Histopathological pattern of lymphomas and clinical presentation and outcomes of diffuse large B cell lymphoma: A multicenter registry based study from India

ABSTRACT Lymphomas of the oral cavity are rare and typically present as intraosseous lesions that are most commonly diffuse large B-cell type. Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell lymphoma histologically characterized by diffuse proliferation of large neoplastic B-lymphoid cells with a nuclear size equal to or exceeding normal histiocytic nuclei. A case of DLBCL of the mandible in an 18 years old male patient is presented. This report discusses this rare malignancy, including clinical presentation, histopathologic features, immunologic profile, treatment and prognosis. Though lymphoma of mandible is rare, it must be considered in differential diagnosis of swellings arising in the region. How to cite this article Alshahrani FAA, Aljabab AS, Motabi IHM, Alrashed A, Anil S. Primary Diffuse Large B-cell Lymphoma involving the Mandible. J Contemp Dent Pract 2015;16(10):840-844.

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Lacrimal gland anaplastic kinase-positive large B-cell lymphoma (LBCL-ALK+) with an atypical clinical presentation

Clinical and Experimental Ophthalmology ◽

10.1111/ceo.12702 ◽

2016 ◽

Vol 44 (6) ◽

pp. 520-522 ◽

Cited By ~ 1

Author(s):

Ana F Duarte ◽

Jeremy A Squire ◽

Fernando Chahud ◽

Antonio AV Cruz

Keyword(s):

B Cell ◽

Lacrimal Gland ◽

Clinical Presentation ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Large B Cell Lymphoma ◽

Atypical Clinical Presentation ◽

Large B Cell

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Sudden onset of blindness and multiple migratory skin nodules as initial clinical presentation of intravascular large B-cell lymphoma

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2015.02.263 ◽

2015 ◽

Vol 72 (5) ◽

pp. AB63

Keyword(s):

B Cell ◽

Clinical Presentation ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Sudden Onset ◽

Large B Cell Lymphoma ◽

Skin Nodules ◽

Large B Cell

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Diffuse large B-cell lymphoma (DLBCL) with bone marrow (BM) involvement. clinical presentation, central nervous system (CNS) relapses, and outcomes of 121 patients treated at M. D. Anderson Cancer Center.

Journal of Clinical Oncology ◽

10.1200/jco.2010.28.15_suppl.8072 ◽

2010 ◽

Vol 28 (15_suppl) ◽

pp. 8072-8072

Author(s):

G. F. Perini ◽

J. E. Romaguera ◽

M. A. Rodriguez ◽

B. Pro ◽

A. Younes ◽

...

Keyword(s):

Central Nervous System ◽

Bone Marrow ◽

Nervous System ◽

B Cell ◽

Clinical Presentation ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Cancer Center ◽

Large B Cell Lymphoma ◽

Large B Cell

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Reply to: [Comment to: The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement. Haematologica 2007; 92:1335-1342

Haematologica ◽

10.3324/haematol.13220 ◽

2008 ◽

Vol 93 (7) ◽

pp. e54-e54 ◽

Cited By ~ 2

Author(s):

H. Avet-Loiseau

Keyword(s):

B Cell ◽

Clinical Presentation ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Large B Cell Lymphoma ◽

Large B Cell

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Rapidly progressive diffuse large B-cell lymphoma with initial clinical presentation mimicking seronegative Wegener's granulomatosis

European Journal Of Haematology ◽

10.1111/j.1600-0609.2004.00262.x ◽

2004 ◽

Vol 73 (2) ◽

pp. 134-138 ◽

Cited By ~ 12

Author(s):

Yossi Cohen ◽

Gail Amir ◽

Ginette Schibi ◽

Ninette Amariglio ◽

Aaron Polliack

Keyword(s):

B Cell ◽

Wegener’S Granulomatosis ◽

Clinical Presentation ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Wegener's Granulomatosis ◽

Large B Cell Lymphoma ◽

Large B Cell

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Anaplastic lymphoma kinase-positive diffuse large B cell lymphoma: immunohistochemical and FISH analysis of a rare tumor with unusual clinical presentation

Journal of Hematopathology ◽

10.1007/s12308-013-0183-y ◽

2013 ◽

Vol 6 (4) ◽

pp. 231-235

Author(s):

Μ. G. Ioannou ◽

E. Kouvaras ◽

P. Panagiotidis ◽

R. Papamichali ◽

C. Papacharalambous ◽

...

Keyword(s):

B Cell ◽

Anaplastic Lymphoma Kinase ◽

Clinical Presentation ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Fish Analysis ◽

Rare Tumor ◽

Anaplastic Lymphoma ◽

Large B Cell Lymphoma ◽

Large B Cell

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Bone Marrow-Liver-Spleen Type of Large B-Cell Lymphoma Associated with Hemophagocytic Syndrome: A Rare Aggressive Extranodal Lymphoma

Case Reports in Hematology ◽

10.1155/2017/8496978 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Kirill A. Lyapichev ◽

Jennifer R. Chapman ◽

Oleksii Iakymenko ◽

Offiong F. Ikpatt ◽

Uygar Teomete ◽

...

Keyword(s):

Bone Marrow ◽

B Cell ◽

Clinical Presentation ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Aggressive Lymphoma ◽

Lymphoma Cells ◽

Large B Cell Lymphoma ◽

Pathologic Features ◽

Large B Cell

Recently, an unusual subtype of large B-cell lymphoma (LBCL) with distinctive clinicopathologic features has been recognized; it is characterized by involvement of bone marrow with or without liver and/or spleen, but no lymph node or other extranodal sites, usually associated with fever, anemia, and hemophagocytic lymphohistiocytosis (HLH). Because of this distinctive clinical presentation, it has been designated “bone marrow-liver-spleen” (BLS) type of LBCL. To date there is only one series of 11 cases of BLS type of LBCL with detailed clinical, pathologic, and cytogenetic data. Herein, we describe a case of BLS type LBCL presenting with associated HLH in a 73-year-old female. The bone marrow core biopsy showed cytologically atypical large lymphoma cells present in a scattered interstitial distribution and hemophagocytosis and infrequent large lymphoma cells were seen in the bone marrow aspirate smears. Circulating lymphoma cells were not seen in the peripheral blood smears. The patient underwent treatment with chemotherapy (R-CHOP) but unfortunately passed away 2 months after initial presentation. BLS type of LBCL is a very rare and clinically aggressive lymphoma whose identification may be delayed by clinicians and hematopathologists due to its unusual clinical presentation and pathologic features.

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