scholarly journals Differentiated Thyroid Cancer with Extrathyroidal Extension: Prognosis and the Role of External Beam Radiotherapy

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Michael A. Sia ◽  
Richard W. Tsang ◽  
Tony Panzarella ◽  
James D. Brierley
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Residual Disease ◽  
External Beam Radiotherapy ◽  
Local Relapse ◽  
Extrathyroidal Extension ◽  
External Beam ◽  
Locoregional Failure ◽  
Cause Specific Survival

A study was performed to identify variables that affected cause-specific survival (CSS) and local relapse-free rate (LRFR) in patients with differentiated thyroid cancer (DTC) and extrathyroid extension (ETE) and to examine the role of external beam radiotherapy (XRT). Prognostic factors were similar to those found in studies of all patients with DTC. In patients with postoperative gross residual disease treated with radiotherapy, 10-year CSS and LRFR were 48% and 90%. For patients with no residual or microscopic disease, 10-year CSS and LRFR were 92% and 93%. In patients older than 60 years with T3 ETE but no gross residual disease postoperatively there was an improved LRFR at 5 years of 96%, compared to 87.5% without XRT (P=.02). Patients with gross ETE benefit from XRT and there may be a potential benefit in reducing locoregional failure in patients over 60 years with minimal extrathyroidal extension (T3).

The role of external beam radiotherapy in the management of differentiated thyroid cancer

2000 ◽  
Vol 54 (6) ◽  
pp. 345-349 ◽  
Author(s):  
R. Mazzarotto ◽  
M.G. Cesaro ◽  
O. Lora ◽  
D. Rubello ◽  
D. Casara ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
External Beam Radiotherapy ◽  
External Beam

scholarly journals Role of Radiotherapy in Differentiated Thyroid Cancer

2013 ◽  
Vol 5 (3) ◽  
pp. 71-75
Author(s):  
Punita Lal ◽  
Prakash Kumar Swain
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Residual Disease ◽  
External Beam Radiotherapy ◽  
Hormone Replacement ◽  
Palliative Radiotherapy ◽  
Target Volume ◽  
Lymph Node Involvement ◽  
Adjuvant Setting

ABSTRACT Differentiated thyroid cancers (i.e. papillary or follicular) account for majority of thyroid malignancies. Even though surgery has been the mainstay for these tumors, use of radioactive iodine (I131) therapy and thyroid hormone replacement therapy is common in most of these tumors in adjuvant setting. Radiotherapy is indicated in the presence of, gross residual disease after surgery, extra-capsular extension, and extensive lymph node involvement. As thyroid gland is located at the root of neck, sometimes with retrosternal extension and surrounded by critical structures, it is difficult to adequately cover the entire target volume with conventional radiotherapy technique. IMRT is a useful technique in these tumors, since it provides good dose distribution along with sparing of spinal cord while treating thyroid bed in adjuvant setting, and therefore it needs to be further standardized. Additionally palliative radiotherapy is effective in brain and bone metastasis. To conclude, external beam radiotherapy is an established and effective mode of therapy both in curative and palliative settings. How to cite this article Lal P, Swain PK. Role of Radiotherapy in Differentiated Thyroid Cancer. World J Endoc Surg 2013;5(3): 71-75.

scholarly journals Role of adjuvant postoperative external beam radiotherapy for well differentiated thyroid cancer

2013 ◽  
Vol 31 (3) ◽  
pp. 162 ◽  
Author(s):  
Jeanny Kwon ◽  
Hong-Gyun Wu ◽  
Yeo-Kyu Youn ◽  
Kyu Eun Lee ◽  
Kwang Hyun Kim ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
External Beam Radiotherapy ◽  
External Beam ◽  
Well Differentiated

scholarly journals Postoperative external beam radiotherapy for locoregional control in iodine refractory differentiated thyroid cancer

2021 ◽  
Author(s):  
Andries H. Groen ◽  
Deborah van Dijk ◽  
Wim Sluiter ◽  
Thera P Links ◽  
Hendrik P. Bijl ◽  
...  
Keyword(s):  
Overall Survival ◽  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Residual Disease ◽  
External Beam Radiotherapy ◽  
Locally Advanced ◽  
Locoregional Control ◽  
External Beam ◽  
Initial Surgery ◽  
Repeated Surgery

Background: The role of postoperative external beam radiotherapy (EBRT) in patients with residual iodine refractory differentiated thyroid cancer (IR-DTC) is still inconclusive. The aim of this retrospective study was to evaluate locoregional control (LRC) and overall survival (OS), and potential side effects after postoperative EBRT for both microscopic and macroscopic non-radically resected locally advanced IR-DTC. Methods: Between 1990 and 2016, 49 patients with locally advanced IR-DTC received EBRT for microscopic (R1; n=28) or macroscopic (R2; n=21) locoregional residual disease. For more insight into the added effect of EBRT we performed an intra-patient sub-analysis in 32 patients who had undergone more than one surgical intervention, comparing LRC after primary, curative-intended surgery with LRC after repeated surgery plus EBRT. To estimate LRC and OS we used Kaplan Meier curves. From 2007 onwards, we prospectively recorded toxicity data in our head and neck cancer database (n=10). Results: LRC rates five years after EBRT were higher for R1 (84.3%) than for R2 (44.9%) residual disease (p=0.016). The five-year OS rate after EBRT was 72.1% for R1 and 33.1% for R2 disease (p=0.003). In the intra-patient analysis (n=32) LRC rates were 6.3% five years after only initial surgery, and 77.9% after repeated surgery with EBRT (p=<0.001). Acute toxicity was limited to grade I and II xerostomia, mucositis, and hoarseness; only one patient developed late grade III dysphagia. Conclusions: Postoperative EBRT is associated with long-lasting locoregional control and overall survival with acceptable toxicity in patients with locally advanced IR-DTC, especially in microscopic residual disease.

scholarly journals Adjuvant External Beam Radiotherapy in Locally Advanced Differentiated Thyroid Cancer

2017 ◽  
Vol 143 (12) ◽  
pp. 1244 ◽  
Author(s):  
Samantha Tam ◽  
Moran Amit ◽  
Mongkol Boonsripitayanon ◽  
Maria E. Cabanillas ◽  
Naifa L. Busaidy ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
External Beam Radiotherapy ◽  
Locally Advanced ◽  
External Beam

External Beam Radiotherapy for Differentiated Thyroid Cancer

2010 ◽  
Vol 22 (6) ◽  
pp. 456-463 ◽  
Author(s):  
C. Powell ◽  
K. Newbold ◽  
K.J. Harrington ◽  
S.A. Bhide ◽  
C.M. Nutting
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
External Beam Radiotherapy ◽  
External Beam
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