scholarly journals Bilateral Testicular Epidermoid Cysts

2011 ◽  
Vol 1 ◽  
pp. 4 ◽  
Author(s):  
Norman Loberant ◽  
Shweta Bhatt ◽  
Edward Messing ◽  
Vikram S. Dogra
Keyword(s):  
Germ Cell ◽  
Epidermoid Cyst ◽  
Testicular Germ Cell Tumor ◽  
Rare Condition ◽  
Cell Tumor ◽  
Benign Tumors ◽  
Testicular Tumors ◽  
Testicular Germ Cell ◽  
Epidermoid Cysts ◽  
High Index Of Suspicion

Testicular epidermoid cysts are the most common benign tumors of the testes, but account for only 1-2% of all testicular tumors. In a young man presenting with a testicular mass, a high index of suspicion must be maintained for the malignant testicular germ cell tumor, which is 50-times more common than testicular epidermoid cyst. Bilateral testicular epidermoid cysts are a very rare condition, with only a few reports in the literature. It is extremely important in this condition to make a correct pre-operative diagnosis on imaging to enable a testis-sparing surgery.

scholarly journals Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study

2021 ◽  
Vol 27 ◽  
pp. 107602962110247
Author(s):  
Hikmat Abdel-Razeq ◽  
Faris Tamimi ◽  
Rashid Abdel-Razeq ◽  
Samer Salah ◽  
Zaid Omari ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Germ Cell ◽  
Metastatic Disease ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumor ◽  
Tumor Burden ◽  
Testicular Tumors ◽  
Testicular Germ Cell ◽  
Node Positive ◽  
Age Range

Malignancy, including testicular tumors, significantly increases the risk of venous thromboembolism (VTE). In this study, we search for predictors that may help identify subgroups of patients at higher risk of VTE. Patients with confirmed diagnosis of testicular germ cell tumor and proven VTE were identified. Clinical and pathological features possibly associated with VTE were reviewed. A total of 322 patients, median age (range) 31 (18-76) years were identified. Tumors were mostly non-seminoma (n = 194, 60.2%), node-positive (n = 130, 40.4%) and 58 (18.0%) had metastatic disease at diagnosis. Venous thromboembolism were confirmed in 27 (8.4%) patients; however, rates were significantly higher ( P < 0.001) in patients with node-positive (18.5%), metastatic disease (22.4%), and those with high lactate dehydrogenase (LDH) (21.3%). Rates were also significantly higher among those who received multiple lines of chemotherapy (27.5%) compared to those who received one line (13.8%) or none (<1.0%), P < 0.001. Patients with testicular tumors and high tumor burden, including nodal involvement, high LDH or metastatic disease, and those treated with multiple lines of chemotherapy have significantly higher rates of VTE.

Testicular germ cell tumor with pineal metastases

Neurosurgery ◽  
1990 ◽  
pp. 688 ◽  
Author(s):  
B Delahunt ◽  
H H Teoh ◽  
V Balakrishnan ◽  
J N Nacey ◽  
S P Clark
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell

666 A NOVEL RISK STRATIFICATION SYSTEM FOR CHEMOTHERAPY FAILURE IN TESTICULAR GERM CELL TUMOR

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Jessica Lubahn ◽  
Nicholas Cost ◽  
Mehrad Adibi ◽  
Adam Romman ◽  
Ganesh Raj ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Stratification System ◽  
Risk Stratification System

scholarly journals A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility

2011 ◽  
Vol 20 (15) ◽  
pp. 3109-3117 ◽  
Author(s):  
Peter A. Kanetsky ◽  
Nandita Mitra ◽  
Saran Vardhanabhuti ◽  
David J. Vaughn ◽  
Mingyao Li ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Tumor Susceptibility ◽  
Independent Locus

scholarly journals The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1

2015 ◽  
Vol 87 (1) ◽  
pp. 389-404 ◽  
Author(s):  
DANIJELA DRAKULIC ◽  
JELENA MARJANOVIC VICENTIC ◽  
MARIJA SCHWIRTLICH ◽  
JELENA TOSIC ◽  
ALEKSANDAR KRSTIC ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tumor Suppressor ◽  
Cancer Stem Cells ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Teratocarcinoma Cell ◽  
Altered Expression

The altered expression of the SOX2 transcription factor is associated with oncogenic or tumor suppressor functions in human cancers. This factor regulates the migration and invasion of different cancer cells. In this study we investigated the effect of constitutive SOX2 overexpression on the migration and adhesion capacity of embryonal teratocarcinoma NT2/D1 cells derived from a metastasis of a human testicular germ cell tumor. We detected that increased SOX2 expression changed the speed, mode and path of cell migration, but not the adhesion ability of NT2/D1 cells. Additionally, we demonstrated that SOX2 overexpression increased the expression of the tumor suppressor protein p53 and the HDM2 oncogene. Our results contribute to the better understanding of the effect of SOX2 on the behavior of tumor cells originating from a human testicular germ cell tumor. Considering that NT2/D1 cells resemble cancer stem cells in many features, our results could contribute to the elucidation of the role of SOX2 in cancer stem cells behavior and the process of metastasis.

scholarly journals Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor

2018 ◽  
Vol 9 (23) ◽  
pp. 4440-4448 ◽  
Author(s):  
Tatsuro Abe ◽  
Kenichi Kohashi ◽  
Junkichi Takemoto ◽  
Fumio Kinoshita ◽  
Masatoshi Eto ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Antitumor Effect ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Clinicopathological Significance
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