scholarly journals KIMURA DISEASE : CASE REPORT AND BRIEF REVIEW OF LITERATURE

2018 ◽  
Author(s):  
Harshi Dhingra ◽  
Ruchi Nagpal ◽  
Asif Baliyan ◽  
Sathyavathi R Alva
Keyword(s):  
Diagnostic Procedure ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Review Of Literature ◽  
Review Of The Literature ◽  
Kimura Disease ◽  
Chronic Inflammatory Disorder ◽  
Tissue Eosinophilia ◽  
Disease Case ◽  
Invasive Diagnostic Procedure

Kimura disease is a rare chronic inflammatory disorder of unknown cause, primarily seen in young Asian males. The disease is characterized by painless subcutaneous swelling, blood and tissue eosinophilia and raised IgE levels. Early diagnosis of Kimura’s disease may spare the patient from unnecessary invasive diagnostic procedure. We describe a case of Kimura disease in a 14-year old male presenting with left submandibular swelling and also provide a brief review of the literature. 

scholarly journals Rituximab Treatment in a Patient with Kimura Disease and Membranous Nephropathy: Case Report

2021 ◽  
pp. 116-123
Author(s):  
Roald Vissing-Uhre ◽  
Alastair Hansen ◽  
Susanne Frevert ◽  
Ditte Hansen
Keyword(s):  
Case Report ◽  
Membranous Nephropathy ◽  
Neck Region ◽  
Renal Diseases ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Kimura Disease ◽  
Chronic Inflammatory Disorder ◽  
Eosinophil Granulocytes ◽  
Anti Cd20

Kimura disease (KD) is a chronic, inflammatory disorder with slowly developing subcutaneous tumor-like swellings, often occurring in the head and neck region. KD is diagnosed based on histology, elevated levels of immunoglobulin type E, and increased peripheral eosinophil granulocytes. KD may coexist with glomerular renal diseases, and this case report is based on a patient with KD-associated membranous nephropathy. Patients with membranous nephropathy without KD have demonstrated responsiveness to treatment with monoclonal anti-CD20 antibodies. This case report is the first to investigate the effect of rituximab treatment in a patient with KD-associated membranous nephropathy. A 30-year-old Italian man living in Denmark was diagnosed with Kimura’s disease based on subcutaneous nodules with eosinophil angiolymphoid hyperplasia. The patient was admitted to the hospital due to nephrotic syndrome. Serology showed eosinophil granulocytosis and negative PLA2-receptor antibody. Renal biopsy showed membranous nephropathy, and the patient was treated with systemic methylprednisolone followed by cyclosporin and then cyclophosphamide with only partial remission. Ultimately, treatment with intravenous rituximab was initiated, which resulted in overall remission and no nephrotic relapses at 30 months of follow-up. Thus, intravenous rituximab effectively decreased proteinuria and prevented nephrotic relapses in a patient with treatment-refractory membranous nephropathy due to KD.

scholarly journals Kimura Disease: A Case Report and Review of the Literature with A New Management Protocol

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Mohamed Ashraf Fouda ◽  
Osama Gheith ◽  
Ayman Refaie ◽  
Mohamed El-Saeed ◽  
Adel Bakr ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Case Report ◽  
Membranous Glomerulonephritis ◽  
Inflammatory Disorder ◽  
Review Of The Literature ◽  
Kimura Disease ◽  
Chronic Inflammatory Disorder ◽  
Asian Race ◽  
Management Protocol ◽  
Atypical Manifestation

Kimura disease (KD) is a chronic inflammatory disorder with angiolymphatic proliferation, usually affecting young men of Asian race but is rare in other races. The etiology of KD is still unknown. It is often accompanied by nephrotic syndrome. Herein, we present an atypical manifestation of Kimura disease occurring in a Caucasian man with steroid-responsive early membranous glomerulonephritis. Kimura disease can present atypically in a middle-aged Caucasian man with secondary steroid-responsive nephrotic syndrome. Steroid, endoxan, and MMF can be used safely and successfully in such situation. The diagnosis of KD can be difficult and misleading, and patients with this disease are often evaluated using avoidable procedures by just not being aware of KD.

scholarly journals Case report with review of literature for the dilemma of diagnosis of CLIPPERS

2019 ◽  
Vol 14 (3) ◽  
pp. FNL22
Author(s):  
Shadi M Ramadan ◽  
Abdulaziz Al-Ghamdi ◽  
A Idris Saleh ◽  
Rabia Muddassir ◽  
Sayed S Rahman ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Brain Biopsy ◽  
Initial Response ◽  
Inflammatory Disorder ◽  
Imaging Features ◽  
Review Of Literature ◽  
Review Of The Literature ◽  
Radiological Findings ◽  
Gadolinium Enhancement ◽  
Chronic Inflammatory Disorder

CLIPPER is a chronic inflammatory disorder in the CNS, which is characterized by MRI appearance of punctate and curvilinear gadolinium enhancement that involve the pons and the cerebellum and exquisite response to steroid. We report a patient presented with clinical and radiological features suggestive of CLIPPERS. However, despite the initial response to steroid, there were dramatic changes in the course of his disease that were conducive to considering another diagnosis. We searched PubMed using word (CLIPPERS) till December 2018. The pathogenesis, clinical manifestations, imaging features, treatment and prognosis of this disorder are summarized. A review of the literature for cases of CLIPPERS demonstrated a subset of patients who later discovered to have an alternative pathology. Indeed, clinicians should be scrupulous to diagnose this disease based solely on the clinical and radiological findings and they should have a lower threshold of having a brain biopsy.

scholarly journals Kimura’s disease as an uncommon cause of post auricular swelling

2020 ◽  
Vol 6 (9) ◽  
pp. 1737
Author(s):  
Chandre Gowda Bendiganahalli Venkate Gowda ◽  
Madhuri Gandham
Keyword(s):  
Immunoglobulin E ◽  
Neck Region ◽  
Unknown Etiology ◽  
Kimura’S Disease ◽  
Histopathological Diagnosis ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Tissue Eosinophilia ◽  
Common Causes ◽  
Rule Out

<p>Kimura’s disease (KD) is a rare chronic inflammatory disorder of unknown etiology, primarily seen in young Asian males. In India, only 200 cases have been reported worldwide since its histopathological diagnosis. The disease is characterized by painless subcutaneous swelling in head &amp; neck region, blood and tissue eosinophilia and raised Immunoglobulin E (IgE) levels. A systematic multidisciplinary approach is mandatory to rule out the other common causes of post auricular lymphadenopathy. The diagnosis of KD can be difficult and misleading and patients with this disease are often evaluated using avoidable procedures by just not being aware of KD. Here, we present a case of a 20 year old male who presented with nodular swellings in the bilateral post auricular region. The diagnosis of KD was done based on characteristic histopathologic finding in conjunction with peripheral eosinophilia.</p>

scholarly journals Kimura’s disease: a diagnostic and therapeutic enigma

2018 ◽  
Vol 6 (6) ◽  
pp. 2176
Author(s):  
Vinay Bharat ◽  
Abhishek Gupta ◽  
Rani Bansal ◽  
Priya Gupta ◽  
Mamta Gupta
Keyword(s):  
Lymph Nodes ◽  
Elevated Serum ◽  
Neck Region ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Neck Swelling ◽  
Peripheral Eosinophilia ◽  
Head And Neck Region ◽  
Chronic Inflammatory Disorder ◽  
Reactive Hyperplasia

Kimura’s disease is a rare chronic inflammatory disorder present in 2nd and 3rd decade. It has a predilection for head and neck region presenting as a slowly growing painless swelling. It is usually accompanied by peripheral eosinophilia and elevated serum IgE and hence it was initially thought to be of allergic origin. Histologically the lesions are characterized by reactive hyperplasia of lymph nodes, eosinophilic infiltration and increase in postcapillary venules. Authors have reported a male patient with a slowly growing right sided neck swelling which is recurring even after course of steroids and excision done twice at an interval of 6 months. Kimura’s disease although a benign Lymphoid disorder but the incidence of recurrence despite taking treatment is a cause of much concern for the patient.

Eosinophilic chronic rhinosinusitis and concurrent Kimura’s disease treated with mepolizumab

2021 ◽  
Vol 14 (1) ◽  
pp. e232627
Author(s):  
Jacqueline Ho ◽  
Sophie Walter ◽  
Richard J Harvey
Keyword(s):  
English Language ◽  
Cervical Lymphadenopathy ◽  
Upper Airway ◽  
Neck Region ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Head And Neck Region ◽  
Chronic Inflammatory Disorder ◽  
First Case ◽  
Eosinophilic Chronic Rhinosinusitis

Kimura’s disease is a rare, benign, chronic inflammatory disorder characterised by its eosinophilic infiltrate. Patients often present with one or more progressively enlarging subcutaneous lymph nodes in the head and neck region or enlarging salivary glands. We describe the case of a 26-year-old man presenting with severe peripheral eosinophilia and upper airway inflammatory symptoms, who later developed cervical lymphadenopathy and formally diagnosed with Kimura’s disease. Based on our English-language MEDLINE literature search, to our knowledge this is the first case report describing treatment of Kimura’s disease with mepolizumab.

scholarly journals Kimura's Disease: A Rare Cause of Postauricular Swelling

2017 ◽  
Vol 25 (1) ◽  
pp. 59-61 ◽  
Author(s):  
Suman Kumar Das ◽  
Mukesh Kumar Singh ◽  
Indranath Kundu ◽  
Swapan Kumar Ghosh
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Indian Population ◽  
Disease Patient ◽  
Invasive Procedure ◽  
Excision Biopsy ◽  
High Dose ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder

Introduction Kimura’s Disease is a chronic inflammatory disorder of lymph node which is very rare in Indian population. Case Report A 15 year old boy with multiple postauricular swelling for 18 months presenting in OPD and diagnosed having eosinophilia. Then excision biopsy was taken, which indicates Kimura’s Disease. Patient was treated with high dose of corticosteroid. Conclusion Kimura’s disease, though rare should be kept in mind for treating a patient with lymphadenopathy with eosinophilia or high IgE level, because it can spare the patient unnecessary invasive procedure.

scholarly journals Kimura’s disease: a rare cause of facial mass in a caucasian male patient

2020 ◽  
Vol 6 (4) ◽  
pp. 20200099
Author(s):  
Célia Peixoto Sousa ◽  
Elsa Fonseca ◽  
Bárbara Viamonte ◽  
João Calheiros Lobo ◽  
António Madureira
Keyword(s):  
Immunoglobulin E ◽  
Neck Region ◽  
High Serum ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Peripheral Eosinophilia ◽  
Review Of The Literature ◽  
Head And Neck Region ◽  
Caucasian Male ◽  
Subcutaneous Mass

Kimura’s disease is an uncommon inflammatory disorder of unclear aetiology, mainly affecting young Asian descent males among their second and fourth decades of life. The disease typically emerges as a long-standing and painless subcutaneous mass lesion in the head and neck region, frequently associated with swelling of major salivary glands, particularly the parotid gland, and regional lymphadenopathy. Peripheral eosinophilia and high serum immunoglobulin E are also characteristic findings. We report a case and describe the imaging and pathological features of the disease in a 19-year-old Caucasian male, with review of the literature.

Recurrent Kimura’s disease of head and neck treated with intensity-modulated radiotherapy

2021 ◽  
Vol 14 (3) ◽  
pp. e239064
Author(s):  
Jeyaanth Venkatasai ◽  
Arvind Sathyamurthy ◽  
Jeba Karunya Ramireddy ◽  
Thomas Samuel Ram
Keyword(s):  
Intensity Modulated Radiotherapy ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Unknown Aetiology ◽  
Chronic Inflammatory Disorder ◽  
Intensity Modulated ◽  
Integrated Boost ◽  
Good Local Control ◽  
Primary Modality

Kimura’s disease (KD) is a rare, chronic inflammatory disorder of unknown aetiology, which commonly affects men of the Asian race. Here, we present a case capsule of a 39- year-old man with KD of the left cheek, managed initially by surgery alone. He developed local recurrence after 6 months and was treated with steroids and isotretinoin. Eventually, steroids were discontinued due to toxicity and the lesion progressively increased in size. The patient was successfully treated using intensity-modulated radiotherapy with simultaneous integrated boost as a primary modality with minimal adverse effects. The patient has good local control and cosmetic outcome with no radiation-related toxicity at a follow-up period of 28 months.

Kimura's disease: case report and brief review of the literature

1994 ◽  
Vol 108 (11) ◽  
pp. 1005-1007 ◽  
Author(s):  
Mette Nyrop
Keyword(s):  
Neck Region ◽  
Malignant Tumour ◽  
Chronic Inflammatory Disease ◽  
Surgical Removal ◽  
Kimura’S Disease ◽  
Review Of The Literature ◽  
Fine Needle Aspirate ◽  
Japanese People ◽  
Head And Neck Region ◽  
Disease Case

AbstractKimura's disease is a chronic inflammatory disease which often presents as a tumour-like swelling in the head and neck region with or without lymphadenopathy. Most cases have been described predominantly in Chinese and Japanese people. The lesion is benign, but it may easily be mistaken for a malignant tumour. Kimura's disease has been confused with angiolymphoid hyperplasia with eosinophilia (ALHE), from which it probably should be distinguished as a separate entity. The diagnosis may be suggested by a fine needle aspirate, but is established by a biopsy. The treatment of choice is surgical removal.A case of Kimura's disease in a Caucasian male of 12 years' duration is presented together with a brief review of the literature.

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