scholarly journals Adult type granulosa cell tumor in adult testis: report of a case and review of the literature

Rare Tumors ◽  
2011 ◽  
Vol 3 (4) ◽  
pp. 117-119 ◽  
Author(s):  
Zhao Song ◽  
David J. Vaughn ◽  
Zhanyong Bing
Keyword(s):  
Alkaline Phosphatase ◽  
Granulosa Cell ◽  
Epithelial Membrane Antigen ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Adult Type ◽  
Adult Testis ◽  
Granulosa Cell Tumors ◽  
Hmb 45

Granulosa cell tumors can be classified into juvenile and adult types and more commonly occur in ovaries. Adult testicular granulosa cell tumors are extremely rare and only 29 cases of adult type have previously been reported. We report here a 28-year old Caucasian man with a left testicular adult type granulosa cell tumor. The tumor measured 2.6×2.6×2.5 cm and was mitotically active (10/10 HPF). Immunohistochemical stains showed the tumor diffusely positive for inhibin and vimentin, and negative for epithelial membrane antigen, cytokeratins, synaptophysin, HMB-45, OCT-4, placental-like alkaline phosphatase and lymphoid markers. The reported granulosa cell tumors in adult testis were briefly reviewed.

scholarly journals Adult Testicular Granulosa Cell Tumor: A Review of the Literature for Clinicopathologic Predictors of Malignancy

2011 ◽  
Vol 135 (1) ◽  
pp. 143-146 ◽  
Author(s):  
Joshua Anspach Hanson ◽  
Abiy B. Ambaye
Keyword(s):  
Granulosa Cell ◽  
Case Reports ◽  
Granulosa Cell Tumor ◽  
Malignant Potential ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Stromal Tumors ◽  
Granulosa Cell Tumors ◽  
Pathologic Features ◽  
Sex Cord Stromal Tumors

Abstract Adult testicular granulosa cell tumors are rare sex cord–stromal tumors of which only 28 have been previously reported. As compared with their ovarian counterparts, these tumors may follow a more aggressive course because the proportion of malignant cases is higher. To date, there are no clinical or pathologic features that definitively predict malignancy. We reviewed all prior case reports for features that may predict their malignant potential. Tumor size greater than 5.0 cm is the only feature statistically associated with malignancy. Mitotic count, tumor necrosis, patient age, and the presence of gynecomastia do not, at present, predict benign versus malignant behavior.

Granulosa cell tumor of the adult testis: A clinicopathologic study of seven cases and a review of the literature

1993 ◽  
Vol 24 (10) ◽  
pp. 1120-1126 ◽  
Author(s):  
Laura P. Jimenez-Quintero ◽  
Jae Y. Ro ◽  
Angel Zavala-Pompa ◽  
Mahul B. Amin ◽  
Bernard Tetu ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Adult Testis ◽  
Clinicopathologic Study

FOXL2 Mutations in Granulosa Cell Tumors Occurring in Males

2012 ◽  
Vol 136 (7) ◽  
pp. 825-828 ◽  
Author(s):  
Joema F. Lima ◽  
Long Jin ◽  
Ana Rose C. de Araujo ◽  
Michele R. Erikson-Johnson ◽  
Andre M. Oliveira ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Leydig Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Testicular Tumors ◽  
Adult Type ◽  
Male Adult ◽  
Granulosa Cell Tumors ◽  
Juvenile Granulosa Cell Tumor ◽  
Leydig Cell Tumors

Context.—Granulosa cell tumors comprise less than 5% of ovarian tumors in women and are much rarer in men, with only about 20 cases reported, to our knowledge. Recently, a somatic mutation of FOXL2 was reported in virtually all adult-type granulosa cell tumors in women. Objective.—To investigate FOXL2 mutations in granulosa cell tumors occurring in males. Design.—Five cases of an adult-type granulosa cell tumor from males were selected from the files of the Mayo Clinic. Nine other testicular tumors (1 juvenile granulosa cell tumor, 5 Leydig cell tumors, and 3 Sertoli-Leydig cell tumors) were evaluated for comparison. Inhibin immunostain was performed in all cases. DNA was extracted from formalin-fixed, paraffin-embedded tissue, followed by polymerase chain reaction and direct sequencing of FOXL2. Results.—All 5 cases had classic histopathologic features of the adult-type granulosa cell tumor. Inhibin was diffusely positive in all cases. FOXL2 402C→G (C134W) was identified in 40% (2 of 5) of the male, adult-type granulosa cell tumors. Of the 2 tumors positive for the mutation, 1 occurred in the testis of a man, and the other one affected the abdominal ovaries of a phenotypically male patient. All other testicular tumors were negative for the mutation. Conclusions.—The FOXL2 402C→G (C134W) mutation is also present in adult-type granulosa cell tumors occurring in men, although in a smaller proportion when compared with the rates reported in women. FOXL2 mutational analysis can be a helpful in the diagnosis of granulosa cell tumors of the testis.

Adult Type Testicular Granulosa Cell Tumor: Case Report and Review of the Literature

2006 ◽  
Vol 73 (3) ◽  
pp. 297-301
Author(s):  
G. Lucarelli ◽  
V. Mancini ◽  
G. Annunziata ◽  
S. Trabucco ◽  
S. Palazzo ◽  
...  
Keyword(s):  
Case Report ◽  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Adult Type

scholarly journals Adult type granulosa cell tumor of the testis with a heterologous sarcomatous component: case report and review of the literature

2014 ◽  
Vol 9 (1) ◽  
pp. 107 ◽  
Author(s):  
Thomas EO Schubert ◽  
Robert Stoehr ◽  
Arndt Hartmann ◽  
Sabrina Schöne ◽  
Mathias Löbelenz ◽  
...  
Keyword(s):  
Case Report ◽  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Sarcomatous Component ◽  
Adult Type ◽  
Component Case

Malignant advanced granulosa cell tumor of the adult testis: case report and review of the literature

2008 ◽  
Vol 39 (5) ◽  
pp. 701-709 ◽  
Author(s):  
Kai H. Hammerich ◽  
Stephanie Hille ◽  
Gustavo E. Ayala ◽  
Thomas M. Wheeler ◽  
Rainer Engers ◽  
...  
Keyword(s):  
Case Report ◽  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Adult Testis

Mixed Ovarian Tumor Composed of Brenner Tumor and Adult-Type Granulosa Cell Tumor: A Case Report of a Very Rare Mixed Ovarian Tumor and a Review of the Literature

2017 ◽  
Vol 26 (4) ◽  
pp. 382-387
Author(s):  
Judit Tamás ◽  
Ildikó Vereczkey ◽  
Erika Tóth ◽  
Erzsébet Csernák ◽  
Katalin Purcsi ◽  
...  
Keyword(s):  
Case Report ◽  
Granulosa Cell ◽  
Ovarian Tumor ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Ovarian Tumors ◽  
Review Of The Literature ◽  
Adult Type ◽  
Histologic Subtype ◽  
Brenner Tumor

A combination of ovarian tumors with the same histogenetic origin but different histologic subtype is relatively common, whereas a co-occurrence of tumors with different histogenetic origin is rare. We report a case of mixed ovarian tumor composed of Brenner tumor and adult-type granulosa cell tumor, a combination that to the best of our knowledge has not been reported in the literature until now.

Testicular granulosa cell tumor of adult type: A new case and a review of the literature

2007 ◽  
Vol 25 (4) ◽  
pp. 322-325 ◽  
Author(s):  
Pasquale Ditonno ◽  
Giuseppe Lucarelli ◽  
Michele Battaglia ◽  
Vito Mancini ◽  
Silvano Palazzo ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Type A ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Adult Type

scholarly journals Adult type granulosa cell tumor of the testis: Radiological evaluation and review of the literature

2014 ◽  
Vol 40 (2) ◽  
pp. 115-119 ◽  
Author(s):  
Ioannis Tsitouridis ◽  
Charalampos Maskalidis ◽  
Aikaterini Sdrolia ◽  
Stavroula Pervana ◽  
Elissavet Pazarli ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Radiological Evaluation ◽  
Review Of The Literature ◽  
Adult Type

scholarly journals Granulosa cell tumor of the adult testis: report of a case and review of the literature

Clinics ◽  
2006 ◽  
Vol 61 (1) ◽  
pp. 77-78 ◽  
Author(s):  
Marcelo Hisano ◽  
Frederico Mota Mascarenhas Souza ◽  
Denise Maria Avancini Costa Malheiros ◽  
Antonio Carlos Lima Pompeo ◽  
Antonio Marmo Lucon
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Adult Testis
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