scholarly journals A Case of Exertional Heat Stroke Complicated by Hypoxic Hepatitis

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Bertram K. Woitok ◽  
Shawki Bahmad ◽  
Gregor Lindner
Keyword(s):  
Supportive Care ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Multiorgan Failure ◽  
Heat Stroke ◽  
Exertional Heat Stroke ◽  
Hypoxic Hepatitis ◽  
Threatening Condition ◽  
Life Threatening ◽  
Delayed Referral

Background.Exertional heat stroke is a life-threatening condition often complicated by multiorgan failure. We hereby present a case of a 25-year-old male presenting with syncope after a 10  km run in 28°C outside temperature who developed acute liver failure. Case Presentation. Initial temperature was found to be 41.1°C, and cooling measures were rapidly applied. He suffered from acute renal failure and rhabdomyolysis and proceeded to acute liver failure (ASAT 6100 U/l and ALAT 6561 U/l) due to hypoxic hepatitis on day 3. He did not meet criteria for emergency liver transplantation and recovered on supportive care. Conclusions. Acute liver failure due to heat stroke is a life-threatening condition with often delayed onset, which nevertheless resolves on supportive care in the majority of cases; thus, a delayed referral to transplant seems to be reasonable.

scholarly journals Exertional heat stroke associated with acute liver failure in a young refugee. Implications in the era of social-economic crisis

2019 ◽  
Vol 28 (3) ◽  
pp. 364-364
Author(s):  
Dimitrios S. Politis ◽  
Gerasimos Baltagiannis ◽  
Nikolaos Tzampouras ◽  
George N Kalambokis ◽  
Vasileios Koulouras ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Economic Crisis ◽  
Social Economic ◽  
Heat Stroke ◽  
Exertional Heat Stroke

.

scholarly journals The Fire from Within: Multiorgan Failure with Bimodal Rhabdomyolysis from Exertional Heat Stroke

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Onion Gerald V. Ubaldo ◽  
Khia Quiwa ◽  
Rohana Elise Rollan ◽  
Edhel Tripon ◽  
Elizabeth Sebastian
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Liver Transplant ◽  
Core Body Temperature ◽  
Multiorgan Failure ◽  
Heat Stroke ◽  
Exertional Heat Stroke ◽  
Liver Support ◽  
Central Nervous System Dysfunction ◽  
Extracorporeal Liver Support

Heat stroke (HS) is a condition characterized by a rise in core body temperature and central nervous system dysfunction. It is divided into two types: classical and exertional. Exertional heat stroke (EHS) is accompanied by organ failure. Liver injury, presenting only with a rise in liver enzymes, is common but in rare conditions, acute liver failure (ALF) may ensue, leading to a potentially lethal condition. Most cases of EHS-induced ALF are managed conservatively. However, liver transplantation is considered for cases refractory to supportive treatment. Identifying patients eligible for liver transplantation in the context of an EHS-induced ALF becomes a medical dilemma since the conventional prognostic criterion may be difficult to apply, and there is paucity of literature about these specific sets of individuals. Recently, extracorporeal liver support has been gaining popularity for patients with liver failure as a bridge to liver transplant. In this case report, we present a young Filipino athlete with symptoms and clinical course consistent with EHS that developed multiorgan failure, initially considered a candidate for liver transplant and total plasma exchange, but clinically improved with supportive management alone. This patient was also found to have bimodal rhabdomyolysis during the course of his hospital stay as manifested by the bimodal rise in his creatine kinase enzymes.

Acute Liver Failure

2017 ◽  
Author(s):  
Cynthia Wang ◽  
Michelle Y. Braunfeld
Keyword(s):  
Supportive Care ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Intraoperative Monitoring ◽  
Multiorgan Failure ◽  
Anesthetic Management ◽  
Specific Treatment ◽  
Patient Specific ◽  
Drug Induced

Acute liver failure produces widespread physiologic derangements including encephalopathy, coagulopathy, peripheral vasodilation, a systemic inflammatory response, and multiorgan failure. Morbidity is significant, and mortality is 50%. The classification of liver failure and the various etiologies, including viral hepatitis, drug-induced, toxins, and autoimmunity are reviewed here. The multisystem effects of acute liver failure influence all aspects of perioperative care and adequate supportive care during this time is crucial to providing the best possible outcome for the patient. Specific treatment objectives and recommendations are discussed, and the anesthetic management with regard to drug choices, hemodynamic goals, and intraoperative monitoring is reviewed.

High-volume plasma exchange in a patient with acute liver failure due to non-exertional heat stroke in a sauna

2014 ◽  
Vol 29 (5) ◽  
pp. 281-283 ◽  
Author(s):  
Kuan-Jung Chen ◽  
Tso-Hsiao Chen ◽  
Yuh-Mou Sue ◽  
Tzay-Jinn Chen ◽  
Chung-Yi Cheng
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Heat Stroke ◽  
High Volume ◽  
Exertional Heat Stroke

Acute Liver Failure: A Rare Primary Sequela of Exertional Heat Stroke

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S1277
Author(s):  
Lindsay Clarke ◽  
Daniel Szvarca ◽  
Danielle Davison ◽  
Bedoor Alabbas ◽  
Marie Borum
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Heat Stroke ◽  
Exertional Heat Stroke

Exertional Heat Stroke in a Young Athlete Resulting in Acute Liver Failure

2016 ◽  
Vol 63 (4) ◽  
pp. e75-e76 ◽  
Author(s):  
Jacob A. Kurowski ◽  
Henry C. Lin ◽  
Saeed Mohammad ◽  
Steven Krug ◽  
Estella M. Alonso
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Heat Stroke ◽  
Young Athlete ◽  
Exertional Heat Stroke

scholarly journals Plasma Exchange as a Rescue Therapy for Acute Liver Failure

2021 ◽  
Author(s):  
Nupur B Patel ◽  
Anand Sharma ◽  
Itish Patnaik ◽  
Ashok Kumar
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Resource Constraints ◽  
Rescue Therapy ◽  
Therapeutic Option ◽  
Liver Function Tests ◽  
Threatening Condition ◽  
Life Threatening

Acute Liver Failure (ALF) is a life-threatening condition and often necessitates Liver Transplantation (LT). However, LT is not available to most patients in developing countries due to resource constraints. Here, authors presents a case of 30-year-old female with ALF and fulfilled the criteria for LT. The aetiology of ALF could not be diagnosed in her. Due to the lack of LT facilities, she was offered plasma exchange as a therapeutic option, which resulted in improvement in sensorium and Liver Function Tests (LFT) {bilirubin, International Normalised Ratio (INR), Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT)} over a period of two weeks. She was discharged and was doing well during follow-up. Plasma exchange is a less studied but potential treatment option for ALF when LT is not feasible.

Acute Liver Failure Complicating Exertional Heat Stroke

2015 ◽  
Vol 14 (1) ◽  
pp. 49-50 ◽  
Author(s):  
Cécile Salathé ◽  
Cyril Pellaton ◽  
Pierre-Nicolas Carron ◽  
Marcos Coronado ◽  
Lucas Liaudet
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Heat Stroke ◽  
Exertional Heat Stroke

scholarly journals Fatal Heat Stroke in a Schizophrenic Patient

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
María Jesús Gómez Ramos ◽  
Francisco Miguel González Valverde ◽  
Carmen Sánchez Álvarez ◽  
Lisa Ortin Katnich ◽  
Francisco Pastor Quirante
Keyword(s):  
Supportive Care ◽  
Multiorgan Failure ◽  
Heat Stroke ◽  
Best Supportive Care ◽  
Histological Evaluation ◽  
Life Threatening ◽  
History Of ◽  
Body Cooling ◽  
Salt And Water Balance ◽  
Obesity Hypertension

Objective. The case of a patient who developed a fatal post-exertional heat stroke is reported.Case Report. A 20-year-old man with a history of morbid obesity, hypertension, and schizophrenia was admitted to our intensive care unit because of multiorgan failure due to severe heat stroke. He had been working under the sun. Treatment included aggressive body cooling but, in spite of the best supportive care, the patient succumbed in a few hours. We concluded that the adverse event was possibly associated with his obesity and the use of antipsychotics. Histological evaluation revealed lesions consistent with severe hyperthermia and shock.Conclusions. Heat stroke is an uncommon clinical entity characterized by systemic heat and loss of the body's normal mechanisms for dealing with heat stress, such as sweating and temperature control. When heat stroke is diagnosed early and supportive care begins promptly the prognosis is optimal but it becomes a life-threatening disease when treatment is delayed. Lack of physical acclimatization and the use of certain medications that interfere with salt and water balance can impair thermoregulation under conditions of high environmental temperature. Health professionals must be adequately prepared to prevent, recognise, and treat them urgently.

scholarly journals Case Report: Pediatric Recurrent Acute Liver Failure Caused by Neuroblastoma Amplified Sequence (NBAS) Gene Mutations

2021 ◽  
Vol 8 ◽  
Author(s):  
Bingxin Jiang ◽  
Fangfei Xiao ◽  
Xiaolu Li ◽  
Yongmei Xiao ◽  
Yizhong Wang ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Gene Mutations ◽  
Kidney Injury ◽  
Compound Heterozygote ◽  
Healthy Children ◽  
Whole Exome ◽  
Threatening Condition ◽  
Chinese Girl ◽  
Life Threatening

Acute liver failure (ALF) in childhood is a rapidly progressive, potentially life-threatening condition that occurs in previously healthy children of all ages. However, the etiology of ~50% of cases with pediatric ALF remains unknown. We herein report a 4-year-old Chinese girl with recurrent ALF (RALF) due to a mutation in the neuroblastoma amplified sequence (NBAS) gene. The patient had suffered from multiple episodes of fever-related ALF since early childhood. She had also suffered from acute kidney injury, hypertension, mild pulmonary hypertension, pleural effusion, and hypothyroidism. A novel compound heterozygote mutation, c.3596G> A (p.C1199Y)/ex.9del (p.216-248del), in the NBAS gene was identified by whole-exome sequencing (WES). The missense mutation c.3596G> A (p. C1199Y) was inherited from her father, and ex.9del (p.216-248del) was inherited from her mother. The patient was managed with intensive treatments, such as renal replacement therapy (CRRT), intravenous antibiotics, and glucose infusion, and was discharged after full recovery. We identified a novel compound heterozygote mutation in the NBAS gene that caused fever-related RALF in a Chinese child, which further expands the mutational spectrum of NBAS.

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