Anterior craniofacial resection for squamous cell carcinoma ethmoid sinus involving anterior skull base

Author(s):  
Saurabh Varshney ◽  
Sumeet Angral ◽  
RajnishKumar Arora ◽  
Manu Malhotra ◽  
AmitKumar Tyagi ◽  
...  
2017 ◽  
Vol 10 (1) ◽  
pp. 339-349
Author(s):  
Takeharu Ono ◽  
Norimitsu Tanaka ◽  
Hirohito Umeno ◽  
Kiyohiko Sakata ◽  
Motohiro Morioka ◽  
...  

We retrospectively analyzed 14 patients with locally advanced squamous cell carcinoma of ethmoid sinus (LASCC-ES) for the feasibility of anterior craniofacial resection (ACFR). Ethmoid cancer treatment comprised alternating chemoradiotherapy (ALCRT; n = 1), concomitant radiotherapy and intra-arterial cisplatin (RADPLAT; n = 4) and ACFR (n = 9). The 3- and 5-year overall survival (OS) rates of patients were 47.6 and 39.6%, respectively. The 3-year local control (LC) rates of chemoradiotherapy (CRT; ALCRT and RADPLAT) (n = 5) and ACFR (n = 9) groups were 0 and 66.7% (p = 0.012), respectively. The 3-year progression-free survival (PFS) rate of the CRT and ACFR groups were 0 and 55.6% (p = 0.018), respectively. The 3-year OS rate of the CRT and ACFR groups were 0 and 76.2% (p = 0.005), respectively. Postoperative pathological examinations confirmed positive margins in 3 (33%) of 9 cases. The 3-year LC and PFS rates of cases (n = 3) with positive surgical margins were significantly poorer than those of cases (n = 6) with negative surgical margins. Although ACFR for LASCC-ES is a feasible treatment, cases with positive surgical margins were more prone to local relapse. Therefore, surgical safety margins should be thoroughly assessed.


Head & Neck ◽  
2014 ◽  
Vol 37 (8) ◽  
pp. 1163-1169 ◽  
Author(s):  
John R. de Almeida ◽  
Shirley Y. Su ◽  
Maria Koutourousiou ◽  
Francisco Vaz Guimaraes Filho ◽  
Juan C. Fernandez Miranda ◽  
...  

2015 ◽  
Vol 42 (5) ◽  
pp. 377-381 ◽  
Author(s):  
Akihiro Homma ◽  
Yuji Nakamaru ◽  
Tomohiro Sakashita ◽  
Rikiya Onimaru ◽  
Shunsuke Terasaka ◽  
...  

Cureus ◽  
2019 ◽  
Author(s):  
Samer G Zammar ◽  
Max Hennessy ◽  
Joshua Warrick ◽  
Neerav Goyal ◽  
Brad E Zacharia

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