scholarly journals Endothelin receptor antagonists: effects on extracellular matrix synthesis in primary cultures of skin fibroblasts from systemic sclerosis patients

Reumatismo ◽  
2012 ◽  
Vol 64 (5) ◽  
Author(s):  
S. Soldano ◽  
P. Montagna ◽  
R. Brizzolara ◽  
C. Ferrone ◽  
A. Parodio ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Systemic Sclerosis ◽  
Primary Cultures ◽  
Skin Fibroblasts ◽  
Endothelin Receptor Antagonists ◽  
Endothelin Receptor ◽  
Matrix Synthesis ◽  
Receptor Antagonists

scholarly journals Endothelin Receptor Antagonists for the Treatment of Raynaud's Phenomenon and Digital Ulcers in Systemic Sclerosis

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Kait Arefiev ◽  
David F. Fiorentino ◽  
Lorinda Chung
Keyword(s):  
Systemic Sclerosis ◽  
Case Reports ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Digital Ulcers ◽  
Endothelin Receptor Antagonists ◽  
Endothelin Receptor ◽  
Significant Morbidity ◽  
Receptor Antagonists ◽  
Internal Organs

Systemic sclerosis is a connective tissue disease characterized by fibrosis of the skin, internal organs, and widespread vasculopathy. Raynaud's phenomenon and digital ulcers are vascular manifestations of this disease and cause significant morbidity. Current treatments are only moderately effective in reducing the severity of Raynaud's in a portion of patients and typically do not lead to substantial benefit in terms of the healing or prevention of digital ulcers. Several studies have evaluated the efficacy of targeting the vasoconstrictor endothelin-1 for the treatment of systemic sclerosis-associated vascular disease. The purpose of this paper is to summarize the published studies and case reports evaluating the efficacy of endothelin receptor antagonists in the treatment of Raynaud's phenomenon and digital ulcers associated with systemic sclerosis.

ChemInform Abstract: 2-Aryloxycarbonylthiophene-3-sulfonamides: Highly Potent and ETA Selective Endothelin Receptor Antagonists.

ChemInform ◽  
2010 ◽  
Vol 28 (50) ◽  
pp. no-no
Author(s):  
B. RAJU ◽  
C. WU ◽  
R. CASTILLO ◽  
I. OKUN ◽  
F. STAVROS ◽  
...  
Keyword(s):  
Endothelin Receptor Antagonists ◽  
Endothelin Receptor ◽  
Receptor Antagonists

Multiple Compound-Related Adverse Properties Contribute to Liver Injury Caused by Endothelin Receptor Antagonists

2014 ◽  
Vol 352 (2) ◽  
pp. 281-290 ◽  
Author(s):  
J. Gerry Kenna ◽  
Simone H. Stahl ◽  
Julie A. Eakins ◽  
Alison J. Foster ◽  
Linda C. Andersson ◽  
...  
Keyword(s):  
Liver Injury ◽  
Endothelin Receptor Antagonists ◽  
Endothelin Receptor ◽  
Receptor Antagonists

Endothelin receptor antagonists: Actions and rationale for their development

1994 ◽  
Vol 48 (4) ◽  
pp. 625-635 ◽  
Author(s):  
Timothy D. Warner ◽  
Bruno Battistini ◽  
Annette M. Doherty ◽  
Roger Corder
Keyword(s):  
Endothelin Receptor Antagonists ◽  
Endothelin Receptor ◽  
Receptor Antagonists
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