Critical Role of IRF-8 in Negative Regulation of TLR3 Expression by Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2 Activity in Human Myeloid Dendritic Cells

Alessandra Fragale; Emilia Stellacci; Ramona Ilari; Anna Lisa Remoli; Angela Lanciotti; Edvige Perrotti; Iart Shytaj; Roberto Orsatti; Harshani R. Lawrence; Nicholas J. Lawrence; Jerry Wu; Michael Rehli; Keiko Ozato; Angela Battistini

doi:10.4049/jimmunol.1000918

Critical Role of IRF-8 in Negative Regulation of TLR3 Expression by Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2 Activity in Human Myeloid Dendritic Cells

The Journal of Immunology ◽

10.4049/jimmunol.1000918 ◽

2011 ◽

Vol 186 (4) ◽

pp. 1951-1962 ◽

Cited By ~ 24

Author(s):

Alessandra Fragale ◽

Emilia Stellacci ◽

Ramona Ilari ◽

Anna Lisa Remoli ◽

Angela Lanciotti ◽

...

Keyword(s):

Dendritic Cells ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Critical Role ◽

Negative Regulation ◽

Myeloid Dendritic Cells ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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Negative Regulation of Monocyte Adhesion to Arterial Elastic Laminae by Signal Regulatory Protein α and Src Homology 2 Domain-containing Protein-Tyrosine Phosphatase-1

Journal of Biological Chemistry ◽

10.1074/jbc.m503866200 ◽

2005 ◽

Vol 280 (47) ◽

pp. 39294-39301 ◽

Cited By ~ 24

Author(s):

Shu Q. Liu ◽

Paul K. Alkema ◽

Christopher Tieché ◽

Brandon J. Tefft ◽

Diana Z. Liu ◽

...

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Regulatory Protein ◽

Negative Regulation ◽

Monocyte Adhesion ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain ◽

Elastic Laminae

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Resistance to Experimental Autoimmune Encephalomyelitis and Impaired T Cell Priming by Dendritic Cells in Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 Mutant Mice

The Journal of Immunology ◽

10.4049/jimmunol.179.2.869 ◽

2007 ◽

Vol 179 (2) ◽

pp. 869-877 ◽

Cited By ~ 41

Author(s):

Takeshi Tomizawa ◽

Yuka Kaneko ◽

Yoriaki Kaneko ◽

Yasuyuki Saito ◽

Hiroshi Ohnishi ◽

...

Keyword(s):

Dendritic Cells ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Autoimmune Encephalomyelitis ◽

Src Homology 2 ◽

Src Homology ◽

T Cell Priming ◽

Src Homology 2 Domain ◽

Phosphatase Substrate ◽

Experimental Autoimmune

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Mutational Analysis of the Mechanism of Negative Regulation by Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 of Phagocytosis in Macrophages

The Journal of Immunology ◽

10.4049/jimmunol.177.5.3123 ◽

2006 ◽

Vol 177 (5) ◽

pp. 3123-3132 ◽

Cited By ~ 9

Author(s):

Hiroshi Ikeda ◽

Hideki Okazawa ◽

Hiroshi Ohnishi ◽

Yoji Murata ◽

Per-Arne Oldenborg ◽

...

Keyword(s):

Protein Tyrosine Phosphatase ◽

Mutational Analysis ◽

Tyrosine Phosphatase ◽

Negative Regulation ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain ◽

Phosphatase Substrate

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Investigating the reason for loss-of-function of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) caused by Y279C mutation through molecular dynamics simulation

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2019.1634641 ◽

2019 ◽

Vol 38 (9) ◽

pp. 2509-2520 ◽

Cited By ~ 2

Author(s):

Wen-Shan Liu ◽

Rui-Rui Wang ◽

Wei-Ya Li ◽

Mei Rong ◽

Chi-Lu Liu ◽

...

Keyword(s):

Molecular Dynamics ◽

Molecular Dynamics Simulation ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Dynamics Simulation ◽

Loss Of Function ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.105384 ◽

2021 ◽

pp. 105384

Author(s):

Xiang-Dong Meng ◽

Li-Xin Gao ◽

Zhi-Jia Wang ◽

Bo Feng ◽

Chun Zhang ◽

...

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Biological Evaluation ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Oxadiazole Derivatives ◽

Src Homology 2 Domain ◽

Synthesis And Biological Evaluation

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Inhibition of Src homology 2 domain containing protein tyrosine phosphatase as the possible mechanism of metformin-assisted amelioration of obesity induced insulin resistance in high fat diet fed C57BL/6J mice

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2017.04.012 ◽

2017 ◽

Vol 487 (1) ◽

pp. 54-61 ◽

Cited By ~ 5

Author(s):

Yadhu Sharma ◽

Samina Bashir ◽

Ansarullah ◽

Mohemmed Faraz Khan ◽

Altaf Ahmad ◽

...

Keyword(s):

Insulin Resistance ◽

Protein Tyrosine Phosphatase ◽

High Fat Diet ◽

Tyrosine Phosphatase ◽

High Fat ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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Design, synthesis, biological evaluation, common feature pharmacophore model and molecular dynamics simulation studies of ethyl 4-(phenoxymethyl)-2-phenylthiazole-5-carboxylate as Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2020.1726817 ◽

2020 ◽

pp. 1-15 ◽

Cited By ~ 3

Author(s):

Jingwei Wu ◽

Weiya Li ◽

Zhihui Zheng ◽

Xinhua Lu ◽

Huan Zhang ◽

...

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Pharmacophore Model ◽

Biological Evaluation ◽

Dynamics Simulation ◽

Simulation Studies ◽

Design Synthesis ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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Chicken Ig-Like Receptor B2, a Member of a Multigene Family, Is Mainly Expressed on B Lymphocytes, Recruits Both Src Homology 2 Domain Containing Protein Tyrosine Phosphatase (SHP)-1 and SHP-2, and Inhibits Proliferation

The Journal of Immunology ◽

10.4049/jimmunol.173.12.7385 ◽

2004 ◽

Vol 173 (12) ◽

pp. 7385-7393 ◽

Cited By ~ 29

Author(s):

Birgit C. Viertlboeck ◽

Richard P. M. A. Crooijmans ◽

Martien A. M. Groenen ◽

Thomas W. F. Göbel

Keyword(s):

B Lymphocytes ◽

Protein Tyrosine Phosphatase ◽

Multigene Family ◽

Tyrosine Phosphatase ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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Cell surface expression of channel catfish leukocyte immune-type receptors (IpLITRs) and recruitment of both Src homology 2 domain-containing protein tyrosine phosphatase (SHP)-1 and SHP-2

Developmental & Comparative Immunology ◽

10.1016/j.dci.2008.10.006 ◽

2009 ◽

Vol 33 (4) ◽

pp. 570-582 ◽

Cited By ~ 19

Author(s):

Benjamin C.S. Montgomery ◽

Jacqueline Mewes ◽

Chelsea Davidson ◽

Deborah N. Burshtyn ◽

James L. Stafford

Keyword(s):

Cell Surface ◽

Channel Catfish ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Surface Expression ◽

Cell Surface Expression ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds

Journal of Medicinal Chemistry ◽

10.1021/jm8002526 ◽

2008 ◽

Vol 51 (16) ◽

pp. 4948-4956 ◽

Cited By ~ 55

Author(s):

Harshani R. Lawrence ◽

Roberta Pireddu ◽

Liwei Chen ◽

Yunting Luo ◽

Shen-Shu Sung ◽

...

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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