scholarly journals Systemic inflammation in patients with Takotsubo syndrome: a review of mechanistic and clinical implications

2021 ◽  
Author(s):  
Kenan Yalta ◽  
Ertan Yetkin ◽  
Tulin Yalta
Keyword(s):  
Systemic Inflammation ◽  
Acute Coronary Syndromes ◽  
The Other ◽  
Clinical Aspects ◽  
Clinical Implications ◽  
Takotsubo Syndrome ◽  
Inflammation Markers ◽  
Therapeutic Implications ◽  
Coronary Syndromes ◽  
General Perspective

Over recent decades, systemic inflammation  as  quantified  with  inflammation  markers  or  indices has been extensively  investigated  in the setting of  various  cardiovascular  conditions  including heart failure (HF),  acute coronary syndromes (ACS). In contrast, systemic inflammation  in patients with  takotsubo syndrome (TTS) has been an underrated  phenomenon in clinical practice. On the other hand, experimental and clinical data  have been  rapidly  accumulating  in the recent years  regarding   pathogenetic, prognostic as well as therapeutic implications of  systemic inflammation in TTS.  Accordingly, the present article  aims to provide a general perspective  on mechanistic and  clinical aspects of  systemic  inflammation in the setting of  TTS.

scholarly journals Important distinction between acute coronary syndromes and Takotsubo syndrome

2020 ◽  
Vol 17 (4) ◽  
pp. 258-258 ◽  
Author(s):  
Vincenzo Marafioti ◽  
Giulia Turri ◽  
Salvatore Monaco
Keyword(s):  
Acute Coronary Syndromes ◽  
Takotsubo Syndrome ◽  
Important Distinction ◽  
Coronary Syndromes

Systemic Inflammation and Arrhythmogenesis: A Review of Mechanistic and Clinical Perspectives

Angiology ◽  
2017 ◽  
Vol 69 (4) ◽  
pp. 288-296 ◽  
Author(s):  
Tulin Yalta ◽  
Kenan Yalta
Keyword(s):  
Systemic Inflammation ◽  
Limited Data ◽  
Therapeutic Implications ◽  
Cardiac Arrhythmogenesis ◽  
Potential Association ◽  
Potential Link ◽  
Coronary Syndromes ◽  
Clinical Phenomenon ◽  
Prognostic Implications ◽  
Arrhythmia Management

In the recent decades, systemic inflammation, as a clinical phenomenon, has been the focus of extensive research particularly with regard to its potential association with a variety of cardiovascular diseases including atherogenesis and acute coronary syndromes. Within this context, there also exists a potential link between systemic inflammation and cardiac arrhythmogenesis in various aspects. Accordingly, systemic inflammation response as measured with inflammation markers (cytokines, etc) has been investigated in the setting of well-known cardiac arrhythmias including atrial fibrillation and ventricular tachycardia. Based on current literature, clinical utility of these markers might potentially yield important prognostic implications in the setting of certain arrhythmogenic conditions. On the other hand, there exists limited data regarding therapeutic implications including clinical benefit of primary anti-inflammatory agents (corticosteroids, colchicine, etc) in the setting of arrhythmia management. The present review primarily aims to discuss potential triggers and fundamental mechanisms of inflammation-related arrhythmias along with a particular emphasis on clinical implications of systemic inflammation in the setting of cardiac arrhythmogenesis.

scholarly journals Biomarkers in ACS and Heart Failure: Should Men and Women Be Interpreted Differently?

2014 ◽  
Vol 60 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Shweta R Motiwala ◽  
Amy Sarma ◽  
James L Januzzi ◽  
Michelle L O'Donoghue
Keyword(s):  
Heart Failure ◽  
Risk Stratification ◽  
Acute Coronary Syndromes ◽  
Clinical Implications ◽  
Clinical Use ◽  
Men And Women ◽  
Reference Limits ◽  
Prognostic Utility ◽  
Coronary Syndromes ◽  
Triage Decisions

Abstract BACKGROUND Sex-based differences exist in the circulating concentrations of certain novel and established biomarkers in patients with acute coronary syndromes (ACS) and heart failure (HF). However, to date, few studies have compared the diagnostic and prognostic utility of these markers in men vs women. CONTENT This mini-review contains a discussion of the published reports of studies that have explored whether differences in biomarker concentrations exist between men and women with ACS or HF. It also examines those studies that have compared the utility of biomarkers for diagnosis or risk stratification in women vs men. Because biomarkers are often used to make therapeutic and triage decisions in patient care, the potential clinical implications for any observed differences in biomarker reference limits for men and women is discussed. SUMMARY Although the concentration distributions may differ between men and women for certain biomarkers in clinical use, the clinical implications of these observations remain unclear. Because elements of the pathophysiology of ACS and HF may differ between the sexes, further research is needed to better evaluate the diagnostic and prognostic utility of biomarkers in men vs women.

Inflammation in Acute Coronary Syndromes: Mechanisms and Clinical Implications

2004 ◽  
Vol 57 (5) ◽  
pp. 433-446 ◽  
Author(s):  
Dominick J. Angiolillo ◽  
Luigi M. Biasucci ◽  
Giovanna Liuzzo ◽  
Filippo Crea
Keyword(s):  
Acute Coronary Syndromes ◽  
Clinical Implications ◽  
Coronary Syndromes

scholarly journals Periodontal Disease, Inflammation and Atherosclerosis Progression in Patients with Acute Coronary Syndromes – the ATHERODENT Study

2018 ◽  
Vol 4 (1) ◽  
pp. 17-23
Author(s):  
Theodora Benedek ◽  
Ioana Rodean ◽  
Mihaela Ratiu ◽  
Nora Rat ◽  
Lia Yero Eremie ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Systemic Inflammation ◽  
Acute Coronary Syndromes ◽  
Left Ventricular ◽  
Oral Bacteria ◽  
Imaging Biomarkers ◽  
Atherosclerosis Progression ◽  
Atheromatous Plaques ◽  
Rate Of Progression ◽  
Coronary Syndromes

Abstract Recent studies have shown that systemic inflammation caused by periodontal disease (PD) can determine important changes in the coronary arteries, favoring atherosclerosis progression and the development of acute coronary syndromes (ACS). The aim of the ATHERODENT study (Protocol Record Number CM0117-ATD) is to assess the interrelation between PD, inflammation, and the progression of coronary atherosclerosis in patients with ACS. Material and methods: This case-control observational study will enroll 100 patients (group 1 – ACS and associated PD, and group 2 – ACS and no PD), in whom the following data will be collected: (1) demographic and clinical data; (2) cardiovascular risk factors; (3) full characterization of PD markers; (4) systemic inflammatory biomarkers; (5) imaging biomarkers derived from transthoracic echocardiography, computed tomography, coronary angiography, optical coherence tomography, and intravascular ultrasound; and (6) assessment of the presence of specific oral bacteria in samples of coronary plaques collected by coronary atherectomy, which will be performed during percutaneous revascularization interventions, when indicated in selected cases, in the atherectomy sub-study. The follow-up will be performed at 1, 3, 6, 12, 15, 18, and 24 months. The primary endpoint of the study will be represented by the rate of major adverse cardiovascular events (MACE) in PD vs. non-PD patients and in correlation with: (1) the level of systemic inflammation triggered by PD and/or by ACS at baseline; (2) the vulnerability degree of atheromatous plaques in the coronary tree (culprit and non-culprit lesions); and (3) the presence and burden of oral bacteria in atheromatous plaques. Secondary endpoints will be represented by: (1) the rate of progression of vulnerability degree of non-culprit coronary plaques; (2) the rate of progression of atheromatous burden and calcium scoring of the coronary tree; and (3) the rate of occurrence of left ventricular remodeling and post-infarction heart failure. The ATHERODENT study has been registered in clinicaltrials.gov (ClinicalTrials.gov Identifier: NCT03395041).

scholarly journals Natriuretic peptides and multimarker approach to risk stratification of patients with acute coronary syndromes

2006 ◽  
Vol 59 (5-6) ◽  
pp. 248-252 ◽  
Author(s):  
Radomir Matunovic ◽  
Aleksandar Stojanovic ◽  
Zdravko Mijailovic ◽  
Zoran Cosic
Keyword(s):  
Heart Failure ◽  
Risk Stratification ◽  
Natriuretic Peptides ◽  
Acute Coronary Syndromes ◽  
Cardiac Biomarkers ◽  
Therapeutic Implications ◽  
Coronary Syndrome ◽  
Brain Natriuretic Peptides ◽  
Coronary Syndromes ◽  
St Elevation

Natriuretic peptides in acute coronary syndromes Brain natriuretic peptides (BNP) and N-terminal prohormone brain natriuretic peptides (N-proBNP) have been shown to provide important prognostic information in patients with acute coronary syndrome (ACS). Ischemia may be an important stimulus for BNP release. This does not imply, however, that BNP is useful for diagnosing ischemia, and BNP is unlikely to prove sensitive or specific enough for this purpose. Significance of natriuretic peptides in assessing prognosis in patients with acute coronary syndromes In patients with ST-elevation and non-ST-elevation myocardial infarction, higher BNP and N-proBNP levels have been shown to predict a grater likelihood of death or heart faiulure, independent of other prognostic factors. Therapeutic implications of BNP elevation in acute coronary syndromes Patients with BNP or NT-proBNP elevation following ACS are clearly at high risk for death and for developement of heart failure, but specific therapeutic implications of BNP elevation have not been defined. In particular, it is not known how patients with BNP elevation should be treated considering the fact that they have normal troponin levels and no clinical evidence of heart failure. Multimarker strategies for risk stratification in acute coronary syndromes It has been shown recently that in patients with acute coronary syndromes the risk increased sequentially among those with one, two or three elevated biomarkers. Therapeutic applications of cardiac biomarkers in acute coronary syndromes Multimarker strategies, that incorporate panels of cardiac bio?markers, are likely to be used in the future for risk stratification and for pathophysiologically-guided treatement of patients with ACS.

SAT0599 Autoimmnune Disease in Acute Coronary Syndromes. Clinical Implications

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 886.3-886
Author(s):  
N. Lozano-Rivas ◽  
C. Marras-Fernández Cid ◽  
P. Flores-Blanco ◽  
F.J. Pastor-Perez ◽  
L.F. Linares ◽  
...  
Keyword(s):  
Acute Coronary Syndromes ◽  
Clinical Implications ◽  
Coronary Syndromes
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