Stereoselective Synthesis of Optically Active Diethanolamines Utilizing Diastereoselective Reaction of 1,3-Oxazolidines with Grignard Reagents

Heterocycles ◽  
1995 ◽  
Vol 41 (9) ◽  
pp. 2007 ◽  
Author(s):  
Kimio Higashiyama ◽  
Katuyuki Nakagawa ◽  
Hiroshi Takahashi
Keyword(s):  
Stereoselective Synthesis ◽  
Optically Active ◽  
Grignard Reagents ◽  
Diastereoselective Reaction

Stereoselective synthesis of optically active cyclopenta[c]pyridines and tetrahydropyridines

2012 ◽  
Vol 23 (9) ◽  
pp. 662-669 ◽  
Author(s):  
Serdar Sezer ◽  
Yasemin Gümrükçü ◽  
İrem Bakırcı ◽  
M. Yağız Ünver ◽  
Cihangir Tanyeli
Keyword(s):  
Stereoselective Synthesis ◽  
Optically Active

A new approach to the stereoselective synthesis of trans-3-carbamoyl-β-lactam moieties

2017 ◽  
Vol 41 (6) ◽  
pp. 2479-2489 ◽  
Author(s):  
Anna Zakaszewska ◽  
Ewelina Najda-Mocarska ◽  
Sławomir Makowiec
Keyword(s):  
Stereoselective Synthesis ◽  
Optically Active ◽  
Thermal Generation ◽  
New Approach

Optically active 1,4-disubstituted-3-carbamoyl-azetidinones are synthesized from 5-[(N-arylamino)(hydroxyl)methylene]-2,2-dimethyl-1,3-dioxa-4,6-diones and chiral aldimines via thermal generation of carbamoyl ketenes and subsequent [2+2] cycloaddition.

Diastereoselective Synthesis of Morpholine Derivatives from Grignard Reagents and N-Sulfinyl Imines

Synlett ◽  
2021 ◽  
Author(s):  
Eric P. A. Talbot ◽  
Joseph M. Bateman ◽  
Diana Chan ◽  
Mustafa Moroglu ◽  
Benjamin Rahemtulla
Keyword(s):  
Grignard Reagent ◽  
Stereoselective Synthesis ◽  
Grignard Reagents ◽  
Diastereoselective Synthesis ◽  
Step Process ◽  
Diastereoselective Addition ◽  
Morpholine Derivatives

The stereoselective synthesis of C3-substituted morpholine derivatives has been achieved through a two-step process involving diastereoselective addition of a Grignard reagent to a sulfinyl imine, followed by cyclization.

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