Objectives: The number of human studies on the association and clinical signicance of alterations in
IL-6, sP-Selectin, TNF-α, BNP-32, or procalcitonin (PCT) in lung cancer is small. We aimed to investigate
the alterations of proinammatory cytokines and acute-phase reactants in blood and pleural uid and determine their clinical
diagnostic or prognostic signicances regarding tumor type, stage, size, standardized uptake value (SUV), and
lymphovascular invasion (LVI). Methods: Levels of IL-6, TNF-α, BNP-32, PCT, and sP-selectin were evaluated in blood samples
st th st th th obtained preoperatively and postoperatively on 1 , 6 hours and 1 , 4 , and seven days. They also were evaluated in pleural
st uid samples obtained postoperatively on 1 hour, and rst and fourth days. These results were analyzed according to the cell
type, size, stage, SUV, and LVI of lung cancer. IL-6 values in plasma and pleural uid had Results: various signicant
relationships and correlations with histological type, diameter, SUV, stage, and LVI of the tumor. TNF-α values in plasma or
pleural uid had signicant relationships with LVI only. PCT values in plasma or pleural uid had signicant relationships with
the tumor's diameter, SUV, and LVI. BNP-32 values in plasma or pleural uid had signicant relationships with histological type
and SUV of the tumor. sP-Selectin values in plasma or pleural uid had signicant relationships with the stage and SUV of the
tumor. We determined various signicant associations and correlations of proinammatory cytokines wi Conclusions: th
histological type, size, stage, LVI, and SUV of lung cancer. Studies on this subject would serve to develop diagnostic and
prognostic methods in lung cancers.
Intraoperative transcranial facial motor evoked potential monitoring in surgery of cerebellopontine angle tumors predicts early and late postoperative facial nerve function
