Double-Blind, Randomized, Placebo-Controlled Trial of Topiramate Plus Cognitive-Behavior Therapy in Binge-Eating Disorder

2007 ◽  
Vol 68 (09) ◽  
pp. 1324-1332 ◽  
Author(s):  
Angélica M. Claudino ◽  
Irismar R. de Oliveira ◽  
José Carlos Appolinario ◽  
Táki A. Cordás ◽  
Monica Duchesne ◽  
...  
2007 ◽  
Vol 29 (1) ◽  
pp. 23-25 ◽  
Author(s):  
Mônica Duchesne ◽  
José Carlos Appolinario ◽  
Bernard Pimentel Rangé ◽  
Julia Fandiño ◽  
Tatiana Moya ◽  
...  

OBJECTIVE: To assess the effectiveness of a manual-based cognitive behavior therapy adapted to a group format in a sample of Brazilian obese subjects with binge-eating disorder. METHOD: In an open trial, 21 obese subjects with binge-eating disorder received a group cognitive-behavioral therapy program. Changes in binge-eating frequency, weight, body shape concerns, and depressive symptoms were compared between baseline and the end of the study. RESULTS: The mean frequency of binge-eating episodes significantly decreased from baseline to post-treatment (p < 0.001), with a binge eating remission rate of 76.1% at the end of the trial. Depressive symptoms and body shape concern also improved (p < 0.001). In addition, weight loss was statistically and clinically significant. CONCLUSION: The use of this adapted manual-based cognitive behavior therapy in this sample resulted in a marked improvement in binge-eating, weight, body shape concern, and depressive symptoms related to binge-eating disorder.


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