scholarly journals Two cases of angioimmunoblastic T-cell lymphoma with concomitant positive serology for acute Epstein-Barr virus infection

2017 ◽  
Vol 9 (3) ◽  
Author(s):  
Davide Facchinelli ◽  
Angela Polino ◽  
Francesco Dima ◽  
Alice Parisi ◽  
Achille Ambrosetti ◽  
...  
Keyword(s):  
T Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Epstein Barr Virus Infection ◽  
Positive Serology ◽  
Rare Type ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Barr Virus ◽  
Epstein Barr

Angioimmunoblastic T-cell lymphoma (AITL) is a rare type of peripheral T-cell lymphoma. Epstein-Barr virus (EBV) is known to be associated with pathogenesis and histological progression of AITL and the onset of the disease often mimics an infectious process. Here we describe two cases of patients with serology for acute EBV infection at the onset of AITL.

Is triple-positive serology for Epstein-Barr virus (VCA-IgG, VCA-IgM, EBNA-IgG) a specific feature of angioimmunoblastic T-cell lymphoma?

2019 ◽  
Vol 106 (5) ◽  
pp. 424-426
Author(s):  
Davide Facchinelli ◽  
Alice Parisi ◽  
Mauro Krampera ◽  
Dino Veneri
Keyword(s):  
T Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Prognostic Index ◽  
T Cell Lymphoma ◽  
Positive Serology ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Barr Virus ◽  
Number Of Patients ◽  
Epstein Barr

Purpose: We assessed the frequency of triple-positive serology (viral capsid antigen [VCA]–immunoglobulin G [IgG], VCA–immunoglobulin M, Epstein-Barr nuclear antigen–IgG) for Epstein-Barr virus (EBV) in a small number of patients with angioimmunoblastic T-cell lymphoma (AITL) at disease onset. Methods: Nine patients with newly diagnosed AITL were retrospectively enrolled in the present study. For all of them, EBV serology data were available. Results: Of 9 patients, 7 (77.7%) had a triple-positive serology (VCA-IgG, VCA-IgM, EBNA-IgG ) for EBV. These patients were characterized by bone marrow involvement, high incidence of thrombocytopenia, and poor prognosis according to Revised International Prognostic Index and Prognostic Index for Angioimmunoblastic T-cell Lymphoma scores. Conclusion: Assessment of both viremia and serology for EBV could be useful in patients with clinical and laboratory data suggesting lymphoma diagnosis; furthermore, although our data need to be validated in a larger cohort of patients, triple positivity for EBV serology might help to direct the diagnosis toward AITL.

scholarly journals Angioimmunoblastic T-cell lymphoma presenting with an acute serologic Epstein-Barr virus profile

2015 ◽  
Vol 7 (2) ◽  
Author(s):  
Timothy Beer ◽  
Patrick Dorion
Keyword(s):  
T Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Lymph Node Biopsy ◽  
T Cell Lymphoma ◽  
High Endothelial Venules ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Barr Virus ◽  
Epstein Barr ◽  
High Index Of Suspicion

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive peripheral T-cell lymphoma typically characterized by prominent lymphadenopathy and B-symptoms at the time of presentation, polyclonal hypergammaglobulinemia, autoimmune hemolysis and frequent but highly variable involvement of Epstein- Barr virus (EBV). Lymph node biopsy findings typically include effacement of nodal architecture, polymorphic infiltrate, atypical T-cells (usually CD4+/CD10+/PD1+) and prominent proliferations of high endothelial venules and follicular dendritic cells. However, this classic constellation of pathologic findings is often initially obscured by a prominence of EBV+ B-immunoblasts with or without associated peripherally circulating EBV DNA. Here we document the first reported case of an acute serologic EBV profile (VCA-IgM) in a patient with AITL, and we recommend that clinicians maintain a high index of suspicion for AITL in the appropriate clinical scenario, irrespective of Epstein-Barr related findings.

Human Ia-Like-Antigen-Expressed Cutaneous T Cell Lymphoma Associated with Epstein-Barr Virus Infection

Dermatology ◽  
1982 ◽  
Vol 165 (2) ◽  
pp. 100-107
Author(s):  
Fukumi Furukawa ◽  
Motoi Oguchi ◽  
Momoyo Hashimoto ◽  
Susumu Ohkawa ◽  
Motoaki Ozaki ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Epstein Barr Virus Infection ◽  
Cutaneous T Cell Lymphoma ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

Nasal T-cell lymphoma associated with Epstein-Barr virus infection

1993 ◽  
Vol 107 (5) ◽  
pp. 468-470 ◽  
Author(s):  
J. Dhaliwal ◽  
D. C. Rowlands ◽  
G. Niedobitek ◽  
A. Williams ◽  
A. Das Gupta ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
T Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

A case of nasal T-cell lymphoma in a Caucasian male is reported, in which the presence of Epstein-Barr virus within tumour cells was demonstrated by in situ hybridization to the Epstein-Barr virus encoded RNAs EBER-1 and EBER-2.

Alterations in ATR in nasal NK/T-cell lymphoma and chronic active Epstein-Barr virus infection

2006 ◽  
Vol 97 (7) ◽  
pp. 605-610 ◽  
Author(s):  
Angen Liu ◽  
Tetsuya Takakuwa ◽  
Wen-Juan Luo ◽  
Shigeki Fujita ◽  
Katsuyuki Aozasa
Keyword(s):  
T Cell ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Nk T Cell ◽  
Epstein Barr ◽  
Barr Virus Infection
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