scholarly journals Transient idiopathic central diabetes insipidus: is severe sepsis a possible cause?

2017 ◽  
Vol 11 (1) ◽  
pp. 78 ◽  
Author(s):  
Ilaria Lazzari ◽  
Alessandro Graziani ◽  
Federica Mirici ◽  
Giuseppe Francesco Stefanini
Keyword(s):  
Severe Sepsis ◽  
Case Report ◽  
Diabetes Insipidus ◽  
Kidney Failure ◽  
Central Diabetes Insipidus ◽  
Acute Kidney Failure ◽  
Neuron Activity ◽  
Vasopressin Release ◽  
Vasopressin Neuron ◽  
Possible Cause

Idiopathic central diabetes insipidus (CDI) is a disorder characterized by hypotonic polyuria and polydipsia, without any identified etiology. Here we report a case of a 57-year-old woman, with idiopathic CDI, admitted to our department with severe sepsis and acute kidney failure. After clinical and radiological investigations, she was diagnosed with idiopathic CDI. In this case report the findings suggest that severe sepsis could be the trigger for this disease. In addition, we hypothesise that apelin, a diuretic neuropeptide, plays a role in such a process. Apelin levels are known to increase during severe sepsis, which in turn counteracts vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release.

scholarly journals Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report

2015 ◽  
Vol 78 (4) ◽  
pp. 463 ◽  
Author(s):  
Yeun Seoung Choi ◽  
Jung Soo Lim ◽  
Woocheol Kwon ◽  
Soon-Hee Jung ◽  
Il Hwan Park ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Case Report ◽  
Diabetes Insipidus ◽  
Adult Male ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
Central Diabetes Insipidus ◽  
Pulmonary Langerhans Cell Histiocytosis

Central diabetes insipidus in neonate born at 24 weeks of pregnancy – Case report and review of literature

2017 ◽  
Vol 92 (2) ◽  
pp. 205-209
Author(s):  
Dawid Szpecht ◽  
Irmina Nowak ◽  
Agnieszka Ciesielska ◽  
Marta Szymankiewicz ◽  
Janusz Gadzinowski
Keyword(s):  
Case Report ◽  
Diabetes Insipidus ◽  
Central Diabetes Insipidus ◽  
Review Of Literature

Early Copeptin Determination Allows Prompt Diagnosis of Post-Neurosurgical Central Diabetes Insipidus

2019 ◽  
Vol 110 (6) ◽  
pp. 525-534 ◽  
Author(s):  
Alessandro Maria Berton ◽  
Filippo Gatti ◽  
Federica Penner ◽  
Emanuele Varaldo ◽  
Nunzia Prencipe ◽  
...  
Keyword(s):  
Diabetes Insipidus ◽  
Surrogate Marker ◽  
Pituitary Surgery ◽  
Central Diabetes Insipidus ◽  
Optimal Timing ◽  
Vasopressin Release ◽  
Biochemical Alterations ◽  
Post Surgery ◽  
Patients At Risk ◽  
Pituitary Lesion

Introduction: Central diabetes insipidus (CDI) is a frequent complication of pituitary surgery, but its diagnosis lacks standardized criteria. Copeptin, a surrogate marker of arginine vasopressin release, is triggered by psycho-physical stresses such as pituitary surgery. Low postoperative copeptin could predict CDI onset. The aims of this study were the validation of copeptin as a predictor of post-neurosurgical CDI and the identification of the optimal timing for its determination. Methods: Sixty-six consecutive patients operated for a hypothalamic-pituitary lesion were evaluated. Copeptin was determined preoperatively and at 1, 6, 12, 24 and 48 h post-extubation. Fifty-eight patients were reassessed after 3–6 months post-surgery to confirm transient (3 cases) or permanent CDI (5 cases) diagnosis. Results: A marked copeptin peak was identified at 1 h after extubation, when a value below or equal to 12.8 pmol/L had a good accuracy in identifying CDI cases (AUC 0.866, 95% CI 0.751–0.941). Moreover, a copeptin peak above 4.2 pmol/L excluded permanent forms (AUC 1, 95% CI 0.629–1). Regression analysis identified copeptin as the only significant predictor of CDI (OR 0.86, 95% CI 0.75–0.98, p = 0.02). A copeptin T1/T0 ratio below or equal to 1.47 identified patients at risk of isolated biochemical alterations even in the absence of an overt CDI. Conclusions: A prompt increase of copeptin is expected at 1 h after extubation. The absence of this peak is a reliable predictor of post-neurosurgical CDI.

scholarly journals Multifocal Fibrosclerosis as a Possible Cause of Panhypopituitarism with Central Diabetes Insipidus.

2000 ◽  
Vol 47 (3) ◽  
pp. 335-342 ◽  
Author(s):  
MASAHIKO KISHIMOTO ◽  
YASUHIKO OKIMURA ◽  
KEN-ICHI KIMURA ◽  
ISHIKAZU MIZUNO ◽  
GENZO IGUCHI ◽  
...  
Keyword(s):  
Diabetes Insipidus ◽  
Central Diabetes Insipidus ◽  
Multifocal Fibrosclerosis ◽  
Possible Cause

Newly Developed Central Diabetes Insipidus Following Kidney Transplantation: A Case Report

2013 ◽  
Vol 45 (7) ◽  
pp. 2804-2806 ◽  
Author(s):  
K.M. Kim ◽  
S.M. Kim ◽  
J. Lee ◽  
S.Y. Lee ◽  
S.K. Kwon ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Case Report ◽  
Diabetes Insipidus ◽  
Central Diabetes Insipidus
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