Prevalence of oral mucosal lesions, dental caries, and periodontal disease among patients with systemic lupus erythematosus in a teaching hospital in Chennai, Tamil Nadu

Systemic Lupus Erythematosus (SLE) is an autoimmune rheumatic disease, principally affecting women during child bearing years and is characterized by the presence of auto antibodies against a variety of auto antigens such as double-stranded DNA, intracellular ribonuclear proteins and membrane phospholipids. The presentation of lupus erythematosus ranges from a skin rash unaccompanied by extracutaneous stigmata to a rapidly progressive lethal multiorgan disease. A wide spectrum of oral mucosal lesions is found in the cutaneous and systemic forms of lupus erythematosus. We report a 11-year-old female child with classical features of Systemic Lupus Erythematosus associated with oral mucosal lesions.

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Systemic lupus erythematosus presenting with oral mucosal lesions: easily missed?

British Journal of Dermatology ◽

10.1046/j.1365-2133.2001.04236.x ◽

2001 ◽

Vol 144 (6) ◽

pp. 1219-1223 ◽

Cited By ~ 30

Author(s):

C.H. Orteu ◽

J.A.G. Buchanan ◽

I. Hutchison ◽

I.M. Leigh ◽

R.H. Bull

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Oral Mucosal Lesions ◽

Mucosal Lesions

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The prevalence of oral mucosal lesions and related factors in systemic lupus erythematosus patients

Arthritis Research & Therapy ◽

10.1186/s13075-021-02614-8 ◽

2021 ◽

Vol 23 (1) ◽

Author(s):

Mayssoun Kudsi ◽

Louei Darjazini Nahas ◽

Rama Alsawah ◽

Ahmad Hamsho ◽

Abdullah Omar

Keyword(s):

Systemic Lupus Erythematosus ◽

Clinical Examination ◽

Lupus Erythematosus ◽

Oral Lesions ◽

Systemic Lupus ◽

Related Factors ◽

Wide Range ◽

Significant Difference ◽

Oral Mucosal Lesions ◽

Mucosal Lesions

Abstract Background Systemic lupus erythematosus (SLE) is a chronic inflammatory multi systematic disease of unknown aetiology. SLE has a wide range of symptoms. The most common symptoms are joint pain, skin rash and fever. Oral lesions in SLE manifest in a variety of forms, such as oral mucosal ulceration, mouth burns, xerostomia and salivary gland diseases, temporomandibular joint disease, periodontal disease, dysgeusia, white lesions, oedema, bleeding and petechiae. Objective This study was conducted to evaluate the prevalence of oral mucosal lesions and their related factors in patients with SLE, giving the lack of comprehensive statistical data in Syria and the differences between reported prevalence. Patients and methods A cross-sectional study was performed in the Al-Mouassat University Hospital in Damascus. Patients were evaluated appropriating observation, clinical examination, completing questionnaires, studying patient’s medical records and paraclinical laboratory tests if required. Four types of oral lesions were evaluated: ulcer, erythema, white plaque and spots. The diagnosis of these lesions was made according to observation and clinical examination, and the location of each lesion was also recorded. Data were analysed using SPSS version 16.0. Result In this study, 42 (70% %) out of 60 patients (38 women and 4 men) had oral lesions, while 18 (30%) had none. The most common areas for the lesions were the buccal mucosa (26.1%) and the lips (14.2%). Of the 42 patients with oral lesions, 12 (27.6%) showed ulcers. There was a significant relationship between the following factors and oral lesions: oral hygiene status, the duration of the disease involvement, frequency of pregnancies, the amount of daily use of corticosteroids without significant difference between dosage groups, and medications used for SLE treatment other than corticosteroids (p < 0.008) without mentioned names or dosages. Conversely, age, sex, cigarette smoking and medications other than those used for SLE treatment were not significantly related to the presence of oral lesions (p value was greater than 0.05 in all subjects).

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Clinical characteristics of oral mucosal lesions in patients with systemic lupus erythematosus and their association with clinical and laboratory parameters

GSC Advanced Research and Reviews ◽

10.30574/gscarr.2021.6.2.0013 ◽

2021 ◽

Vol 6 (2) ◽

pp. 001-012

Author(s):

Lilly Esquivel-Pedraza ◽

Laura Fernández-Cuevas ◽

Alba Cicero-Casarrubias ◽

Sergio Ponce de León-Rosales ◽

Mónica Fernández-Sánchez ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Laboratory Data ◽

Oral Manifestations ◽

Systemic Lupus ◽

Cross Sectional ◽

Laboratory Parameters ◽

Oral Mucosal Lesions ◽

Dna Antibodies ◽

Mucosal Lesions

Introduction. Systemic lupus erythematosus (SLE) is an autoimmune disease that includes a broad spectrum of mucocutaneous manifestations. Objectives. To characterize the clinical spectrum of oral mucosal lesions in patients with SLE and to analize their association with clinical and laboratory parameters. Methods. We performed a cross-sectional study with systematic oral evaluations in SLE adult patients. Systemic and cutaneous lupus activities were recorded. We collected epidemiologic, clinical, and laboratory data. Statistical analysis included the kappa coefficient, X2 test, Fisher’s exact test and Mann-Whitney U-test, adjusting for multiple comparisons according to Bonferroni’s method. Results. A total of 181 patients (92.8% females) were included, with a median age of 37 (range 16-76) years. Cutaneous, systemic, and oral manifestations of lupus erythematosus (LE) activity were found in 31.5%, 23.8% and 18.8% of patients, respectively. Higher titres of anti-double-stranded (ds) DNA antibodies were detected in patients with LE-related oral lesions (LEOL) when compared to those without LEOL [356 (82-1083) UI vs 45 (0-417) UI; p=0.02). LEOL did not correlate to cutaneous (k=0.380) nor systemic (k=0.228) LE-activity (p<0.01). Conclusions. Oral manifestations related to SLE were significantly associated to anti double-ds DNA antibodies. LEOL were independent of cutaneous and systemic activity.

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