scholarly journals Kimura Disease: A Case Report and Review of the Literature with A New Management Protocol

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Mohamed Ashraf Fouda ◽  
Osama Gheith ◽  
Ayman Refaie ◽  
Mohamed El-Saeed ◽  
Adel Bakr ◽  
...  

Kimura disease (KD) is a chronic inflammatory disorder with angiolymphatic proliferation, usually affecting young men of Asian race but is rare in other races. The etiology of KD is still unknown. It is often accompanied by nephrotic syndrome. Herein, we present an atypical manifestation of Kimura disease occurring in a Caucasian man with steroid-responsive early membranous glomerulonephritis. Kimura disease can present atypically in a middle-aged Caucasian man with secondary steroid-responsive nephrotic syndrome. Steroid, endoxan, and MMF can be used safely and successfully in such situation. The diagnosis of KD can be difficult and misleading, and patients with this disease are often evaluated using avoidable procedures by just not being aware of KD.

2021 ◽  
pp. 116-123
Author(s):  
Roald Vissing-Uhre ◽  
Alastair Hansen ◽  
Susanne Frevert ◽  
Ditte Hansen

Kimura disease (KD) is a chronic, inflammatory disorder with slowly developing subcutaneous tumor-like swellings, often occurring in the head and neck region. KD is diagnosed based on histology, elevated levels of immunoglobulin type E, and increased peripheral eosinophil granulocytes. KD may coexist with glomerular renal diseases, and this case report is based on a patient with KD-associated membranous nephropathy. Patients with membranous nephropathy without KD have demonstrated responsiveness to treatment with monoclonal anti-CD20 antibodies. This case report is the first to investigate the effect of rituximab treatment in a patient with KD-associated membranous nephropathy. A 30-year-old Italian man living in Denmark was diagnosed with Kimura’s disease based on subcutaneous nodules with eosinophil angiolymphoid hyperplasia. The patient was admitted to the hospital due to nephrotic syndrome. Serology showed eosinophil granulocytosis and negative PLA2-receptor antibody. Renal biopsy showed membranous nephropathy, and the patient was treated with systemic methylprednisolone followed by cyclosporin and then cyclophosphamide with only partial remission. Ultimately, treatment with intravenous rituximab was initiated, which resulted in overall remission and no nephrotic relapses at 30 months of follow-up. Thus, intravenous rituximab effectively decreased proteinuria and prevented nephrotic relapses in a patient with treatment-refractory membranous nephropathy due to KD.


Author(s):  
Harshi Dhingra ◽  
Ruchi Nagpal ◽  
Asif Baliyan ◽  
Sathyavathi R Alva

Kimura disease is a rare chronic inflammatory disorder of unknown cause, primarily seen in young Asian males. The disease is characterized by painless subcutaneous swelling, blood and tissue eosinophilia and raised IgE levels. Early diagnosis of Kimura’s disease may spare the patient from unnecessary invasive diagnostic procedure. We describe a case of Kimura disease in a 14-year old male presenting with left submandibular swelling and also provide a brief review of the literature. 


Author(s):  
Ankur Batra ◽  
Megha Goyal ◽  
Sachin Goel ◽  
Lakshmi Vaid

<p>Kimura’s disease (KD) is a chronic inflammatory disorder with angiolymphatic proliferation of unknown etiology, usually affecting young men of Asian race but is rare in other races. Affected Indians are very rare. Herein, we present an atypical manifestation of Kimura’s disease occurring in an Indian male who presented with bilateral postaural lymphadenopathy. The diagnosis of Kimura’s disease can be very difficult and misleading; it is important not to ignore histopathological features.</p>


Author(s):  
Eric Holmgren ◽  
Derrek Schartz ◽  
Nithya Puttige Ramesh ◽  
Kimutai Sylvester ◽  
Clifford Eskey

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
L. Padmavathy ◽  
L. Lakshmana Rao ◽  
M. Dhana Lakshmi ◽  
N. Sylvester ◽  
N. Ethirajan

Lichen sclerosus (LS) is a chronic inflammatory disorder of an unknown aetiology most commonly affecting the anogenital area. However, extragenital involvement also occurs uncommonly. A case of extra-genital LS involving the areolae of both breasts, in a 15-year-old boy, is reported for its rarity.


2017 ◽  
Vol 24 (1) ◽  
pp. 64-66 ◽  
Author(s):  
Hasnur Zaman Hashim ◽  
Fan Kee Hoo ◽  
Sazlyna Mohd Sazlly Lim ◽  
Mohd Hazmi Mohamed ◽  
Vasudevan Ramachandran ◽  
...  

2017 ◽  
Vol 25 (1) ◽  
pp. 59-61 ◽  
Author(s):  
Suman Kumar Das ◽  
Mukesh Kumar Singh ◽  
Indranath Kundu ◽  
Swapan Kumar Ghosh

Introduction Kimura’s Disease is a chronic inflammatory disorder of lymph node which is very rare in Indian population. Case Report A 15 year old boy with multiple postauricular swelling for 18 months presenting in OPD and diagnosed having eosinophilia. Then excision biopsy was taken, which indicates Kimura’s Disease. Patient was treated with high dose of corticosteroid. Conclusion Kimura’s disease, though rare should be kept in mind for treating a patient with lymphadenopathy with eosinophilia or high IgE level, because it can spare the patient unnecessary invasive procedure.


1994 ◽  
Vol 8 (3) ◽  
pp. 290-294 ◽  
Author(s):  
Laszlo Hopp ◽  
Nisan Gilboa ◽  
Geoffrey Kurland ◽  
Nancy Weichler ◽  
Trevor J. Orchard

Sign in / Sign up

Export Citation Format

Share Document