scholarly journals Sub-acute antihyperlipidemic and antihyperglycemic activity of the hexane extract of a polyherbal mixture in streptozotocin-induced diabetic rats

2021 ◽  
Vol 50 (3) ◽  
pp. 279
Author(s):  
S. N. T. I. Sampath ◽  
S. Jayasinghe ◽  
A. P. Attanayake ◽  
V. Karunaratne
Keyword(s):  
Diabetic Rats ◽  
Hexane Extract ◽  
Antihyperglycemic Activity

Chenopodium quinoa Exhibits Antihyperglycemic Activity in Streptozotocin-Induced Diabetic Rats

2021 ◽  
Vol 19 ◽  
Author(s):  
Amine Azzane ◽  
Ayou Amssayef ◽  
Mohame Eddouks
Keyword(s):  
Antioxidant Activity ◽  
Aqueous Extract ◽  
Histopathological Examination ◽  
Chenopodium Quinoa ◽  
Diabetic Rats ◽  
Favorable Effect ◽  
Antihyperglycemic Activity ◽  
Glucose Levels ◽  
Blood Glucose Levels

Aims: The aim of the study was to evaluate the antihyperglycemic effect of Chenopodium quinoa. Background: Chenopodium quinoa is a pseudocereal plant with several medicinal properties. Objective: The goal of this investigation was to determine the antihyperglycemic activity of Chenopodium quinoa in both normal and streptozotocin(STZ)-induced diabetic rats. Methods: In this study, the effect of the aqueous extract of Chenopodium quinoa seeds (AECQS) (60 mg/kg) on blood glucose levels was evaluated in both normal and diabetic rats after a single (6 hours) and repeated oral administration (7 days of treatment). The effect of this herb on glucose tolerance and lipid profile was also studied. Additionally, histopathological examination of liver was carried out using the Hematoxylin-Eosin method. Furthermore, the in vitro antioxidant activity as well as a preliminary phytochemical screening and quantification of some secondary metabolites (phenolic compounds, flavonoids and tannins) were performed according to standard methods. Results: AECQS produced a significant lowering effect on plasma glucose levels in STZ-induced diabetic rats. In addition, this extract exhibited a remarkable amelioration on hepatic histopathology in diabetic rats. In addition, the extract exerted a remarkable antioxidant activity which could be due to the presence of some compounds found in this herb. Conclusion: In conclusion, this study demonstrates that the aqueous extract of Chenopodium quinoa seeds has a favorable effect in controlling diabetes mellitus.

scholarly journals Preclinical evaluation of antihyperglycemic activity of Clerodendron infortunatum leaf against streptozotocin-induced diabetic rats

2011 ◽  
Vol 2 (2) ◽  
pp. 92-100 ◽  
Author(s):  
Sudipta Das ◽  
Sanjib Bhattacharya ◽  
Angelene Prasanna ◽  
R. B. Suresh Kumar ◽  
Goutam Pramanik ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Antihyperglycemic Activity ◽  
Preclinical Evaluation

scholarly journals Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Sriparna KunduSen ◽  
Pallab K. Haldar ◽  
Malaya Gupta ◽  
Upal K. Mazumder ◽  
Prerona Saha ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Biochemical Parameters ◽  
Diabetic Rats ◽  
Serum Biochemical Parameters ◽  
Fruit Peel ◽  
Antihyperglycemic Activity ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Serum Biochemical ◽  
Citrus Limetta

The present paper aims to evaluate antihyperglycemic activity of methanol extract of Citrus limetta fruit peel (MECL) in streptozotocin-induced (STZ; 65 mg/kg b.w.) diabetic rats. Three days after STZ induction, diabetic rats received MECL orally at 200 and 400 mg kg-1 body weight daily for 15 days. Glibenclamide (0.5 mg kg-1 p. o.) was used as reference drug. Blood glucose levels were measured on 0th, 4th, 8th, and 15th days of study. Serum biochemical parameters namely, SGOT, SGPT and ALP were estimated. The TBARS and GSH levels of pancreas, kidney, and liver were determined. MECL significantly (P<0.001) and dose dependently normalized blood glucose levels and serum biochemical parameters, decreased lipid peroxidation, and recovered GSH as compared to those of STZ control. The present paper infers that in STZ-induced diabetic Wistar rats, C. limetta fruit peel demonstrated a potential antihyperglycemic effect which may be attributed to its antioxidant property.

scholarly journals Comparative Study of Antidiabetic Activity of Hexane-Extract of Lemon Peel (Limon citrus) and Glimepiride in Alloxan-Induced Diabetic Rats

2012 ◽  
Vol 15 (2) ◽  
pp. 131-134 ◽  
Author(s):  
Mohammad Naim ◽  
Farhad Mohammad Amjad ◽  
Sania Sultana ◽  
Sheikh Nazrul Islam ◽  
Muhammad Amjad Hossain ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Metabolic Disorder ◽  
Elevated Level ◽  
Pharmaceutical Journal ◽  
Diabetic Rats ◽  
Hexane Extract ◽  
Antidiabetic Activity ◽  
Citrus Limon ◽  
Lemon Peel

Diabetes is classified as a metabolic disorder manifested by elevated level of glucose in the blood. An attempt has been made to compare the antidiabetic activity of hexane extract of lemon peel (Citrus Limon) with that of a marketed product, glimepiride, in alloxan-induced diabetic rats. The study was performed by the measurement of blood glucose level using a glucometer. It was found that the hexane extract of lemon peel showed antidiabetic activity comparable to that of glimepiride. It can thus be inferred that the extract of lemon peel possesses significant antidiabetic activity. DOI: http://dx.doi.org/10.3329/bpj.v15i2.12577 Bangladesh Pharmaceutical Journal 15(2): 131-134, 2012

Evaluation of antihyperglycemic activity of Cocos nucifera Linn. on streptozotocin induced type 2 diabetic rats

2011 ◽  
Vol 138 (3) ◽  
pp. 769-773 ◽  
Author(s):  
Sagar Naskar ◽  
Upal K. Mazumder ◽  
Goutam Pramanik ◽  
Malaya Gupta ◽  
R.B. Suresh Kumar ◽  
...  
Keyword(s):  
Cocos Nucifera ◽  
Diabetic Rats ◽  
Antihyperglycemic Activity ◽  
Type 2 Diabetic

scholarly journals Antihyperglycemic activity of Caralluma quadrangula in streptozotocin-induced diabetic rats

2017 ◽  
Vol 55 (2) ◽  
pp. 269-272 ◽  
Author(s):  
Essam Abdel-Sattar ◽  
Shohda A. EL-Maraghy ◽  
Riham Salah El-Dine ◽  
Sherine M. Rizk
Keyword(s):  
Diabetic Rats ◽  
Antihyperglycemic Activity
Sign in / Sign up

Export Citation Format

Share Document