Acute liver failure due to hypoxic hepatitis successfully treated with plasma exchange

2022 ◽  
Vol 2 (1) ◽  
pp. 30
Author(s):  
Allwin James ◽  
Alagammai Palaniappan ◽  
Ramesh Ardhanari ◽  
Sandheep Janardhanan
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Hypoxic Hepatitis

scholarly journals A Case of Exertional Heat Stroke Complicated by Hypoxic Hepatitis

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Bertram K. Woitok ◽  
Shawki Bahmad ◽  
Gregor Lindner
Keyword(s):  
Supportive Care ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Multiorgan Failure ◽  
Heat Stroke ◽  
Exertional Heat Stroke ◽  
Hypoxic Hepatitis ◽  
Threatening Condition ◽  
Life Threatening ◽  
Delayed Referral

Background.Exertional heat stroke is a life-threatening condition often complicated by multiorgan failure. We hereby present a case of a 25-year-old male presenting with syncope after a 10  km run in 28°C outside temperature who developed acute liver failure. Case Presentation. Initial temperature was found to be 41.1°C, and cooling measures were rapidly applied. He suffered from acute renal failure and rhabdomyolysis and proceeded to acute liver failure (ASAT 6100 U/l and ALAT 6561 U/l) due to hypoxic hepatitis on day 3. He did not meet criteria for emergency liver transplantation and recovered on supportive care. Conclusions. Acute liver failure due to heat stroke is a life-threatening condition with often delayed onset, which nevertheless resolves on supportive care in the majority of cases; thus, a delayed referral to transplant seems to be reasonable.

scholarly journals Reply to: “Acute liver failure due to immune-mediated hepatitis successfully managed with plasma exchange: New settings call for new treatment strategies?”

2019 ◽  
Vol 70 (3) ◽  
pp. 566-567 ◽  
Author(s):  
Eleonora De Martin ◽  
Jean-Marie Michot ◽  
Barbara Papouin ◽  
Stephane Champiat ◽  
Olivier Lambotte ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Treatment Strategies ◽  
Immune Mediated ◽  
New Treatment

scholarly journals Therapeutic plasma exchange in children with acute liver failure (ALF): is it time for incorporation into the ALF armamentarium?

2021 ◽  
Author(s):  
Emma C. Alexander ◽  
Akash Deep
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Controlled Trial ◽  
High Volume ◽  
Systemic Circulation ◽  
Liver Support ◽  
Extracorporeal Liver Support ◽  
Randomised Controlled ◽  
Liver Assist Devices

AbstractPaediatric acute liver failure (PALF) is a rare but devastating condition with high mortality. An exaggerated inflammatory response is now recognised as pivotal in the pathogenesis and prognosis of ALF, with cytokine spill from the liver to systemic circulation implicated in development of multi-organ failure associated with ALF. With advances in medical management, especially critical care, there is an increasing trend towards spontaneous liver regeneration, averting the need for emergency liver transplantation or providing stability to the patient awaiting a graft. Hence, research is ongoing for therapies, including extracorporeal liver support devices, that can bridge patients to transplant or spontaneous liver recovery. Considering the immune-related pathogenesis and inflammatory phenotype of ALF, plasma exchange serves as an ideal liver assist device as it performs both the excretory and synthetic functions of the liver and, in addition, works as an immunomodulatory therapy by suppressing the early innate immune response in ALF. After a recent randomised controlled trial in adults demonstrated a beneficial effect of high-volume plasma exchange on clinical outcomes, this therapy was incorporated in European Association for the Study of Liver (EASL) recommendations for managing adult patients with ALF, but no guidelines exist for PALF. In this review, we discuss rationale, timing, practicalities, and existing evidence regarding the use of plasma exchange as an immunomodulatory treatment in PALF. We discuss controversies in delivery of this therapy as an extracorporeal device, and practicalities of use of plasma exchange as a ‘hybrid’ therapy alongside other extracorporeal liver assist devices, before finally reviewing outstanding research questions for the future.

High volume plasma exchange in acute liver failure: Dampening the inflammatory cascade?

2016 ◽  
Vol 64 (1) ◽  
pp. 10-12 ◽  
Author(s):  
Constantine J. Karvellas ◽  
R. Todd Stravitz
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
High Volume ◽  
Inflammatory Cascade

scholarly journals Therapeutic plasma exchange in acute liver failure

2019 ◽  
Vol 34 (5) ◽  
pp. 589-597 ◽  
Author(s):  
Klaus Stahl ◽  
Johannes Hadem ◽  
Andrea Schneider ◽  
Michael P. Manns ◽  
Olaf Wiesner ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Therapeutic Plasma Exchange

Continuous Veno-Venous Hemodiafiltration and Plasma Exchange in Infantile Acute Liver Failure

2015 ◽  
Vol 16 (8) ◽  
pp. e268-e274 ◽  
Author(s):  
Kentaro Ide ◽  
Takashi Muguruma ◽  
Mafumi Shinohara ◽  
Chiaki Toida ◽  
Yuki Enomoto ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange

High-volume plasma exchange in a patient with acute liver failure due to non-exertional heat stroke in a sauna

2014 ◽  
Vol 29 (5) ◽  
pp. 281-283 ◽  
Author(s):  
Kuan-Jung Chen ◽  
Tso-Hsiao Chen ◽  
Yuh-Mou Sue ◽  
Tzay-Jinn Chen ◽  
Chung-Yi Cheng
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Heat Stroke ◽  
High Volume ◽  
Exertional Heat Stroke

Selective Plasma Exchange With Dialysis in Patients With Acute Liver Failure

2012 ◽  
Vol 16 (5) ◽  
pp. 467-471 ◽  
Author(s):  
Hajime Nakae ◽  
Toshiko Igarashi ◽  
Kimitaka Tajimi
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange

scholarly journals Comparison of Molecular Adsorbents Recirculating System (MARS) dialysis with combined plasma exchange and haemodialysis in children with acute liver failure

2011 ◽  
Vol 26 (11) ◽  
pp. 3633-3639 ◽  
Author(s):  
B. Schaefer ◽  
F. Schaefer ◽  
G. Engelmann ◽  
J. Meyburg ◽  
K. H. Heckert ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange
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