Histomorphological spectrum of incidentally detected fallopian tube lesions in patients operated for various clinical conditions and detection of precursor lesion by applying sectioning and extensively examining the fimbriated end sampling protocol

2021 ◽  
Vol 5 (3) ◽  
pp. 85
Author(s):  
Ipsita Dhal ◽  
Neha Singh ◽  
Aneesha Mohanpuria ◽  
Swati Saxena
Keyword(s):  
Fallopian Tube ◽  
Precursor Lesion ◽  
Sampling Protocol ◽  
Clinical Conditions

scholarly journals A multi‐step model of pelvic serous carcinogenesis that originates in the distal fallopian tube from a novel precursor lesion.

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Yonghee Lee ◽  
Alexander Miron ◽  
Ronnie Drapkin ◽  
David W Kindelberger ◽  
Elke Jarboe ◽  
...  
Keyword(s):  
Fallopian Tube ◽  
Precursor Lesion ◽  
Step Model

scholarly journals Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma: Do They Share a Common “Precursor” Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Mamatha Chivukula ◽  
Leo A. Niemeier ◽  
Robert Edwards ◽  
Marina Nikiforova ◽  
Geetha Mantha ◽  
...  
Keyword(s):  
Fallopian Tube ◽  
Tumor Suppressor Genes ◽  
Immunohistochemical Analysis ◽  
Precursor Lesion ◽  
Peritoneal Surface ◽  
Common Precursor ◽  
Intraepithelial Carcinoma ◽  
Polymorphic Microsatellite ◽  
Invasive Carcinomas

As the role of distal fallopian tube as organ of serous carcinogenesis is emerging, additional literature on the role of tubal intraepithelial carcinoma (TIC) as a precursor lesion in a subset of primary peritoneal serous carcinomas (PPSC is emerging as well. TIC although fallopian tube in origin can be genetically related to ovarian/peritoneal carcinomas. The role of PAX2 in primary fallopian tube carcinomas (PFTC)/PPSC is yet to be defined. The aim of our study was to understand if the biologic properties of tumors arising in the distal fallopian tube that remain as PFTC are different when they seed on to the peritoneal surface (PPSC). A panel of 6 polymorphic microsatellite markers corresponding to p53, PAX2, and WT1 tumor suppressor genes were studied. Invasive carcinomas as well as TIC arising in the distal fallopian tube when remain as PFTC appears to exhibit different LOH patterns in comparison to PPSC. PAX 2 LOH patterns might represent a “hidden PAX 2 signature” analogous to p53 signatures. PAX 2 might be an emerging marker for detection of early serous carcinomas particularly in BRCA + women.

Der Einfluß der Inaktivitätsosteoporose auf die szintigraphische Darstellung knöcherner Verletzungen im Bereich des Handgelenks

1989 ◽  
Vol 28 (04) ◽  
pp. 124-128 ◽  
Author(s):  
J. Spitz ◽  
N. Clemenz ◽  
K. Tittel ◽  
H. Weigand
Keyword(s):  
Bone Scintigraphy ◽  
Plaster Cast ◽  
Scaphoid Bone ◽  
X Ray ◽  
The Third ◽  
High Level ◽  
Clinical Conditions ◽  
Rate Of Accumulation

In addition to its established oncological indications the sensitivity of bone scintigraphy is of steadily increasing significance in traumatology. Inactivity- induced osteoporosis plays a major role during the immobilization period in the plaster cast. In the region of the joints remodelling intensity may reach such a high level that the non-injured bone shows a higher rate of accumulation than the fracture. This process already begins between the third and fourth week of immobilization. The highest uptake is found after fracture of the scaphoid bone at the end of twelve weeks of immobilization. Control scintigraphies at intervals of several days are indicated to differentiate between various clinical conditions (pseudoarthrosis, activated osteoarthrosis, algodystrophy in case of doubtful x-ray results).

PCR-RFLP Detection od PAI-2 Gene Variants: Prevelence in Ethnic Groups and Disease Relationship in patients Undergoing corony Angiography

1997 ◽  
Vol 77 (05) ◽  
pp. 0955-0958 ◽  
Author(s):  
Carole A Foy ◽  
Peter J Grant
Keyword(s):  
Gene Variants ◽  
Genotype Distribution ◽  
Pima Indians ◽  
Significant Difference ◽  
Pcr Rflp ◽  
History Of ◽  
Caucasian Patients ◽  
Clinical Conditions ◽  
Rflp Assay ◽  
Coronary Atheroma

SummaryPAI-2 is a fibrinolytic inhibitor produced predominantly by monocytes. Most PAI-2 is intracellular making study in clinical conditions difficult. Abnormalities in production may be associated with inflammation and fibrinolysis at sites of tissue damage such as the atherosclerotic plaque.PAI-2 gene variants have been described: variant A consists of Asn120, Asn404 and Ser413 and variant B consists of Asp120, Lys404 and Cys413. We designed a PCR-RFLP assay using primers spanning the region containing Asn/Lys404 and Ser/Cys413. Variant B contains an Mwol restriction site. We analysed 302 Pima Indians and 286 healthy Caucasian volunteers. To investigate relationships between genotype and vascular disease we analysed 333 Caucasian patients undergoing coronary angiography.Gene variant B was more common in the Pimas than in Caucasians (p <0.0001). There was no significant difference in genotype distribution between the volunteers and patients. In the patients there was no association between genotype and either a history of MI or extent of coronary atheroma.

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