Tissue Oxygenation Monitoring as a Guide for Trauma Resuscitation

2016 ◽  
Vol 36 (3) ◽  
pp. 12-70 ◽  
Author(s):  
Cathy Mitchell

Hypoperfusion is the most common event preceding the onset of multiple organ dysfunction syndrome during trauma resuscitation. Detecting subtle changes in perfusion is crucial to ensure adequate tissue oxygenation and perfusion. Traditional methods of detecting physiological changes include measurements of blood pressure, heart rate, urine output, serum levels of lactate, mixed venous oxygen saturation, and central venous oxygen saturation. Continuous noninvasive monitoring of tissue oxygen saturation in muscle has the potential to indicate severity of shock, detect occult hypoperfusion, guide resuscitation, and be predictive of the need for interventions to prevent multiple organ dysfunction syndrome. Tissue oxygen saturation is being used in emergency departments, trauma rooms, operating rooms, and emergency medical services. Tissue oxygen saturation technology is just as effective as mixed venous oxygen saturation, central venous oxygen saturation, serum lactate, and Stewart approach with strong ion gap, yet tissue oxygen saturation assessment is also a direct, noninvasive microcirculatory measurement of oxygen saturation.

2019 ◽  
Vol 58 (5) ◽  
pp. 528-533 ◽  
Author(s):  
Ravi S. Samraj ◽  
Maria Kerrigan ◽  
Maria Mejia ◽  
Laura Wilson ◽  
James C. Fudge ◽  
...  

Purpose. Shock is associated with increased tissue oxygen extraction. Near-infrared spectroscopy–derived thenar muscle tissue oxygenation (StO2) levels can provide an estimate of the oxygen supply-demand balance at the tissue level. We hypothesized that thenar StO2 levels would correlate with central venous oxygen saturation (ScvO2) levels, the gold standard for global tissue oxygen extraction in the body. Methods. We prospectively enrolled 60 pediatric subjects admitted to pediatric intensive care unit or who underwent cardiac catheterization from September 2015 to March 2018. Thenar StO2 levels were measured using the InSpectra StO2 probe. Concurrent measurements of ScvO2 and peripheral tissue oxygenation (StO2) were achieved through simultaneous testing. For ScvO2, a central line placed in the superior vena cava was utilized for serum specimen collection, while the InSpectra probe recorded StO2 measurements from the thenar eminence of the patient’s right hand. Results. Sixty observations of thenar StO2 and ScvO2 levels were derived from 60 subjects. Mean thenar StO2 levels were 74.72 ± 11.18% and displayed significant correlation with paired ScvO2 measurements ( m = 72.17 ± 9.77%; ρ = 0.317, P = .018). Correlation was much more significant in subjects who were not on mechanical ventilatory support as opposed to those who were on it ( ρSORA = 0.496, PSORA = .003, vs ρVENT = 0.161, PVENT = .433). A thenar StO2 of 73% had a sensitivity of 80% and a specificity of 77.8% in predicting an ScvO2 of less than 65%. Conclusion. This is the first study to report correlation of thenar StO2 and ScvO2 levels in children. Our study results show a significant correlation between these levels. Thenar StO2 measurements may have a role in the bedside management of critically ill children in whom ScvO2 monitoring is not available.


Author(s):  
Marc de Moya ◽  
Leandra Krowsoski

The multicenter randomized control trial of “Lactate Clearance versus Central Oxygen Saturation as Goals of Early Sepsis Therapy” compares the standard monitoring of central venous oxygen saturation (ScvO2) recommended by the Surviving Sepsis Campaign guidelines to the clearance of lactate to determine tissue perfusion and guide resuscitation. This study suggests a protocol that uses the trend of lactate throughout the initial interventions for sepsis with a goal clearance of 10% in place of ScvO2 measured via central venous catheter. When rates of in-hospital mortality, ICU length of stay, ventilator-free days, and new-onset multiple organ failure were compared between the two groups, outcomes were non-inferior with the use of lactate clearance. The results demonstrate that lactate clearance can be used in place of ScvO2 as part of a resuscitation protocol that includes quantitative goals for CVP and MAP to yield an equivalent short-term survival outcome in early sepsis.


2009 ◽  
Vol 26 (6) ◽  
pp. 529-531
Author(s):  
Sigune Peiniger ◽  
Toni Steinbuechel ◽  
Bertil Bouillon ◽  
Frank Wappler ◽  
Samir G Sakka

2004 ◽  
Vol 30 (3) ◽  
pp. 468-471 ◽  
Author(s):  
Nicole Nagdyman ◽  
Thilo Fleck ◽  
Sven Barth ◽  
Hashim Abdul-Khaliq ◽  
Brigitte Stiller ◽  
...  

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