scholarly journals Primary progressive aphasia: A comparative study of progressive nonfluent aphasia and semantic dementia

2005 ◽  
Vol 53 (2) ◽  
pp. 162 ◽  
Author(s):  
PS Mathuranath ◽  
Annamma George
Keyword(s):  
Comparative Study ◽  
Primary Progressive Aphasia ◽  
Semantic Dementia ◽  
Nonfluent Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Progressive Nonfluent Aphasia

Primary Progressive Aphasia and Its Three Variants

2010 ◽  
Vol 20 (1) ◽  
pp. 5-12
Author(s):  
Jennifer M. Ogar
Keyword(s):  
Case Studies ◽  
Clinical Symptoms ◽  
Primary Progressive Aphasia ◽  
Semantic Dementia ◽  
Speech Language Pathologists ◽  
Nonfluent Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Progressive Nonfluent Aphasia

Abstract Speech-language pathologists are increasingly treating patients with progressive disorders, including primary progressive aphasia (PPA). For many years, two variants of PPA were recognized: a nonfluent type—progressive nonfluent aphasia (PNFA)—and a fluent form—semantic dementia (SD). In 2004, a third variant—logopenic progressive aphasia (LPA)—was described. This article will review clinical symptoms, neuroimaging correlates, and the neuropathologies that are typically associated with PNFA, SD, and LPA. Case studies are included to further illustrate the characteristics of each of these three PPA variants.

Primary Progressive Aphasia and Semantic Dementia

2006 ◽  
Vol 16 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Maya L. Henry ◽  
Pélagie Beeson
Keyword(s):  
Primary Progressive Aphasia ◽  
Semantic Dementia ◽  
Progressive Aphasia ◽  
Primary Progressive

Semantic dementia (semantic variant primary progressive aphasia)

2016 ◽  
pp. 178-193
Author(s):  
John R. Hodges ◽  
Sharon Savage ◽  
Karalyn E. Patterson
Keyword(s):  
Primary Progressive Aphasia ◽  
Semantic Dementia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Semantic Variant

scholarly journals An Overview on Primary Progressive Aphasia and Its Variants

2006 ◽  
Vol 17 (2) ◽  
pp. 77-87 ◽  
Author(s):  
Serena Amici ◽  
Maria Luisa Gorno-Tempini ◽  
Jennifer M. Ogar ◽  
Nina F. Dronkers ◽  
Bruce L. Miller
Keyword(s):  
Language Impairment ◽  
Sentence Comprehension ◽  
Primary Progressive Aphasia ◽  
Cognitive Domains ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Word Finding ◽  
Degenerative Disorder ◽  
Language Output ◽  
Progressive Nonfluent Aphasia

We present a review of the literature on Primary Progressive Aphasia (PPA) together with the analysis of neuropschychological and neuroradiologic profiles of 42 PPA patients. Mesulam originally defined PPA as a progressive degenerative disorder characterized by isolated language impairment for at least two years. The most common variants of PPA are: (1) Progressive nonfluent aphasia (PNFA), (2) semantic dementia (SD), (3) logopenic progressive aphasia (LPA). PNFA is characterized by labored speech, agrammatism in production, and/or comprehension. In some cases the syndrome begins with isolated deficits in speech. SD patients typically present with loss of word and object meaning and surface dyslexia. LPA patients have word-finding difficulties, syntactically simple but accurate language output and impaired sentence comprehension. The neuropsychological data demonstrated that SD patients show the most characteristic pattern of impairment, while PNFA and LPA overlap within many cognitive domains. The neuroimaging analysis showed left perisylvian region involvement. A comprehensive cognitive, neuroimaging and pathological approach is necessary to identify the clinical and pathogenetic features of different PPA variants.

scholarly journals Verbal and non-verbal semantic impairment: From fluent primary progressive aphasia to semantic dementia

2007 ◽  
Vol 1 (2) ◽  
pp. 203-211 ◽  
Author(s):  
Mirna Lie Hosogi Senaha ◽  
Paulo Caramelli ◽  
Claudia Sellitto Porto ◽  
Ricardo Nitrini
Keyword(s):  
Semantic Memory ◽  
Primary Progressive Aphasia ◽  
Semantic Dementia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Paired Control ◽  
Language Evaluations ◽  
Episodic Memories ◽  
State Examination ◽  
Selective Impairment

Abstract Selective disturbances of semantic memory have attracted the interest of many investigators and the question of the existence of single or multiple semantic systems remains a very controversial theme in the literature. Objectives: To discuss the question of multiple semantic systems based on a longitudinal study of a patient who presented semantic dementia from fluent primary progressive aphasia. Methods: A 66 year-old woman with selective impairment of semantic memory was examined on two occasions, undergoing neuropsychological and language evaluations, the results of which were compared to those of three paired control individuals. Results: In the first evaluation, physical examination was normal and the score on the Mini-Mental State Examination was 26. Language evaluation revealed fluent speech, anomia, disturbance in word comprehension, preservation of the syntactic and phonological aspects of the language, besides surface dyslexia and dysgraphia. Autobiographical and episodic memories were relatively preserved. In semantic memory tests, the following dissociation was found: disturbance of verbal semantic memory with preservation of non-verbal semantic memory. Magnetic resonance of the brain revealed marked atrophy of the left anterior temporal lobe. After 14 months, the difficulties in verbal semantic memory had become more severe and the semantic disturbance, limited initially to the linguistic sphere, had worsened to involve non-verbal domains. Conclusions: Given the dissociation found in the first examination, we believe there is sufficient clinical evidence to refute the existence of a unitary semantic system.

scholarly journals Brief intervention for agrammatism in Primary Progressive Nonfluent Aphasia: A case report

2014 ◽  
Vol 8 (3) ◽  
pp. 291-296 ◽  
Author(s):  
Thais Helena Machado ◽  
Aline Carvalho Campanha ◽  
Paulo Caramelli ◽  
Maria Teresa Carthery-Goulart
Keyword(s):  
Syntactic Structure ◽  
Primary Progressive Aphasia ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Nonfluent Aphasia ◽  
Primary Progressive ◽  
Functional Aspects ◽  
Verbal Production ◽  
Progressive Nonfluent Aphasia

The non-fluent and agrammatic variant of Primary Progressive Aphasia (NFPPA) is characterized by reduced verbal production with deficits in building grammatically correct sentences, involving dysfunctions in syntactic and morphological levels of language. There are a growing number of studies about non-pharmacological alternatives focusing on the rehabilitation of functional aspects or specific cognitive impairments of each variant of PPA. This study reports a short-term treatment administered to a patient with NFPPA focusing on the production of sentences. The patient had significant reduction in verbal fluency, use of keywords, phrasal and grammatical simplifying as well as anomia. Using the method of errorless learning, six sessions were structured to stimulate the formation of sentences in the present and past with the cloze technique. The patient had improvement restricted to the strategy, with 100% accuracy on the trained phrases and generalization to untrained similar syntactic structure after training. These results persisted one month after the treatment.

Semantic Dementia and Primary Progressive Aphasia: A Problem of Categorization?

2005 ◽  
Vol 19 (Supplement 1) ◽  
pp. S7-S14 ◽  
Author(s):  
Jonathan A Knibb ◽  
John R Hodges
Keyword(s):  
Primary Progressive Aphasia ◽  
Semantic Dementia ◽  
Progressive Aphasia ◽  
Primary Progressive
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