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2022 ◽  
pp. 726-741
Author(s):  
Abdullah Essam Kattan ◽  
Aws Abdulrahman Alsuhaibani ◽  
Abdullah Alsuhaibani ◽  
Tareq Salah Hassan

Treatment of keloids is usually challenging, requiring a multimodal approach with no universally accepted treatment modality among the wide range of alternative keloid treatments. Excision of keloid lesion usually eliminates symptoms and it is the main treatment with considerable recurrence rate. Recurrence rate ranges from 45-100% when surgical excision is performed as monotherapy. Furthermore, Recurrent Keloids have a higher recurrence rate after surgery. In this case we discuss a challenging case of young female presented with third recurrence in lobule of the ear with defect necessitated flap reconstruction with concern for possible damage by the flap if radiation was given as external beam postoperatively. Intraoperative electron beam therapy was utilized with high safety and efficacy. To our knowledge this is the first case in the Middle East to use this technique in treating Keloid. Conclusion Treatment of keloids is usually challenging, requiring a multimodal approach. Excision of keloid lesion usually eliminates symptoms and it is the main treatment with considerable recurrence rate .Recurrence rate ranges from 45-100% when surgical excision is performed as monotherapy. Furthermore, Recurrent Keloids have a higher recurrence rate after surgery. Radiation is a valid option for decreasing risk of recurrence in recurrent keloid with high safety and efficacy profile. In this case we discuss a challenging case of young female presented with third recurrence in lobule of the ear with defect necessitated flap reconstruction with concern for possible damage by the flap if radiation was given as external beam postoperatively. Intraoperative electron beam therapy was utilized with high safety and efficacy. To our knowledge this is the first case in the Middle East to use this technique in treating Keloid. Keywords: Keloid; Radiation; Intraoperative Radiation; IOeRT


Oral Oncology ◽  
2022 ◽  
Vol 125 ◽  
pp. 105715
Author(s):  
Charlotte Le Roy ◽  
Cécile Le Péchoux ◽  
Claire Alapetite ◽  
Ratislav Bahleda ◽  
Carine Ngo ◽  
...  

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Hideya Yamazaki ◽  
Gen Suzuki ◽  
Norihiro Aibe ◽  
Daisuke Shimizu ◽  
Takuya Kimoto ◽  
...  

AbstractAs several recent researches focus on the importance of Gleason 9–10, we examine the role of radiotherapy dose escalation in those patients. We analyzed 476 patients with Gleason score 9–10 prostate cancer treated with radiotherapy. Of them, 127 patients were treated with conventional-dose external beam radiotherapy (Conv RT) and 349 patients were treated with high-dose radiotherapy (HDRT; 249 patients received high-dose-rate brachytherapy boost + external beam radiotherapy [HDR boost] and 100 patients received intensity-modulated radiotherapy [IMRT]). We compared these treatment groups using multi-institutional retrospective data. The patients had a median follow-up period of 66.3 months. HDRT showed superior biochemical disease-free survival (bDFS) rate (85.2%; HDR boost 84.7% and IMRT 86.6%) to Conv RT (71.1%, p < 0.0001) at 5 years, with a hazard ratio of 0.448. There were borderline difference in prostate cancer-specific mortality (PCSM; 4.3% and 2.75%, p = 0.0581), and distant metastasis-free survival (DMFS; 94.4% and 89.6%, p = 0.0916) rates at 5-years between Conv RT and HDRT group. Dose escalated radiotherapy showed better bDFS, borderline improvement in PCSM, and equivocal outcome in DMFS in with clinically localized Gleason 9–10 prostate cancer.


2022 ◽  
Vol 23 (1) ◽  
pp. 23-25
Author(s):  
Alfonso Gomez-Iturriaga ◽  
Mira Keyes ◽  
Jarad Martin ◽  
Daniel E Spratt

Author(s):  
Christopher Leigh Hallemeier ◽  
Smith Apisarnthanarax ◽  
Laura Ann Dawson

2021 ◽  
Vol 42 (1) ◽  
pp. 93-96
Author(s):  
MUTLAY SAYAN ◽  
IRINA VERGALASOVA ◽  
IMRAAN JAN ◽  
SHICHA KUMAR ◽  
NANCY CHAN ◽  
...  

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