scholarly journals Efficacy and Safety of Medium-to-long-term Use of Tolterodine Extended Release with or without Tamsulosin in Patients with Benign Prostate Hyperplasia and Larger Prostate Size

2016 ◽  
Vol 129 (24) ◽  
pp. 2899-2906 ◽  
Author(s):  
Jian-Liang Cai ◽  
Zhe Zhou ◽  
Yan Yang ◽  
Yi-Fu Yan ◽  
Shuo Jing ◽  
...  
2017 ◽  
Vol 9 (3) ◽  
pp. 223
Author(s):  
Kawaljit Singh ◽  
RahulJanak Sinha ◽  
Ashok Sokhal ◽  
Vishwajeet Singh

2019 ◽  
Vol 3 (3) ◽  
pp. 49-50
Author(s):  
Zulfa Ichsanniyati R. Ciwi Fadhlillah ◽  
I Nengah Yogiswari ◽  
Siti Zaenab ◽  
Deni Noviana ◽  
Sukmasari Arifah

An 9-years-old male pug was examined for stranguria and letargic in one week. The dog has no testicles as the owner claimed that the dog had been castrated a few years ago. Abdominal palpation shows bladder retention filled with urine but no blockage was found. Urine sedimentation contained blood and few unknown crystal. Hematology showed mild anemia and leukocytosis while blood chemistry only found mild hyperglobulinemia. Radiography showed prostate enlargement. Ultrasound examination was showing mild nephrolithiasis, cystitis and prostatic enlargement. Diagnosis of benign prostate hyperplasia is suspected but doubtful because the animal has been castrated. Differential diagnose was prostatic cysts, infection and cancer. The dog received finasteride 1 mg/kg twice a day orally for 60 days and antibiotic. Urine catheter was temporarily installed to evacuate urine twice a day. Post treatment ultrasound was performed 20 days later and showed evident involution of prostate sizes. An enlarge irregular testicle was also found in right dorsolateral of bladder. Monorchid castration was performed at 60 days of finasteride. The dog was diagnosed with monorchid induce benign prostate hyperplasia from the radiography and ultrasonography. The prostate size was reduced after finasteride administration


PRILOZI ◽  
2017 ◽  
Vol 38 (2) ◽  
pp. 123-129 ◽  
Author(s):  
Skender Saidi ◽  
Sotir Stavridis ◽  
Oliver Stankov ◽  
Sasho Dohcev ◽  
Sasho Panov

Abstract An increasing tendency has recently emerged for the use of phytotherapeutic agents as alternative to commercial pharmacological agents for the treatment of benign prostate hyperplasia (BPH). The purpose of this study is to evaluate the effects of Serenoa repens alcohol extract treatment on BPH patients’ symptoms and major parameters during one-year follow-up. The study was performed on 70 men aged 40 - 79 years (mean 60.58) with symptomatic BPH that were divided into a group of 40 patients treated with Serenoa repens extract (SRT) and a control group of 30 patients that received no treatment and were observed only. The following parameters were determined at the time of diagnosis (baseline), and after 6 and 12 months: prostate size, serum prostate-specific antigen (PSA) and uroflowmetry parameters including maximum flow rate (MFR), average flow rate (AFR) and post-voiding residual volume (PVRV). In addition, the relevant patient symptoms were evaluated using the International Prostate Symptom Score (IPSS) system. The patients in the SRT group showed a statistically significant increment of the average MFR and AFR values and reduction of PV relative to the control group (p<0.05). The significant differences between the proportion of patients with prostate volume >40 ml in the SRE treated group vs. control group was observed (p<0.05). The mean IPSS score was highly significantly reduced in the SRT group (p<0.01). The mild improvements of the urine flow, prostate size and IPSS score during 12 months treatment with the Serenoa repens extract indicate possible efficiency of this phytotherapeutic agent in patients with BPH.


2021 ◽  
Author(s):  
Peng Gu ◽  
Xiaoliang He ◽  
Minhao Zhang

Abstract Purpose: To evaluate the clinical curative effect and safety of plasmakinetic enucleation of the prostate (PKEP) in different stages versus plasmakinetic resection of the prostate (PKRP) in the treatment for benign prostate hyperplasia (BPH). Methods: Clinical data of 171 hospitalized patients who suffered from BPH undergoing PKEP or PKRP were collected. All patients were separated into PKEP1 group (n = 44, between July 2018 to June 2019), PKRP group (n = 72, between July 2018 to June 2020), and PKEP2 group (n = 55, between July 2019 to June 2020). General preoperative clinical data, perioperative and postoperative results, and complications were recorded and analyzed among the 3 groups. Results: The hemoglobin change in the PKEP1 and PKEP2 were more slightly than that in the PKRP (P > 0.05). Compared with PKRP, more prostate weight was removed in PKEP1 and PKEP2 (P < 0.05). The operation time of PKEP2 was reduced significantly (P < 0.05), compared with PKEP1 and PKRP. We further found the ratio of operation time to prostate volume(çrsç = 0.630, P < 0.001), and the ratio of operation time to enucleation weight(çrsç = 0.540, P < 0.001) were both decreased with the increase of the number of surgical cases. Compared with preoperative results, postoperative 3-month IPSS, QOL and RUV decreased, while Qmax increased in the 3 groups (P < 0.05). Conclusion: In terms of surgical safety and efficacy, skilled PKEP was comparable with PKRP, in addition it is superior to PKRP in operation time and enucleation weight.


2021 ◽  
Vol 8 ◽  
Author(s):  
Wen Su ◽  
Ye Yi ◽  
Liang Zeng ◽  
Jin Tang

Objective: To evaluate the safety and efficacy of transurethral plasmakinetic enucleation of the prostate (PKERP) vs. transurethral resection of the prostate (TURP) in elderly patients aged ≥80 years with benign prostate hyperplasia.Materials and Methods: We conducted a retrospective analysis of the PKERP (n = 123) and TURP (n = 143) in patients aged ≥80 years at urology department of The Third Xiangya Hospital of Central South University from January 2016 to October 2019. Then the preoperative, intraoperative, and postoperative data of different indicators were compared between the two groups. The follow-up was done at 3 months, 1 year after surgical treatment.Results: No significant differences were observed between the two groups for the baseline characteristics, including age, prostate volume, prostate-specific antigen (PSA) level, concurrent disease, maximum urinary flow rate (MFR), international prostate symptoms score (IPSS), and quality of life (QoL) score. The operative time, hemoglobin decrease, and postoperative flushing time were significantly lower in the PKERP group compared with the TURP group. However, no significant differences were observed between both groups for postoperative hospital stay, incidence of transurethral resection syndrome (TURS), prostatic capsular perforation, and genuine urinary incontinence. The follow-up results showed that the MFR of the PKERP group was significantly higher than the TURP group at 1 year after surgery.Conclusion: Compared with TURP, PKERP is a safe and efficacious method for treating patients aged ≥80 years with benign prostate hyperplasia, and it may improve long-term urination symptoms.


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