scholarly journals Oxidized-low density lipoprotein accumulates cholesterol esters via the PKCα-adipophilin-ACAT1 pathway in RAW264.7 cells

2015 ◽  
Vol 12 (3) ◽  
pp. 3599-3606 ◽  
Author(s):  
YUNCHENG QIAO ◽  
DONGMING GUO ◽  
LEI MENG ◽  
QINGNAN LIU ◽  
XIAOHUI LIU ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Raw264.7 Cells ◽  
Low Density ◽  
Cholesterol Esters ◽  
Oxidized Low Density Lipoprotein

miR-155 inhibits oxidized low-density lipoprotein-induced apoptosis of RAW264.7 cells

2013 ◽  
Vol 382 (1-2) ◽  
pp. 253-261 ◽  
Author(s):  
Guo-fu Zhu ◽  
Li-xia Yang ◽  
Rui-wei Guo ◽  
Hong Liu ◽  
Yan-kun Shi ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Raw264.7 Cells ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Induced Apoptosis

Intralysosomal Accumulation of Colloidal Gold-Low Density Lipoprotein Conjugates in Chloroquine-Treated Fibroblasts

1985 ◽  
Vol 43 ◽  
pp. 546-547 ◽  
Author(s):  
Dean A. Handley ◽  
Cynthia M. Arbeeny ◽  
Larry D. Witte
Keyword(s):  
Colloidal Gold ◽  
Cultured Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coated Vesicle ◽  
Low Density ◽  
Cholesterol Esters ◽  
Cultured Fibroblasts ◽  
Surface Receptors ◽  
Ldl Particles

Low density lipoproteins (LDL) are the major cholesterol carrying particles in the blood. Using cultured cells, it has been shown that LDL particles interact with specific surface receptors and are internalized via a coated pit-coated vesicle pathway for lysosomal catabolism. This (Pathway has been visualized using LDL labeled to ferritin or colloidal gold. It is now recognized that certain lysomotropic agents, such as chloroquine, inhibit lysosomal enzymes that degrade protein and cholesterol esters. By interrupting cholesterol ester hydrolysis, chloroquine treatment results in lysosomal accumulation of cholesterol esters from internalized LDL. Using LDL conjugated to colloidal gold, we have examined the ultrastructural effects of chloroquine on lipoprotein uptake by normal cultured fibroblasts.

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