scholarly journals p63 in Skin Appendage Development

Cell Cycle ◽  
2007 ◽  
Vol 6 (3) ◽  
pp. 285-290 ◽  
Author(s):  
Marja L. Mikkola
Keyword(s):  
Appendage Development ◽  
Skin Appendage

scholarly journals Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog(Atelerix albiventris)

2020 ◽  
Author(s):  
Hui-Ming Li ◽  
Bi-Ze Yang ◽  
Xiu-Juan Zhang ◽  
Hai-Ying Jiang ◽  
Lin-Miao Li ◽  
...  
Keyword(s):  
Genetic Basis ◽  
Enrichment Analysis ◽  
Differentially Expressed ◽  
Mammal Species ◽  
Appendage Development ◽  
Skin Appendage ◽  
Hair Type ◽  
Spine Development ◽  
Skin Appendages ◽  
Development And Differentiation

Abstract Background: The expression of hair features is an evolutionary adaptation resulting from interactions between many organisms and their environment. Elucidation of the mechanisms that underlie the expression of such traits is a topic in evolutionary biology research; however, the genetic basis of skin appendage development and differentiation remains poorly understood. Therefore, we assessed the de novo transcriptome of the hedgehog ( Atelerix albiventris ) at three developmental stages and compared gene expression profiles between abdomen hair and dorsal spine tissues. Results: We identified 328,576 unigenes in our transcriptome, among which 3,598 were differentially expressed between hair- and spine-type tissues. We identified 3 keratin genes related to hair and spine development through comparative analysis of tissues before and after growth of skin appendages. Dorsal and abdomen skin tissues 5 days after birth were compared and the resulting differentially expressed genes (DEGs) were mainly enriched in keratin filament, intermediate filament, epithelium cell differentiation, and epidermis development based on GO enrichment analysis, and tight junction, p53, and cell cycle signaling pathways based on KEGG enrichment analysis. Expression variations of MBP8, SFN, Wnt10, KRT1 , and KRT2 may be the main factors regulating hair and spine differentiation for the hedgehog. Strikingly, DEGs in hair-type tissues were also significantly enriched in immune-related terms and pathways with hair-type tissues exhibiting more upregulated immune genes than spine-type tissues. Thus, we propose that spine development was an adaptation that provided protection against injuries or stress and reduced hedgehog vulnerability to infection. Conclusion: Our study provided a list of potential genes involved in the regulation of skin appendage development and differentiation in A. albiventris . This is the first transcriptome survey of hair traits for a non-model mammal species, and the candidate genes provided here may provide valuable information for further studies of skin appendages and skin disorder treatments.

Engrailed-1 expression and regulatory role during skin appendage development

1998 ◽  
Vol 16 ◽  
pp. S131
Author(s):  
S. Mohan ◽  
C-X. Tong ◽  
J. Perone ◽  
B. Chubak ◽  
R. Kimmel ◽  
...  
Keyword(s):  
Regulatory Role ◽  
Appendage Development ◽  
Skin Appendage

scholarly journals Developmental transcriptome and genes related to skin appendage differentiation in hedgehog (Atelerix albiventris)

2019 ◽  
Author(s):  
Hui-Ming Li ◽  
Bi-Ze Yang ◽  
Xiu-Juan Zhang ◽  
Lin-Miao Li ◽  
Hai-Ying Jiang ◽  
...  
Keyword(s):  
Genetic Basis ◽  
Developmental Stages ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Development Stage ◽  
Phenotypic Traits ◽  
Skin Development ◽  
Appendage Development ◽  
Skin Appendage ◽  
Development And Differentiation

Abstract Background Hedgehog spines are skin appendages that have evolved as a result of the interaction of their skin with the environment. However, such a differentiation mechanism during skin development leads to a high skin appendage diversity, the origins of which are still not fully understood. Spine-skin and hair-skin offer a natural model for the analysis of the genomic basis for the evolution of epidermal appendage formation. We performed a comparative transcriptomic analysis of hedgehog ( Atelerix albiventris ) at multiple developmental stages, and tried to explore the genetic basis for differentiation and development and the resulting expression of the spine-trait. Results A total 15,158 differentially expressed genes (DEGs) were identified. We determined the gene modules and programs corresponding to the various phenotypic traits at different developmental stages by WGCNA analysis. Objective analysis of gene module expression revealed that HIPPO, TGFB, MAPK and Wnt signaling pathways regulate the activation and cell proliferation and differentiation at the skin-appendage development stage. Further, the key genes encoding keratin, FGF, TEAD, and other proteins regulate molecular localization and the cell cycle for hair development and differentiation. Finally, we found a number of highly expressed immune genes in the skin, suggesting that hedgehog spines, unlike pangolin scales, have evolved independently to protect against predators rather than compensate for low autoimmune immunity. Conclusions The variability of gene expression profiles of hair-type and spine-type at multiple development stages, and key candidate genes and pathways at the molecular level might provide evidence that can help elucidate the genetic basis of skin appendage development and differentiation of hedgehog.

TNF superfamily in skin appendage development

2008 ◽  
Vol 19 (3-4) ◽  
pp. 219-230 ◽  
Author(s):  
Marja L. Mikkola
Keyword(s):  
Appendage Development ◽  
Skin Appendage ◽  
Tnf Superfamily

scholarly journals Conserved Features and Evolutionary Shifts of the EDA Signaling Pathway Involved in Vertebrate Skin Appendage Development

2008 ◽  
Vol 25 (5) ◽  
pp. 912-928 ◽  
Author(s):  
Sophie Pantalacci ◽  
Arnaud Chaumot ◽  
Gérard Benoît ◽  
Alexa Sadier ◽  
Frédéric Delsuc ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Appendage Development ◽  
Skin Appendage

scholarly journals EDA Signaling and Skin Appendage Development

Cell Cycle ◽  
2006 ◽  
Vol 5 (21) ◽  
pp. 2477-2483 ◽  
Author(s):  
Chang-Yi Cui ◽  
David Schlessinger
Keyword(s):  
Appendage Development ◽  
Skin Appendage

scholarly journals Five New CYLD Mutations in Skin Appendage Tumors and Evidence that Aspartic Acid 681 in CYLD Is Essential for Deubiquitinase Activity

2008 ◽  
Vol 128 (3) ◽  
pp. 587-593 ◽  
Author(s):  
Stéphanie Almeida ◽  
Caroline Maillard ◽  
Peter Itin ◽  
Daniel Hohl ◽  
Marcel Huber
Keyword(s):  
Aspartic Acid ◽  
Skin Appendage
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