scholarly journals HLA-B*5801 Should Be Used to Screen for Risk of Stevens-Johnson Syndrome in Family Members of Han Chinese Patients Commencing Allopurinol Therapy

2013 ◽  
Vol 40 (1) ◽  
pp. 96.2-97 ◽  
Author(s):  
MING-HAN HUGO LEE ◽  
SOPHIE LENA STOCKER ◽  
KENNETH MAPSON WILLIAMS ◽  
RICHARD OSBORNE DAY
Keyword(s):  
Family Members ◽  
Han Chinese ◽  
Chinese Patients ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome

Human leucocyte antigen association of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications in Han Chinese

2021 ◽  
pp. bjophthalmol-2020-317105
Author(s):  
Kevin Sheng-Kai Ma ◽  
Wen Hung Chung ◽  
Yi-Jen Hsueh ◽  
Shin-Yi Chen ◽  
Katsushi Tokunaga ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Allele Frequency ◽  
Carrier Frequency ◽  
Human Leucocyte Antigen ◽  
Han Chinese ◽  
Chinese Patients ◽  
Stevens Johnson Syndrome ◽  
Ocular Complications ◽  
Hla Polymorphism ◽  
Johnson Syndrome

Background/aimsStevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) induced by cold medicine (CM) may result in severe ocular complications (SOCs). The purpose of this study was to investigate the human leucocyte antigen (HLA) polymorphism pattern in CM-induced patients with SJS/TEN developing SOCs.MethodsAll participants, including patients with SJS/TEN (n=33) and control patients (n=98), were enrolled through visits to the clinic from 2016 to 2017. SOCs were diagnosed (n=26) via a chart review or eye examination. Patient saliva was collected with commercialised kits and genotyped with PCR assays followed by hybridisation with sequence-specific oligonucleotide (SSO) probes (PCR-SSO) using commercial bead-based typing kits.ResultsIn all patients with SJS/TEN with SOCs, the HLA-A*02:07 carrier frequency was significantly higher than that in controls (OR=3.24, 95% CI=1.09 to 9.60, p=0.049), as was the genotype frequency (OR=3.89, 95% CI=1.49 to 10.16, p=0.007). In patients with CM-SJS/TEN with SOCs, the HLA-A*02:07 carrier frequency was higher than that in controls (OR=5.56, 95% CI=1.52 to 20.00, p=0.016), as was the allele frequency (OR=6.67, 95% CI=2.33 to 20.00, p=0.001). In patients with CM-SJS/TEN with SOCs, the HLA-B*46:01 allele frequency was significantly higher than that in controls (OR=3.85, 95% CI=1.52 to 10.00, p=0.008).ConclusionsThe HLA-A*02:07 and HLA-B*46:01 alleles were significantly associated with SOCs among Han Chinese patients with CM-SJS/TEN. These findings demonstrate the genetic diversity in SJS pathogenesis among different ethnic groups.

Common risk allele in aromatic antiepileptic-drug induced Stevens–Johnson syndrome and toxic epidermal necrolysis in Han Chinese

2010 ◽  
Vol 11 (3) ◽  
pp. 349-356 ◽  
Author(s):  
Shuen-Iu Hung ◽  
Wen-Hung Chung ◽  
Zhi-Sheng Liu ◽  
Chien-Hsiun Chen ◽  
Mo-Song Hsih ◽  
...  
Keyword(s):  
Antiepileptic Drug ◽  
Toxic Epidermal Necrolysis ◽  
Risk Allele ◽  
Han Chinese ◽  
Stevens Johnson Syndrome ◽  
Drug Induced ◽  
Johnson Syndrome

HLA-B*1502 genotyping in two Chinese patients with phenytoin-induced Stevens–Johnson syndrome

2011 ◽  
Vol 20 (2) ◽  
pp. 390-391 ◽  
Author(s):  
Fu-Li Min ◽  
Yi-Wu Shi ◽  
Xiao-Rong Liu ◽  
Wei-Ping Liao
Keyword(s):  
Chinese Patients ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome

scholarly journals HLA-A*24:02 as a common risk factor for antiepileptic drug–induced cutaneous adverse reactions

Neurology ◽  
2017 ◽  
Vol 88 (23) ◽  
pp. 2183-2191 ◽  
Author(s):  
Yi-Wu Shi ◽  
Fu-Li Min ◽  
Dong Zhou ◽  
Bin Qin ◽  
Juan Wang ◽  
...  
Keyword(s):  
Risk Factor ◽  
Antiepileptic Drug ◽  
Antiepileptic Drugs ◽  
Adverse Reactions ◽  
Han Chinese ◽  
Stevens Johnson Syndrome ◽  
Drug Induced ◽  
Maculopapular Eruption ◽  
Johnson Syndrome ◽  
Cutaneous Adverse Reactions

Objective:To investigate the involvement of human leukocyte antigen (HLA) loci in aromatic antiepileptic drug–induced cutaneous adverse reactions.Methods:A case-control study was performed to detect HLA loci involved in aromatic antiepileptic drug–induced Stevens-Johnson syndrome in a southern Han Chinese population. Between January 1, 2006, and December 31, 2015, 91 cases of Stevens-Johnson syndrome induced by aromatic antiepileptic drugs and 322 matched drug-tolerant controls were enrolled from 8 centers. Important genotypes were replicated in cases with maculopapular eruption and in the meta-analyses of data from other populations. Sequence-based typing determined the HLA-A, HLA-B, HLA-C, and HLA-DRB1 genotypes.Results:HLA-B*15:02 was confirmed as strongly associated with carbamazepine-induced Stevens-Johnson syndrome (p = 5.63 × 10−15). In addition, HLA-A*24:02 was associated significantly with Stevens-Johnson syndrome induced by the aromatic antiepileptic drugs as a group (p = 1.02 × 10−5) and by individual drugs (carbamazepine p = 0.015, lamotrigine p = 0.005, phenytoin p = 0.027). Logistic regression analysis revealed a multiplicative interaction between HLA-B*15:02 and HLA-A*24:02. Positivity for HLA-A*24:02 and/or HLA-B*15:02 showed a sensitivity of 72.5% and a specificity of 69.0%. The presence of HLA-A*24:02 in cases with maculopapular exanthema was also significantly higher than in controls (p = 0.023). Meta-analysis of data from Japan, Korea, Malaysia, Mexico, Norway, and China revealed a similar association.Conclusions:HLA-A*24:02 is a common genetic risk factor for cutaneous adverse reactions induced by aromatic antiepileptic drugs in the southern Han Chinese and possibly other ethnic populations. Pretreatment screening is recommended for people in southern China.

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