Comparison of Labial Minor Salivary Gland Biopsies from Childhood Sjögren Syndrome and Age-matched Controls

2014 ◽  
Vol 41 (6) ◽  
pp. 1178-1182 ◽  
Author(s):  
Naoto Yokogawa ◽  
Scott M. Lieberman ◽  
Faizan Alawi ◽  
Sharon Bout-Tabaku ◽  
Marta Guttenberg ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Minor Salivary Gland ◽  
Sjögren Syndrome ◽  
Classification Criteria ◽  
Sjogren Syndrome ◽  
Labial Salivary Gland ◽  
Focus Score ◽  
Salivary Gland Tissue ◽  
Gland Tissue ◽  
Control Samples

Objective.To determine an appropriate focus score cutoff for childhood Sjögren syndrome (SS).Methods.Labial salivary gland tissue from specimens from children with SS and age-matched controls was retrospectively identified and reviewed by a blinded oral pathologist.Results.The presence of any focal sialadenitis (focus score > 0 foci/4 mm2) was common among childhood SS samples but present in only 1 of 8 control samples.Conclusion.The presence of any focal lymphocytic sialadenitis in minor labial salivary gland tissue is suggestive of childhood SS and should be included in future childhood SS-specific diagnostic or classification criteria.

scholarly journals Minor Salivary Gland Inflammatory Lesions in Sjögren Syndrome: Do They Evolve?

2013 ◽  
Vol 40 (9) ◽  
pp. 1566-1571 ◽  
Author(s):  
Efstathia K. Kapsogeorgou ◽  
Maria I. Christodoulou ◽  
Demosthenes B. Panagiotakos ◽  
Spyros Paikos ◽  
Anna Tassidou ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Minor Salivary Gland ◽  
Cell Types ◽  
Sjögren Syndrome ◽  
Time Interval ◽  
Sjogren Syndrome ◽  
T And B Cells ◽  
Biopsy Specimens ◽  
Lymphocytic Infiltrates ◽  
Significant Disease

Objective.The lymphocytic infiltrates of minor salivary gland (MSG) lesions of Sjögren syndrome (SS) vary in grade and composition and are generally thought to develop in stepwise manner. Their progression over time is not well defined.Methods.We studied repetitive MSG biopsy specimens from 28 patients with primary SS.Results.The infiltration grade and prevalence of the major infiltrating cell types (T and B cells, macrophages, dendritic cells, natural killer cells) remained largely unchanged during a median 55 month biopsy time interval followup (quartiles 42–81).Conclusion.We found significant disease progression involving the development of mucosa-associated lymphoid tissue lymphoma in patients expressing adverse serologic prognostic factors, such as low serum C4 complement levels and cryoglobulinemia.

SAT0553 Diagnostic Value of Quantitative Sialoscintigraphy Compared To Labial Salivary Gland Biopsy in Patients with Suspected Sjögren' Syndrome

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 869.2-869
Author(s):  
M. Garcia Gonzalez ◽  
H. Sanchez Perez ◽  
I. Ferraz Amaro ◽  
V. Hernandez Hernandez ◽  
B. Rodriguez Lozano ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Diagnostic Value ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Labial Salivary Gland ◽  
Labial Salivary Gland Biopsy ◽  
Salivary Gland Biopsy

scholarly journals Sjögren Syndrome without Focal Lymphocytic Infiltration of the Salivary Glands

2019 ◽  
Vol 47 (3) ◽  
pp. 394-399 ◽  
Author(s):  
Rohan Sharma ◽  
Kaustubh S. Chaudhari ◽  
Biji T. Kurien ◽  
Kiely Grundahl ◽  
Lida Radfar ◽  
...  
Keyword(s):  
Mononuclear Cells ◽  
Systemic Disease ◽  
Minor Salivary Gland ◽  
Sjögren Syndrome ◽  
Small Subset ◽  
Sjogren Syndrome ◽  
Peripheral Blood Mononuclear ◽  
Focus Score ◽  
Extraglandular Manifestations ◽  
Elevated Expression

ObjectivePrimary Sjögren syndrome (SS) is characterized by a focal lymphocytic infiltrate in exocrine glands. We describe patients who lacked this key feature.Methods.We evaluated patients with sicca in a comprehensive clinic at which medical, dental, and ophthalmological examinations were performed. All subjects underwent a minor salivary gland biopsy with focus score calculation. Extraglandular manifestations were also determined. We categorized subjects as high, intermediate, or low in terms of expression of interferon (IFN)-regulated genes.Results.About 20% (51 of 229, 22%) of those classified as having primary SS had a focus score of zero. Compared to those with anti-Ro positivity and a focus score > 1.0, the patients with focus score of zero (who by classification criteria must be anti-Ro–positive) were statistically less likely to have anti-La (or SSB) and elevated immunoglobulin, as well as less severe corneal staining. The focus score zero patients were less likely to have elevated expression of IFN-regulated genes in peripheral blood mononuclear cells than anti-Ro–positive SS patients with a focal salivary infiltrate.Conclusion.There are only a few clinical differences between patients with primary SS with focus score zero and those with both anti-Ro and a focus score > 1.0. The small subset of focus score zero patients tested did not have elevated expression of IFN-regulated genes, but did have systemic disease. Thus, extraglandular manifestations are perhaps more related to the presence of anti-Ro than increased IFN. This may have relevance to pathogenesis of SS.

scholarly journals Accuracy of minor salivary gland biopsy in the diagnosis of Sjögren syndrome

2021 ◽  
Vol 122 (07) ◽  
pp. 454-460
Author(s):  
R. Edelstein ◽  
G. E. Kilipiris ◽  
K. Machalekova ◽  
E. Mouzalini ◽  
A. Slobodianuk ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Minor Salivary Gland ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Minor Salivary Gland Biopsy ◽  
Salivary Gland Biopsy
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