Neural predictors of cognitive-behavior therapy outcome in anxiety-related disorders: a meta-analysis of task-based fMRI studies

Background Cognitive-behavior therapy (CBT) is a well-established first-line intervention for anxiety-related disorders, including specific phobia, social anxiety disorder, panic disorder/agoraphobia, generalized anxiety disorder, obsessive-compulsive disorder, and posttraumatic stress disorder. Several neural predictors of CBT outcome for anxiety-related disorders have been proposed, but previous results are inconsistent. Methods We conducted a systematic review and meta-analysis of task-based functional magnetic resonance imaging (fMRI) studies investigating whole-brain predictors of CBT outcome in anxiety-related disorders (17 studies, n = 442). Results Across different tasks, we observed that brain response in a network of regions involved in salience and interoception processing, encompassing fronto-insular (the right inferior frontal gyrus-anterior insular cortex) and fronto-limbic (the dorsomedial prefrontal cortex-dorsal anterior cingulate cortex) cortices was strongly associated with a positive CBT outcome. Conclusions Our results suggest that there are robust neural predictors of CBT outcome in anxiety-related disorders that may eventually lead (probably in combination with other data) to develop personalized approaches for the treatment of these mental disorders.

Role of Psychology Treatment in "Anxiety Disorder"

In order to manage the emotional and psychological problems in special population such as mental retardation. HIV positive cases and so on. A comprehensive management of this type of cases includes psychotherapy. Here it is necessary to know about this concept and its beauty in various disorders. It is a psychological method which is called psychotherapy (Talking Cure). Psychotherapy is a systematic attempt to manage the mental and emotional disorders with the help of psychological means a variant of this approach came in 1960s. Which was called cognitive behavior therapy. Recent days this approached has been brought revolution in management of psychological, behavioral and emotional problems. This paper will enhance our knowledge regarding status of psychological method in various disorders and mental illnesses.