scholarly journals Minor Salivary Gland Inflammatory Lesions in Sjögren Syndrome: Do They Evolve?

2013 ◽  
Vol 40 (9) ◽  
pp. 1566-1571 ◽  
Author(s):  
Efstathia K. Kapsogeorgou ◽  
Maria I. Christodoulou ◽  
Demosthenes B. Panagiotakos ◽  
Spyros Paikos ◽  
Anna Tassidou ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Minor Salivary Gland ◽  
Cell Types ◽  
Sjögren Syndrome ◽  
Time Interval ◽  
Sjogren Syndrome ◽  
T And B Cells ◽  
Biopsy Specimens ◽  
Lymphocytic Infiltrates ◽  
Significant Disease

Objective.The lymphocytic infiltrates of minor salivary gland (MSG) lesions of Sjögren syndrome (SS) vary in grade and composition and are generally thought to develop in stepwise manner. Their progression over time is not well defined.Methods.We studied repetitive MSG biopsy specimens from 28 patients with primary SS.Results.The infiltration grade and prevalence of the major infiltrating cell types (T and B cells, macrophages, dendritic cells, natural killer cells) remained largely unchanged during a median 55 month biopsy time interval followup (quartiles 42–81).Conclusion.We found significant disease progression involving the development of mucosa-associated lymphoid tissue lymphoma in patients expressing adverse serologic prognostic factors, such as low serum C4 complement levels and cryoglobulinemia.

Comparison of Labial Minor Salivary Gland Biopsies from Childhood Sjögren Syndrome and Age-matched Controls

2014 ◽  
Vol 41 (6) ◽  
pp. 1178-1182 ◽  
Author(s):  
Naoto Yokogawa ◽  
Scott M. Lieberman ◽  
Faizan Alawi ◽  
Sharon Bout-Tabaku ◽  
Marta Guttenberg ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Minor Salivary Gland ◽  
Sjögren Syndrome ◽  
Classification Criteria ◽  
Sjogren Syndrome ◽  
Labial Salivary Gland ◽  
Focus Score ◽  
Salivary Gland Tissue ◽  
Gland Tissue ◽  
Control Samples

Objective.To determine an appropriate focus score cutoff for childhood Sjögren syndrome (SS).Methods.Labial salivary gland tissue from specimens from children with SS and age-matched controls was retrospectively identified and reviewed by a blinded oral pathologist.Results.The presence of any focal sialadenitis (focus score > 0 foci/4 mm2) was common among childhood SS samples but present in only 1 of 8 control samples.Conclusion.The presence of any focal lymphocytic sialadenitis in minor labial salivary gland tissue is suggestive of childhood SS and should be included in future childhood SS-specific diagnostic or classification criteria.

scholarly journals Accuracy of minor salivary gland biopsy in the diagnosis of Sjögren syndrome

2021 ◽  
Vol 122 (07) ◽  
pp. 454-460
Author(s):  
R. Edelstein ◽  
G. E. Kilipiris ◽  
K. Machalekova ◽  
E. Mouzalini ◽  
A. Slobodianuk ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Minor Salivary Gland ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Minor Salivary Gland Biopsy ◽  
Salivary Gland Biopsy

scholarly journals Minor Salivary Gland Biopsy To Detect Primary Sjögren Syndrome in Patients With Interstitial Lung Disease

CHEST Journal ◽  
2009 ◽  
Vol 136 (4) ◽  
pp. 1072-1078 ◽  
Author(s):  
Aryeh Fischer ◽  
Jeffrey J. Swigris ◽  
Roland M. du Bois ◽  
Steve D. Groshong ◽  
Carlyne D. Cool ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Minor Salivary Gland ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Minor Salivary Gland Biopsy ◽  
Primary Sjögren Syndrome ◽  
Salivary Gland Biopsy

scholarly journals Correlation and Accuracy of Labial Minor Salivary Gland Biopsy in the Establishment of Diagnosis in Patients with Suspected Sjögren’s Syndrome

2018 ◽  
Vol 2 (3) ◽  
pp. 122-131
Keyword(s):  
Salivary Gland ◽  
Diagnostic Tool ◽  
Minor Salivary Gland ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Minor Salivary Gland Biopsy ◽  
Salivary Gland Biopsy ◽  
Lip Biopsy

Purpose. The goal of this paper is to find out the correlation, and evaluate the accuracy of labial minor salivary gland biopsy as a diagnostic tool in the multidisciplinary management of patients with Sjögren’s syndrome. Patients and Methods. Thirty seven patients referred to our outpatient office between January 2016 and December 2017 from a rheumatologist for biopsy examination, as part of the complex diagnostic plan for suspected Sjögren syndrome were included in the current study. Each specimen was examined histomorphometrically by the pathologist to calculate the focus score describing the degree of salivary gland inflammatory infiltration. Results. From the total number of patients, 25 presented with an established Sjögren syndrome diagnosis by fulfilling the revised American-European criteria. From those 15 had a positive lip biopsy. The rest 10 patients from the total group who were diagnosed with Sjögren syndrome based on the same criteria had a negative lip biopsy. Conclusion. The labial minor salivary gland biopsy is a valuable diagnostic tool to establish the diagnosis of Sjögren syndrome. However, a positive biopsy result must always be correlated with all the other diagnostic criteria to prove the exact diagnosis.

Tongue Atrophy in Sjögren Syndrome Patients with Mucosa-associated Lymphoid Tissue Lymphoma: Autoimmune Epithelitis beyond the Epithelial Cells of Salivary Glands?

2018 ◽  
Vol 45 (11) ◽  
pp. 1565-1571 ◽  
Author(s):  
Evangelia Zampeli ◽  
Eleni-Marina Kalogirou ◽  
Evangelia Piperi ◽  
Clio P. Mavragani ◽  
Haralampos M. Moutsopoulos
Keyword(s):  
Salivary Gland ◽  
Lymphoid Tissue ◽  
Megaloblastic Anemia ◽  
Oral Candidiasis ◽  
Minor Salivary Gland ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Minor Salivary Gland Biopsy ◽  
Clinical Indicators ◽  
Fissured Tongue

Objective.Primary Sjögren syndrome (pSS), an autoimmune epithelitis, bears the risk of evolving to non-Hodgkin lymphoma and most frequently to the mucosa-associated lymphoid tissue (MALT) subtype. Based on the observation that pSS patients with MALT present a more atrophic and more intensely fissured tongue, we aimed to semiquantify severity of tongue atrophy and clinically assess lingual appearance in pSS patients with and without MALT, and investigate whether tongue atrophy and fissured appearance could serve as clinical indicators/signs of MALT.Methods.A blinded complete oral examination was performed in pSS patients with and without MALT. Tongue atrophy was scored using a semiquantified atrophy score. Clinical and laboratory variables were recorded for all patients.Results.After excluding pSS patients with oral candidiasis, iron deficiency, and megaloblastic anemia, 19 pSS patients with salivary MALT were matched 1:3 for age, sex, and disease duration with 57 pSS patients without MALT. The pSS-MALT patients had increased prevalence of salivary gland enlargement, lymphadenopathy, monoclonal gammopathy, rheumatoid factor positivity, higher focus and Tarpley scores in the minor salivary gland biopsy, and hyposalivation, compared to the pSS non-MALT patients. A significantly higher prevalence of tongue atrophy (68% vs 30%, p = 0.006) and fissured tongue (89% vs 33%, p < 0.001) was observed in the former group. Multivariate analysis showed that fissured tongue appearance, hyposalivation, and lymphadenopathy associate independently with salivary MALT in pSS.Conclusion.These results suggest that pSS patients with lymphoid malignancy exhibit a more atrophic and more fissured tongue. This particular clinical tongue appearance can serve as an additional clinical sign for salivary MALT lymphoma in pSS patients.

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