeng (Platycodonis Radix), and Gancao (Glycyrrhizae Radix et Rhizoma) could significantly reduce the bioaccessibility of arsenic from realgar in artificial gastrointestinal fluids. Gut microbiota played an important role in decreasing the bioaccessibility of realgar because it was demonstrated to be able to absorb the soluble arsenic from realgar in the incubation medium. Dahuang, Huangqin, and Jiegeng could modulate the gut microbiota to enhance its arsenic absorption activity.

scholarly journals Poly traditional Chinese medicine formulation prepared with skin moisturizing properties

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Hong Meng ◽  
Jiarui Li ◽  
Yinmao Dong ◽  
Yifan He ◽  
Hankun Ren ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Traditional Chinese Medicine Formulation

scholarly journals Study on Incompatibility of Traditional Chinese Medicine: Evidence from Formula Network, Chemical Space, and Metabolism Room

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Wei Long ◽  
Xiao-Dong Zhang ◽  
Hong-Ying Wu ◽  
Jin Jin ◽  
Guang-Yun Yu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Complex Network ◽  
Chemical Space ◽  
Average Distance ◽  
Average Degree ◽  
Clustering Coefficient ◽  
The Other ◽  
Network Diameter ◽  
Lines Of Evidence

A traditional Chinese medicine (TCM) formula network including 362 TCM formulas was built by using complex network methodologies. The properties of this network were analyzed including network diameter, average distance, clustering coefficient, and average degree. Meanwhile, we built a TCM chemical space and a TCM metabolism room under the theory of chemical space. The properties of chemical space and metabolism room were calculated and analyzed. The properties of the medicine pairs in “eighteen antagonisms and nineteen mutual inhibitors,” an ancient rule for TCM incompatibility, were studied based on the TCM formula network, chemical space, and metabolism room. The results showed that the properties of these incompatible medicine pairs are different from those of the other TCM based on the analysis of the TCM formula network, chemical space, and metabolism room. The lines of evidence derived from our work demonstrated that the ancient rule of TCM incompatibility, “eighteen antagonisms and nineteen mutual inhibitors,” is probably scientifically based.

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