Metabolomics for early detection of drug-induced kidney injury: review of the current status

Bioanalysis ◽  
2009 ◽  
Vol 1 (9) ◽  
pp. 1645-1663 ◽  
Author(s):  
Kurt J Boudonck ◽  
Donald J Rose ◽  
Edward D Karoly ◽  
Douglas P Lee ◽  
Kay A Lawton ◽  
...  
Keyword(s):  
Early Detection ◽  
Kidney Injury ◽  
Current Status ◽  
Drug Induced

Multiplex Optical Urinalysis for Early Detection of Drug-Induced Kidney Injury

2020 ◽  
Vol 92 (8) ◽  
pp. 6166-6172 ◽  
Author(s):  
Penghui Cheng ◽  
Qingqing Miao ◽  
Jiaguo Huang ◽  
Jingchao Li ◽  
Kanyi Pu
Keyword(s):  
Early Detection ◽  
Kidney Injury ◽  
Drug Induced

Deleterious effects of gentamicin and cisplatin on renal function in rats and early detection of drug-induced kidney injury using biomarkers

2013 ◽  
Vol 68 (1) ◽  
pp. e51-e52
Author(s):  
Eric Delpy ◽  
Marine Habault ◽  
Catherine Le Quement ◽  
Christophe Drieu La Rochelle
Keyword(s):  
Renal Function ◽  
Early Detection ◽  
Kidney Injury ◽  
Drug Induced

Urinary Vanin-1 As a Novel Biomarker for Early Detection of Drug-Induced Acute Kidney Injury

2012 ◽  
Vol 341 (3) ◽  
pp. 656-662 ◽  
Author(s):  
Keiko Hosohata ◽  
Hitoshi Ando ◽  
Akio Fujimura
Keyword(s):  
Acute Kidney Injury ◽  
Early Detection ◽  
Kidney Injury ◽  
Drug Induced

Serial Quantification of Urinary Protein Biomarkers to Predict Drug-induced Acute Kidney Injury

2019 ◽  
Vol 20 (8) ◽  
pp. 656-664 ◽  
Author(s):  
Yi Da ◽  
K. Akalya ◽  
Tanusya Murali ◽  
Anantharaman Vathsala ◽  
Chuen-Seng Tan ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cystatin C ◽  
Calcineurin Inhibitors ◽  
Kidney Injury ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Protein Biomarkers ◽  
Drug Induced ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Background: : Drug-induced Acute Kidney Injury (AKI) develops in 10-15% of patients who receive nephrotoxic medications. Urinary biomarkers of renal tubular dysfunction may detect nephrotoxicity early and predict AKI. Methods:: We prospectively studied patients who received aminoglycosides, vancomycin, amphotericin, or calcineurin inhibitors, and collected their serial urine while on therapy. Patients who developed drug-induced AKI (fulfilling KDIGO criteria) were matched with non-AKI controls in a 1:2 ratio. Their urine samples were batch-analyzed at time-intervals leading up to AKI onset; the latter benchmarked against the final day of nephrotoxic therapy in non- AKI controls. Biomarkers examined include clusterin, beta-2-microglobulin, KIM1, MCP1, cystatin-C, trefoil-factor- 3, NGAL, interleukin-18, GST-Pi, calbindin, and osteopontin; biomarkers were normalized with corresponding urine creatinine. Results:: Nine of 84 (11%) patients developed drug-induced AKI. Biomarkers from 7 AKI cases with pre-AKI samples were compared with those from 14 non-AKI controls. Corresponding mean ages were 55(±17) and 52(±16) years; baseline eGFR were 99(±21) and 101(±24) mL/min/1.73m2 (all p=NS). Most biomarker levels peaked before the onset of AKI. Median levels of 5 biomarkers were significantly higher in AKI cases than controls at 1-3 days before AKI onset (all µg/mmol): clusterin [58(8-411) versus 7(3-17)], beta-2-microglobulin [1632(913-3823) versus 253(61-791)], KIM1 [0.16(0.13-0.76) versus 0.07(0.05-0.15)], MCP1 [0.40(0.16-1.90) versus 0.07(0.04-0.17)], and cystatin-C [33(27-2990) versus 11(7-19)], all p<0.05; their AUROC for AKI prediction were >0.80 (confidence intervals >0.50), with average accuracy highest for clusterin (86%), followed by beta-2-microglobulin, cystatin-C, MCP1, and KIM1 (57%) after cross-validation. Conclusion: : Serial surveillance of these biomarkers could improve the lead time for nephrotoxicity detection by days.

scholarly journals Acute interstitial nephritis and drug-induced systemic lupus erythematosus due to chlorthalidone and amiodarone: A case report

2020 ◽  
Vol 8 ◽  
pp. 2050313X2091002 ◽  
Author(s):  
Umut Selamet ◽  
Ramy M Hanna ◽  
Anthony Sisk ◽  
Lama Abdelnour ◽  
Lena Ghobry ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Interstitial Nephritis ◽  
Lupus Erythematosus ◽  
Kidney Biopsy ◽  
Kidney Injury ◽  
Acute Interstitial Nephritis ◽  
Systemic Lupus ◽  
Drug Induced ◽  
Systemic Manifestations

Drug-induced lupus erythematosus has features distinct from primary systemic lupus erythematosus. It can occur with a wide variety of agents that result in the generation of anti-histone or other types of antibodies. Systemic manifestations of drug-induced systemic lupus erythematosus may include renal dysfunction due to circulating immune complexes or due to other immune reactions to the culprit medication(s). Acute interstitial nephritis occurs due to DNA–drug or protein–drug complexes that trigger an allergic immune response. We report a patient who developed acute kidney injury, rash, and drug-induced systemic lupus diagnosed by serologies after starting chlorthalidone and amiodarone. A renal biopsy showed acute interstitial nephritis and not lupus-induced glomerulonephritis. It is important to note that systemic lupus erythematosus and acute interstitial nephritis can occur together, and this report highlights the role of the kidney biopsy in ascertaining the pathological diagnosis and outlining therapy in drug-induced lupus erythematosus.

scholarly journals ePS2.08 Intravenous aminoglycosides in cystic fibrosis patients, early detection of ototoxic drug induced hearing loss; developing a new protocol

2019 ◽  
Vol 18 ◽  
pp. S43-S44
Author(s):  
C. de Kiviet ◽  
M. Van Oirschot ◽  
K. van der Ent
Keyword(s):  
Cystic Fibrosis ◽  
Hearing Loss ◽  
Early Detection ◽  
Drug Induced ◽  
Ototoxic Drug

Electronic alerts for early detection of acute kidney injury: considering their implementation in Australian hospitals

2021 ◽  
Author(s):  
Anna C Bendall ◽  
Sven‐Jean Tan ◽  
Emily J See ◽  
Nigel D Toussaint
Keyword(s):  
Acute Kidney Injury ◽  
Early Detection ◽  
Kidney Injury ◽  
Electronic Alerts
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