Raisins preserve thyroid gland function and structure in an animal model of hypercholesterolemia

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Nasra Ayuob ◽  
SoadAli Shaker ◽  
Abdulaziz Bakhshwin ◽  
Samar Alsaggaf ◽  
Ghada Helal ◽  
...  
2000 ◽  
Vol 83 (5) ◽  
pp. 3101-3112 ◽  
Author(s):  
Marlies Knipper ◽  
Christoph Zinn ◽  
Hannes Maier ◽  
Mark Praetorius ◽  
Karin Rohbock ◽  
...  

Both a genetic or acquired neonatal thyroid hormone (TH) deficiency may result in a profound mental disability that is often accompanied by deafness. The existence of various TH-sensitive periods during inner ear development and general success of delayed, corrective TH treatment was investigated by treating pregnant and lactating rats with the goitrogen methimazole (MMI). We observed that for the establishment of normal hearing ability, maternal TH, before fetal thyroid gland function on estrus days 17–18, is obviously not required. Within a crucial time between the onset of fetal thyroid gland function and the onset of hearing at postnatal day 12 ( P12), any postponement in the rise of TH-plasma levels, as can be brought about by treating lactating mothers with MMI, leads to permanent hearing defects of the adult offspring. The severity of hearing defects that were measured in 3- to 9-mo-old offspring could be increased with each additional day of TH deficiency during this critical period. Unexpectedly, the active cochlear process, assayed by distortion product otoacoustic emissions (DPOAE) measurements, and speed of auditory brain stem responses, which both until now were not thought to be controlled by TH, proved to be TH-dependent processes that were damaged by a delay of TH supply within this critical time. In contrast, no significant differences in the gross morphology and innervation of the organ of Corti or myelin gene expression in the auditory system, detected as myelin basic protein (MBP) and proteolipid protein (PLP) mRNA using Northern blot approach, were observed when TH supply was delayed for few days. These classical TH-dependent processes, however, were damaged when TH supply was delayed for several weeks. These surprising results may suggest the existence of different TH-dependent processes in the auditory system: those that respond to corrective TH supply (e.g., innervation and morphogenesis of the organ of Corti) and those that do not, but require T3 activity during a very tight time window (e.g., active cochlear process, central processes).


2011 ◽  
Vol 24 (2) ◽  
pp. 377-386 ◽  
Author(s):  
A.V. Sakellaropoulou ◽  
M.N. Hatzistilianou ◽  
M.N. Emporiadou ◽  
V.TH. Aivazis ◽  
I. Rousso ◽  
...  

1963 ◽  
Vol 18 (1) ◽  
pp. 73-76 ◽  
Author(s):  
H. D. Johnson ◽  
H. H. Kibler

A significant depression of the thyroxin I131 disappearance rate was observed in lactating Holstein cows at 80 F, 80% relative humidity (RH); 85 F, 50% RH; 85 F, 70% RH; 90 F, 40% RH; 90 F, 50% RH; and 95 F, 20% RH. Differences from values at 65 F were not significant at 80 F, 30% RH; 80 F, 50% RH; 90 F, 20% RH; and 90 F, 25% RH. At 85 F and 90 F temperatures the effect of high humidity in depressing thyroxin I131 disappearance rate was obvious. Depression of hormone and feed intake at the higher humid temperatures suggests that the depression of thyroid gland function may be related to alteration in hormonal utilization in the peripheral tissues or to a more direct temperature effect (probably neural) on both thyroid gland secretion and appetite center. Thyroxin I131 disappearance rates, feed intake and body temperatures are expressed graphically relative to a temperature humidity index (THI) (U. S. Weather Bureau). The data show some decline above a THI of 71 and a marked decline above 75. Submitted on January 26, 1962


1988 ◽  
Vol 30 (1) ◽  
pp. 94-95 ◽  
Author(s):  
Stefano Tumini ◽  
Francesco Chiarelli ◽  
Alberto Verrotti ◽  
Guido Morgese

2003 ◽  
Vol 35 (6) ◽  
pp. 2222-2223 ◽  
Author(s):  
U Lebkowska ◽  
J Malyszko ◽  
W.J Lebkowski ◽  
J Walecki ◽  
M Mysliwiec

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