scholarly journals PA-MSHA inhibits proliferation and induces apoptosis in human non-small cell lung cancer cell lines with different genotypes

2016 ◽  
Vol 14 (6) ◽  
pp. 5369-5376
Author(s):  
Xinmin Zhao ◽  
Xianghua Wu ◽  
Wen Yu ◽  
Xuwei Cai ◽  
Qi Liu ◽  
...  
2016 ◽  
Vol 375 (2) ◽  
pp. 313-322 ◽  
Author(s):  
Christophe Deben ◽  
Filip Lardon ◽  
An Wouters ◽  
Ken Op de Beeck ◽  
Jolien Van den Bossche ◽  
...  

1988 ◽  
Vol 8 (1) ◽  
pp. 186-195
Author(s):  
F Kaye ◽  
J Battey ◽  
M Nau ◽  
B Brooks ◽  
E Seifter ◽  
...  

We analyzed in detail the structure of the L-myc gene isolated from human placental DNA and characterized its expression in several small-cell lung cancer cell lines. The gene is composed of three exons and two introns spanning 6.6 kilobases in human DNA. Several distinct mRNA species are produced in all small-cell lung cancer cell lines that express L-myc. These transcripts are generated from a single gene by alternative splicing of introns 1 and 2 and by use of alternative polyadenylation signals. In some mRNAs there is a long open reading frame with a predicted translated protein of 364 residues. Amino acid sequence comparison with c-myc and N-myc demonstrated multiple discrete regions with extensive homology. In contrast, other mRNA transcripts, generated by alternative processing, could encode a truncated protein with a novel carboxy-terminal end.


2019 ◽  
Vol 143 ◽  
pp. 106344 ◽  
Author(s):  
Erika Terzuoli ◽  
Filomena Costanza ◽  
Valerio Ciccone ◽  
Marina Ziche ◽  
Lucia Morbidelli ◽  
...  

2007 ◽  
Vol 14 (9) ◽  
pp. 2678-2684 ◽  
Author(s):  
Mahmood Alam ◽  
Jiang Huai Wang ◽  
John Calvin Coffey ◽  
Syed Suhail Qadri ◽  
Aonghus O’Donnell ◽  
...  

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