Salivary Gland Swelling in Wegener’s Granulomatosis: A Rare Cause of a Frequent Symptom

We present the case of a previously healthy 59-year-old man who was under treatment for scleritis and episcleritis when he developed a parotid-gland swelling and pus-producing sinus. On surgical exploration, the features were those of a parotid abscess, but the lesion not only failed to heal post-operatively but increased in size very significantly. There was also severe necrotizing keratitis of the eyes. Due to clinical suspicion and a positive antineutrophil cytoplasmic antibodies test, Wegener’s granulomatosis was diagnosed and the patient successfully treated with cyclophosphamide and steroids. Previously, a number of cases of Wegener’s granulomatosis causing salivary-gland swelling have been reported in the literature; this is the first case in which the disease has masqueraded as a parotid abscess.

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Salivary Gland Involvement in Wegener's Granulomatosis

Archives of Otolaryngology - Head and Neck Surgery ◽

10.1001/archotol.1991.01870140106018 ◽

1991 ◽

Vol 117 (2) ◽

pp. 218-223 ◽

Cited By ~ 34

Author(s):

U. Specks ◽

T. V. Colby ◽

K. D. Olsen ◽

R. A. DeRemee

Keyword(s):

Salivary Gland ◽

Wegener’S Granulomatosis ◽

Wegener's Granulomatosis

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Salivary gland involvement in Wegener's granulomatosis

Oral Surgery Oral Medicine Oral Pathology ◽

10.1016/0030-4220(94)90294-1 ◽

1994 ◽

Vol 77 (3) ◽

pp. 254-259 ◽

Cited By ~ 10

Author(s):

Joshua Lustmann ◽

Norberto Segal ◽

Alice Markitziu

Keyword(s):

Salivary Gland ◽

Wegener’S Granulomatosis ◽

Wegener's Granulomatosis

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Wegener's granulomatosis presenting as major salivary gland enlargement

The Journal of Laryngology & Otology ◽

10.1017/s0022215100134656 ◽

1996 ◽

Vol 110 (7) ◽

pp. 691-693 ◽

Cited By ~ 16

Author(s):

K. W. Ah-See ◽

K. McLaren ◽

A. G. D. Maran

Keyword(s):

Salivary Gland ◽

Immunosuppressive Therapy ◽

Gold Standard ◽

Wegener’S Granulomatosis ◽

Wegener's Granulomatosis ◽

Major Salivary Gland ◽

First Case ◽

Salivary Gland Enlargement ◽

Gland Enlargement ◽

Interpretation Of Results

AbstractSalivary gland involvement is rare in Wegener's granulomatosis. We report the first case of widespread major salivary gland enlargement as part of the presentation of this disease. A review of the few reported cases in the literature suggests that salivary gland involvement may be associated with a limited form of the disease and an improved prognosis. The anti-neutrophil cytoplasmic antibody (c-ANCA) assay remains the gold standard of diagnosis but care should be exercised in the interpretation of results. This patient responded well to current immunosuppressive therapy.

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Salivary gland involvement in Wegener's granulomatosis

The Journal of Laryngology & Otology ◽

10.1017/s0022215100112435 ◽

1990 ◽

Vol 104 (3) ◽

pp. 259-261 ◽

Cited By ~ 17

Author(s):

G. E. Murty ◽

B. T. Mains ◽

M. K. Bennett

Keyword(s):

Differential Diagnosis ◽

Salivary Gland ◽

Medical Treatment ◽

Wegener’S Granulomatosis ◽

Wegener's Granulomatosis ◽

Salivary Gland Enlargement ◽

Gland Enlargement

AbstractWhen salivary gland enlargement occurs in association with other ENT symptoms, Wegener's granulomatosis should be considered in the differential diagnosis. An early anti-neutrophil cytoplasmic antibody (ANCA) test may aid diagnosis. Effective medical treatment exists and, once the diagnosis has been made, therapeutic excision of the affected gland may be unnecessary. The fourth and fifth cases in the literature of salivary gland involvement in Wegener's granulomatosis are reported.

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