Two Cases of Radiation-induced Sarcoma after Radiation Therapy in Nasopharyngeal Carcinoma

ObjectiveThis study aimed to develop a least absolute shrinkage and selection operator (LASSO)-based multivariable normal tissue complication probability (NTCP) model to predict radiation-induced xerostomia in patients with nasopharyngeal carcinoma (NPC) treated with comprehensive salivary gland–sparing helical tomotherapy technique.Methods and MaterialsLASSO with the extended bootstrapping technique was used to build multivariable NTCP models to predict factors of patient-reported xerostomia relieved by 50% and 80% compared with the level at the end of radiation therapy within 1 year and 2 years, R50-1year and R80-2years, in 203 patients with NPC. The model assessment was based on 10-fold cross-validation and the area under the receiver operating characteristic curve (AUC).ResultsThe prediction model by LASSO with 10-fold cross-validation showed that radiation-induced xerostomia recovery could be predicted by prognostic factors of R50-1year (age, gender, T stage, UICC/AJCC stage, parotid Dmean, oral cavity Dmean, and treatment options) and R80-2years (age, gender, T stage, UICC/AJCC stage, oral cavity Dmean, N stage, and treatment options). These prediction models also demonstrated a good performance by the AUC.ConclusionThe prediction models of R50-1year and R80-2years by LASSO with 10-fold cross-validation were recommended to validate the NTCP model before comprehensive salivary gland–sparing radiation therapy in patients with NPC.

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Intensity-modulated radiation therapy reduces radiation-induced trismus in patients with nasopharyngeal carcinoma

Cancer ◽

10.1002/cncr.25773 ◽

2011 ◽

Vol 117 (13) ◽

pp. 2910-2916 ◽

Cited By ~ 39

Author(s):

Yuan-Yuan Chen ◽

Chong Zhao ◽

Jin Wang ◽

Hong-Lian Ma ◽

Shu-Zheng Lai ◽

...

Keyword(s):

Radiation Therapy ◽

Nasopharyngeal Carcinoma ◽

Intensity Modulated Radiation Therapy ◽

Intensity Modulated ◽

Radiation Induced

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Effect of relevant factors on radiation‐induced nasopharyngeal ulcer in patients with primary nasopharyngeal carcinoma treated with intensity‐modulated radiation therapy

Laryngoscope Investigative Otolaryngology ◽

10.1002/lio2.365 ◽

2020 ◽

Vol 5 (2) ◽

pp. 228-234

Author(s):

Zhaodong Fei ◽

Taojun Chen ◽

Xiufang Qiu ◽

Chuanben Chen

Keyword(s):

Radiation Therapy ◽

Nasopharyngeal Carcinoma ◽

Intensity Modulated Radiation Therapy ◽

Intensity Modulated ◽

Radiation Induced ◽

Relevant Factors

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Temporal Lobe Necrosis Following Radiotherapy in Nasopharyngeal Carcinoma: New Insight Into the Management

Frontiers in Oncology ◽

10.3389/fonc.2020.593487 ◽

2021 ◽

Vol 10 ◽

Author(s):

Xin Zhou ◽

Peiyao Liu ◽

Xiaoshen Wang

Keyword(s):

Radiation Therapy ◽

Growth Factor ◽

Nasopharyngeal Carcinoma ◽

Temporal Lobe ◽

Intensity Modulated Radiation Therapy ◽

Therapeutic Interventions ◽

Humanized Monoclonal Antibody ◽

Temporal Lobe Necrosis ◽

Radiation Induced ◽

Endothelial Growth Factor

Cerebral radiation necrosis (CRN) is one of the most prominent sequelae following radiation therapy for nasopharyngeal carcinoma (NPC), which might have devastating effects on patients’ quality of life (QOL). Advances in histopathology and neuro-radiology have shed light on the management of CRN more comprehensively, yet effective therapeutic interventions are still lacking. CRN was once regarded as progressive and irreversible, however, in the past 20 years, with the application of intensity-modulated radiation therapy (IMRT), both the incidence and severity of CRN have declined. In addition, newly developed medical agents including bevacizumab-a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), nerve growth factor (NGF), monosialotetrahexosylganglioside (GM1), etc., have shown great potency in successfully reversing radiation-induced CRN. As temporal lobes are most frequently compromised in NPC patients, this review will summarize the state-of-the-art progress regarding the incidence, pathophysiology, prevention, treatment, and prognosis of temporal lobe necrosis (TLN) after IMRT in NPC.

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