Salivary gland involvement in Wegener's granulomatosis

1990 ◽  
Vol 104 (3) ◽  
pp. 259-261 ◽  
Author(s):  
G. E. Murty ◽  
B. T. Mains ◽  
M. K. Bennett
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Medical Treatment ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Salivary Gland Enlargement ◽  
Gland Enlargement

AbstractWhen salivary gland enlargement occurs in association with other ENT symptoms, Wegener's granulomatosis should be considered in the differential diagnosis. An early anti-neutrophil cytoplasmic antibody (ANCA) test may aid diagnosis. Effective medical treatment exists and, once the diagnosis has been made, therapeutic excision of the affected gland may be unnecessary. The fourth and fifth cases in the literature of salivary gland involvement in Wegener's granulomatosis are reported.

Wegener's granulomatosis presenting as major salivary gland enlargement

1996 ◽  
Vol 110 (7) ◽  
pp. 691-693 ◽  
Author(s):  
K. W. Ah-See ◽  
K. McLaren ◽  
A. G. D. Maran
Keyword(s):  
Salivary Gland ◽  
Immunosuppressive Therapy ◽  
Gold Standard ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Major Salivary Gland ◽  
First Case ◽  
Salivary Gland Enlargement ◽  
Gland Enlargement ◽  
Interpretation Of Results

AbstractSalivary gland involvement is rare in Wegener's granulomatosis. We report the first case of widespread major salivary gland enlargement as part of the presentation of this disease. A review of the few reported cases in the literature suggests that salivary gland involvement may be associated with a limited form of the disease and an improved prognosis. The anti-neutrophil cytoplasmic antibody (c-ANCA) assay remains the gold standard of diagnosis but care should be exercised in the interpretation of results. This patient responded well to current immunosuppressive therapy.

Bilateral parotid and submandibular gland enlargement: rare features of Wegener’s granulomatosis

2003 ◽  
Vol 117 (2) ◽  
pp. 148-150 ◽  
Author(s):  
S. Y. Liu ◽  
A. C. Vlantis ◽  
W. C. Lee
Keyword(s):  
Wegener’S Granulomatosis ◽  
Unknown Origin ◽  
Wegener's Granulomatosis ◽  
Submandibular Salivary Gland ◽  
Fatal Disease ◽  
X Ray ◽  
Chest X Ray ◽  
Salivary Gland Enlargement ◽  
Gland Enlargement

Wegener’s granulomatosis is a potentially fatal disease of unknown origin affecting mainly the upper and lower respiratory tracts and kidneys. Prompt recognition of the more unusual presentations of the disease is necessary to ensure early treatment. We present a case of a 46-year-old female with bilateral submandibular and parotid gland enlargement.Parotid or submandibular salivary gland enlargement is a rare presenting feature of Wegener’s granulomatosis. Common to 80 per cent of these cases is nasal involvement, while ear pathology or lung lesions may occur in the remaining cases. The diagnosis is both clinical and pathological, biopsy of suspicious tissue, serum c-ANCA levels and a chest X-ray are valuable investigations. Treatment with immunosuppressive therapy is essential, and usually ensures a long-term remission.

Sinonasal T-cell Lymphoma and Wegener's Granulomatosis: Aspects in Early Differential Diagnosis

1996 ◽  
Vol 10 (4) ◽  
pp. 239-246
Author(s):  
Anders Cervin ◽  
Michael Dictor ◽  
Olof Kalm
Keyword(s):  
Differential Diagnosis ◽  
In Situ Hybridization ◽  
T Cell ◽  
Wegener’S Granulomatosis ◽  
Cell Lymphoma ◽  
Wegener's Granulomatosis ◽  
T Cell Lymphoma ◽  
Upper Airways ◽  
Gastrointestinal Complications

The clinical course of 12 patients with sinonasal T-cell lymphoma retrospectively diagnosed using in situ hybridization for Epstein-Barr virus RNA was compared with that of 10 recently treated patients with Wegener's granulomatosis (WG) in the upper airways. In particular, we studied the presenting signs and symptoms of both diseases, which commonly offer a problem in differential diagnosis at the clinical and pathological level. A bimodal age distribution was suggested in both T-cell lymphoma and WG; five patients with T-cell lymphoma developed disease prior to 40 years of age. Four of the 12 lymphoma patients had a history of “chronic rhinitis” for several years before developing mucosal ulcerations, which were initially unilateral, as opposed to the bilateral ulcerations in early sinonasal WG. Two lymphoma patients had swelling of the nasal dorsum and cheek. In contrast to the WG patients, cases of T-cell lymphoma did not exhibit associated clinical signs of arthritis, conjunctivitis, pulmonary lesions, or nephritis in the early stage of the disease. Nine of the patients with T-cell lymphoma presenting as a sinonasal lesion developed disseminated disease, variably including infiltrates in intestine, lung, CNS, and skin. Four of these patients died from gastrointestinal complications of their disease. We conclude that unilateral ulcerative or hemorrhagic polypoid mucosal lesions in the sinonasal area are suggestive of lymphoma rather than WG, and nonspecific symptoms, at least in Western patients, may be present as early as the second or third decade of life. A biopsy specimen containing T lymphocytes positive for the EBV ribonucleoprotein EBER1 on in situ hybridization offers reliable confirmation of T-cell lymphoma and is of differential diagnostic value against WG.

Salivary Gland Enlargement and Phenylbutazone

BMJ ◽  
1966 ◽  
Vol 2 (5505) ◽  
pp. 113-113 ◽  
Author(s):  
R. D. Rogers
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Enlargement ◽  
Gland Enlargement

Salivary gland enlargement and elevated serum amylase in bulimia nervosa

1999 ◽  
Vol 45 (11) ◽  
pp. 1520-1522 ◽  
Author(s):  
Eran D Metzger ◽  
Jeffrey M Levine ◽  
Colin R McArdle ◽  
Barbara E Wolfe ◽  
David C Jimerson
Keyword(s):  
Salivary Gland ◽  
Bulimia Nervosa ◽  
Serum Amylase ◽  
Elevated Serum ◽  
Salivary Gland Enlargement ◽  
Gland Enlargement

scholarly journals Salivary gland enlargement and sialorrhoea in dogs with spirocercosis: A retrospective and prospective study of 298 cases

2012 ◽  
Vol 83 (1) ◽  
Author(s):  
Liesel L. Van der Merwe ◽  
Jevan Christie ◽  
Sarah J. Clift ◽  
Eran Dvir
Keyword(s):  
Salivary Gland ◽  
Prospective Study ◽  
Salivary Glands ◽  
Clinical Signs ◽  
Neoplastic Transformation ◽  
Whitney Test ◽  
Mann Whitney Test ◽  
Salivary Gland Enlargement ◽  
Canine Spirocercosis ◽  
Gland Enlargement

This longitudinal cross-sectional clinical study investigated the incidence of sialorrhoea in dogs with spirocercosis and determined whether breed, body weight and the extent of the oesophageal involvement was associated with this presentation. A retrospective analysis was performed on the medical records of 233 dogs and information pertaining to 65 dogs was collected as part of a prospective study. All the animals were client-owned. Patients from the retrospective study underwent thoracic radiography or oesophageal endoscopy to diagnose and characterise the infection and were placed on therapy with a macrocyclic lactone, whereas the patients in the prospective study had both radiography and endoscopy routinely performed and biopsies of the oesophageal nodules collected where possible. Tru-cut biopsies of affected salivary glands were taken in 10 of 13 patients demonstrating clinical signs of sialorrhoea and salivary gland enlargement. The entire salivary gland was sectioned in an additional three dogs with spirocercosis and no sialorrhoea that were presented for post mortem examination. Sialorrhoea was present in 33/298 cases (11%). Fox terrier breeds were over-represented in the patients with sialorrhoea, comprising 36% of cases, whereas they only comprised 1.5% of the patients without sialorrhoea (p < 0.001, chi squared test) and 5% of the combined group. Dogs weighing 12 kg or less were significantly over-represented in the sialorrhoea group, 69% versus 19.5% (p < 0.001, chi square test). Age was not significantly different between the two groups (p < 0.08, Mann-Whitney test). The number of oesophageal nodules per case was significantly higher in the non-sialorrhoea cases (p = 0.048, Mann-Whitney test). The prevalence of distal oesophageal and lower oesophageal sphincter involvement, and neoplastic transformation of the nodules were not statistically different between the two groups. None of the fox terriers in either group showed neoplastic transformation of the parasitic nodules even though they were over-represented as a breed. Mandibular salivary glands were affected in 86% of cases showing sialorrhoea. Histopathology revealed acinar hyperplasia in all cases with concurrent necrosis detected in only two cases.Sialorrhoea and salivary gland enlargement has an incidence of 11% (33/298 cases) in canine spirocercosis. Small breeds (≤ 12 kg) and particularly fox terrier breeds are over-represented in the group demonstrating sialorrhoea and this appeared to be the only risk factor.The conclusion was that sialorrhoea secondary to canine spirocercosis occurs frequently and its presence should prompt further investigation for oesophageal and gastro-intestinal disease. Severely affected patients can be managed with phenobarbitone to control the dysphagia in addition to the routine macrocyclic lactones treatment.

scholarly journals Wegener’s granulomatosis mimicking a parotid abscess

2005 ◽  
Vol 119 (9) ◽  
pp. 746-749 ◽  
Author(s):  
G L Jones ◽  
A D Lukaris ◽  
H V Prabhu ◽  
M J K M Brown ◽  
J Bondeson
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Clinical Suspicion ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Surgical Exploration ◽  
First Case

We present the case of a previously healthy 59-year-old man who was under treatment for scleritis and episcleritis when he developed a parotid-gland swelling and pus-producing sinus. On surgical exploration, the features were those of a parotid abscess, but the lesion not only failed to heal post-operatively but increased in size very significantly. There was also severe necrotizing keratitis of the eyes. Due to clinical suspicion and a positive antineutrophil cytoplasmic antibodies test, Wegener’s granulomatosis was diagnosed and the patient successfully treated with cyclophosphamide and steroids. Previously, a number of cases of Wegener’s granulomatosis causing salivary-gland swelling have been reported in the literature; this is the first case in which the disease has masqueraded as a parotid abscess.

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