Structural analysis of epolactaene derivatives as DNA polymerase inhibitors and anti-inflammatory compounds

2005 ◽  
Author(s):  
Yoshiyuki Mizushina ◽  
Kouji Kuramochi ◽  
Hiroshi Ikawa ◽  
Isoko Kuriyama ◽  
Noriko Shimazaki ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Dna Polymerase ◽  
Polymerase Inhibitors ◽  
Anti Inflammatory

scholarly journals Screening of Mammalian DNA Polymerase Inhibitors from Rosemary Leaves and Analysis of the Anti-inflammatory and Antiallergic Effects of the Isolated Compounds

2014 ◽  
Vol 20 (4) ◽  
pp. 829-840 ◽  
Author(s):  
Yoshiyuki Mizushina ◽  
Takefumi Onodera ◽  
Isoko Kuriyama ◽  
Hiroto Nakayama ◽  
Keiichiro Sugimoto ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Polymerase Inhibitors ◽  
Anti Inflammatory

Structural analysis of catechin derivatives as mammalian DNA polymerase inhibitors

2005 ◽  
Vol 333 (1) ◽  
pp. 101-109 ◽  
Author(s):  
Yoshiyuki Mizushina ◽  
Akiko Saito ◽  
Akira Tanaka ◽  
Noriyuki Nakajima ◽  
Isoko Kuriyama ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Dna Polymerase ◽  
Polymerase Inhibitors

scholarly journals Effects of Intermediates between Vitamins K2 and K3 on Mammalian DNA Polymerase Inhibition and Anti-Inflammatory Activity

2011 ◽  
Vol 12 (2) ◽  
pp. 1115-1132 ◽  
Author(s):  
Yoshiyuki Mizushina ◽  
Jun Maeda ◽  
Yasuhiro Irino ◽  
Masayuki Nishida ◽  
Shin Nishiumi ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Inflammatory Activity ◽  
Anti Inflammatory

scholarly journals Structural analysis of point mutations at theVaccinia virusA20/D4 interface

2016 ◽  
Vol 72 (9) ◽  
pp. 687-691 ◽  
Author(s):  
Céline Contesto-Richefeu ◽  
Nicolas Tarbouriech ◽  
Xavier Brazzolotto ◽  
Wim P. Burmeister ◽  
Christophe N. Peyrefitte ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Amino Acids ◽  
Structural Analysis ◽  
Complex Formation ◽  
Dna Polymerase ◽  
Point Mutations ◽  
Conformational Space ◽  
Uracil Dna Glycosylase ◽  
Dimerization Interface ◽  
Solvation Parameters

TheVaccinia viruspolymerase holoenzyme is composed of three subunits: E9, the catalytic DNA polymerase subunit; D4, a uracil-DNA glycosylase; and A20, a protein with no known enzymatic activity. The D4/A20 heterodimer is the DNA polymerase cofactor, the function of which is essential for processive DNA synthesis. The recent crystal structure of D4 bound to the first 50 amino acids of A20 (D4/A201–50) revealed the importance of three residues, forming a cation–π interaction at the dimerization interface, for complex formation. These are Arg167 and Pro173 of D4 and Trp43 of A20. Here, the crystal structures of the three mutants D4-R167A/A201–50, D4-P173G/A201–50and D4/A201–50-W43A are presented. The D4/A20 interface of the three structures has been analysed for atomic solvation parameters and cation–π interactions. This study confirms previous biochemical data and also points out the importance for stability of the restrained conformational space of Pro173. Moreover, these new structures will be useful for the design and rational improvement of known molecules targeting the D4/A20 interface.

Structure–function relationship of synthetic sulfoquinovosyl-acylglycerols as mammalian DNA polymerase inhibitors

2002 ◽  
Vol 403 (2) ◽  
pp. 229-236 ◽  
Author(s):  
Chikako Murakami ◽  
Takayuki Yamazaki ◽  
Shinya Hanashima ◽  
Shunya Takahashi ◽  
Keisuke Ohta ◽  
...  
Keyword(s):  
Structure Function ◽  
Dna Polymerase ◽  
Polymerase Inhibitors ◽  
Structure Function Relationship ◽  
Function Relationship ◽  
Relationship Of

Inhibition of DNA polymerase λ and associated inflammatory activities of extracts from steamed germinated soybeans

2014 ◽  
Vol 5 (4) ◽  
pp. 696-704 ◽  
Author(s):  
Yoshiyuki Mizushina ◽  
Isoko Kuriyama ◽  
Hiromi Yoshida
Keyword(s):  
Dna Polymerase ◽  
Inflammatory Activity ◽  
Soybean Extract ◽  
Dna Polymerase Λ ◽  
Anti Inflammatory ◽  
Germinated Soybean

The two glucosyl compounds from the steamed germinated soybean extract had anti-inflammatory activity based on DNA polymerase λ inhibition.

Effect of DNA polymerase inhibitors on the replication of human cytomegalovirus

1985 ◽  
Vol 84-84 (1-2) ◽  
pp. 129-134 ◽  
Author(s):  
E. G�ncz�l ◽  
S. A. Plotkin
Keyword(s):  
Dna Polymerase ◽  
Human Cytomegalovirus ◽  
Polymerase Inhibitors
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